Anaesthetic management of a patient of Brugada syndrome for an emergency appendicectomy

Abstract

Brugada syndrome is a myocardial transmembrane conduction of sodium abnormality and a common cause of sudden cardiac death. It is characterized by a distinctive electrocardiograph pattern with right bundle branch block and ST segment elevation in precordial leads V1–V3. Many factors during general anesthetic management could precipitate malignant dysrhythmia. We report the anesthetic management of a patient with Brugada syndrome for emergency appendectomy uneventfully.

A Rare Case of Brugada Syndrome of a Female Patient Presented for Labour: Structured Anesthetic and Analgesic Plan for Delivery Management

“…It offers a safe and reliable analgesic option for labour in Brugada syndrome patients. It is not however, suitable for anaesthesia as a solo agent for operative delivery and our plan considered the possibility of the surgical delivery for this patient; Performing spinal anaesthesia and ensuring negligible amounts of bupivacaine in serum have been supported by many case reports [8][9][10]. Although Bupivacaine and propofol are among the drugs to be avoided for Brugada syndrome patients, however It has a "conflicting evidence and/or divergence of opinion about the drug, but the weight of evidence/opinion is in favour of a potentially arrhythmic effect in Brugada syndrome patients" [11].…”

Advances in Rodent Models for Breast Cancer Formation, Progression, and Therapeutic Testing

“…Constitutive knockout of mouse BRCA1 causes recessive mouse embryonic lethality ( 87 ), and therefore, the BRCA1 conditional mutant mouse model was used to overcome this obstacle ( 88 ). Exon 11 is a large central exon of 3426 bp that represents 60% of the coding sequence in BRCA1 ( 89 ). In 1999, Xu established a BRCA1flox11 mutant mouse, which was achieved by deleting only exon 11 of the full-length BRCA1 gene and leaving expression of the short BRCA1 transcript with loxP sites (BRCA1flox11) ( 7 ).…”