Anaesthetic modality and post-surgical oncological outcomes for paediatric tumours: is there a link?

Lee, S.Y.; Acharyya, Sanchalika; Tan, Ashley; Loh, Amos Hong Pheng

doi:10.11622/smedj.2019123

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Alongside, anesthetic agents, such as halothane, isoflurane, and sevoflurane could impair the immune function. Furthermore, opioid analgesics could inhibit cellular and humoral immune function, while morphine may promote angiogenesis [ 37 ].…”

Section: Surgical and Anesthetic Side Effectsmentioning

confidence: 99%

Anesthesia in Children with Neuroblastoma, Perioperative and Operative Management

et al. 2021

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Neuroblastoma (NB) is the most common extracranial, solid, pediatric malignancy and, despite the constant progress of treatment and development of innovative therapies, remains a complex, challenging disease causing major morbidity and mortality in children. There is significant variability in the management of neuroblastoma, partially due to the heterogeneity of the clinical and biological behavior, and partially secondary to the different approaches between treating institutions. Anesthesia takes an integral part in the multidisciplinary care of patients with NB, from diagnosis to surgery and pain control. This paper aims to review and discuss the critical steps of the perioperative and operative management of children undergoing surgery for neuroblastoma. Anesthesia and analgesia largely depend on tumor location, surgical approach, and extension of the surgical dissection. Attention should be paid to the physio-pathological changes on cardiovascular, gastrointestinal, and immune systems induced by the tumor or by chemotherapy. At the time of surgery meticulous patient preparation needs to be carried out to optimize intraoperative monitoring and minimize the risk of complications. The cross-sectional role of anesthesia in cancer care requires effective communication between all members of the multidisciplinary team.

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Section: Surgical and Anesthetic Side Effectsmentioning

confidence: 99%

Anesthesia in Children with Neuroblastoma, Perioperative and Operative Management

et al. 2021

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“…It has been reported that the stress response during the tumour surgery potentially promotes tumour cell survival and spread. 4 Anaesthesia is proposed to be one of the peri-operative factors that affect immunity associated with paediatric tumours. 4 Platelets are usually in a resting state under normal conditions.…”

Section: Introductionmentioning

confidence: 99%

“…4 Anaesthesia is proposed to be one of the peri-operative factors that affect immunity associated with paediatric tumours. 4 Platelets are usually in a resting state under normal conditions. When blood vessels are damaged or platelet activation factors are present in the blood, platelets are activated and contribute to the immune response.…”

Section: Introductionmentioning

confidence: 99%

Different anaesthesia methods affect the development of hepatoblastoma after platelet activation

Fei

Cao

et al. 2021

Int J Experimental Path

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This study aims to compare the influence of different anaesthesia methods on the mechanisms involved in the development of hepatoblastoma (HB). HB rabbit models were constructed and divided into three groups: disoprofol, pentobarbital sodium and HB groups. After anaesthesia, rabbit blood was collected from the tail vein. Haematological analysis (platelets) and an ELISA was used to measure the thrombopoietin (TPO) and 5-hydroxytryptamine (5-HT). Flow cytometry was used to

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Impact of neuraxial analgesia on outcomes following radical cystectomy: A systematic review

Rahman

Cao

Flores

et al. 2021

Urologic Oncology: Seminars and Original Investigations

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Anaesthetic modality and post-surgical oncological outcomes for paediatric tumours: is there a link?

Cited by 5 publications

References 42 publications

Anesthesia in Children with Neuroblastoma, Perioperative and Operative Management

Anesthesia in Children with Neuroblastoma, Perioperative and Operative Management

Different anaesthesia methods affect the development of hepatoblastoma after platelet activation

Impact of neuraxial analgesia on outcomes following radical cystectomy: A systematic review

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