Anal and cervical human papillomavirus infection and risk of anal and cervical epithelial abnormalities in human immunodeficiency virus‐infected women

Ab, Williams; Tm, Darragh; Vranizan, Karen; Ochia, C; Ar, Moss; Jm, Palefsky

doi:10.1016/0020-7292(94)90475-8

Cited by 102 publications

(103 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, the increased incidence of AIN in immunodeficient individuals seems to be related to the greater persistence of the virus in these patients. Several studies have reported a two to six times greater prevalence of HPV infection in immunosuppressed patients [23][24][25][26][27][28] and twice the risk of progression from low-grade AIN to high-grade AIN. [27][28][29][30] AIN lesions are known to advance from low-grade to high-grade AIN within 2 years of diagnosis in 36-66% of individuals with progression occurring more rapidly and more frequently in immunodeficient individuals.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies

et al. 2010

View full text Add to dashboard Cite

Human papillomavirus (HPV) infection strongly correlates with the development of anal intraepithelial neoplasias and carcinomas; however, few studies have characterized the distribution of the specific subtypes of the virus in the varying grades of dysplasia. This report characterizes the distribution of HPV 16/18 in surgical specimens with anal intraepithelial neoplasia (AIN) I-III and histological variants of anal carcinoma. A total of 111 anal surgical specimens with no dysplasia (10), AIN I-III (53), and anal carcinomas (48) were evaluated for the presence of high-risk HPV infection and subtyped by nested PCR or the Invader Assay. High-risk virus types were detected in progressively greater number of anal intraepithelial lesions from 56% in low grade to 88% in high grade. Type 16 was the prevalent subtype and was noted in 28% of low grade and 68% of high-grade lesions. Moderate dysplasias showed type 16 in 20%, a prevalence similar to that in low-grade lesions. The non-16/18 subtypes of the virus predominated and were present in 50% of the cases. Most (89%) squamous carcinomas were associated with high-risk viruses, 68% with type 16, a prevalence similar to that noted in highgrade dysplasia. Non-16/18 subtypes were encountered more frequently in squamous carcinomas from immunodeficient individuals (57% cases) as compared with immunocompetent individuals (18% cases). The similarity in the prevalence of type 16 in high-grade dysplasia and squamous carcinomas suggests that anal intraepithelial lesion III is the true precursor of squamous carcinoma and warrants aggressive management. Anal intraepithelial lesions II showed a virus distribution that was similar to low-grade dysplasia. In addition, a subset of these that were associated with type 16 or 18 showed progression, whereas those associated with non-16/18 subtypes regressed, thereby raising the possibility of conservative management for these lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies

et al. 2010

View full text Add to dashboard Cite

show abstract

“…5,10 Similar to cervical carcinoma, HPV infection plays a significant role in the development of anal condyloma, AIN, and anal carcinoma. 2,3,9,[17][18][19][20] It is notewor- thy that koilocytes, a common finding in cervicovaginal cytology, were less frequent and were observed in only 16 (21%) specimens. Other studies have reported the absence of koilocytosis in anorectal smears despite the presence of AIN.…”

Section: Table 4 Summary Of Cytologic Features Of Anorectal Specimensmentioning

confidence: 99%

Anorectal cytology as a screening tool for anal squamous lesions

Friedlander

Stier

Lin

2003

Cancer

View full text Add to dashboard Cite

“…This higher frequency of abnormal findings is also related to the concomitant presence of altered cervical cytology and lower levels of CD4 counts. 27,28 …”

Section: Risk Factors Implicated In Anal Intraepithelial Neoplasiamentioning

confidence: 99%

HPV infection and intraepithelial lesions from the anal region: how to diagnose?

Carvalho¹,

Ferreira²,

Bueno³

2011

Braz J Infect Dis

View full text Add to dashboard Cite

In the last years, the prevalence of HPV infection in the anal region has increased, especially in some groups like homosexual and HIV-positive people. Since this infection can be associated with the development of squamous anal cancer due to its progression from HPV infection to anal intraepithelial neoplasia (AIN) and finally to cancer, the screening and evaluation of these conditions are important. Anal cytology and high resolution anoscopy are good methods that are available and can be used. Although useful, these methods should be performed correctly and not indiscriminately in all patients. Patients for whom anal cytology screening is recommended are: HIV-infected patients, homosexuals, women who present with high-grade vulvar squamous intraepithelial neoplasia, vulvar cancer or cervical cancer. An abnormal anal cytology should be further evaluated with high resolution anoscopy. Keywords: anal canal; papillomavirus infections; cell biology; carcinoma in situ.identify these pre-invasive lesions is being questioned. Such questions relate to the groups to be screened and the best way to implement it such screening. The purpose of this study was to review the literature about the use of anal cytology and anoscopy to screening and evaluation of anal intraepithelial neoplasia. ANAL CYTOLOGYAnal cytology is a noninvasive method of screening, which is performed primarily by anal secretion collection through a brush (Dacron swab) introduced into the anal canal and removed with gentle rotation movements. It is indicated to avoid anal sex and douching in the day before the procedure, since these practices can decrease cellular recovery. Special caution should be taken for not touching anal canal warts and rectum walls with the brush to avoid any fecal contamination.

show abstract

Anal and cervical human papillomavirus infection and risk of anal and cervical epithelial abnormalities in human immunodeficiency virus‐infected women

Cited by 102 publications

References 0 publications

Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies

Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies

Anorectal cytology as a screening tool for anal squamous lesions

HPV infection and intraepithelial lesions from the anal region: how to diagnose?

Contact Info

Product

Resources

About