Anal canal gastrointestinal stromal tumour (GIST)

Abstract

SummaryGastrointestinal stromal tumours (GISTs) are malignant mesenchymal tumours that originate from the interstitial pacemaker cells of Cajal. They are particularly rare, comprising only 5% of all GISTs, and often present at an advanced stage. Treatment for these tumours is still a topic of debate due to their low incidence and insidious location. A woman in her mid-70s presented with rectal bleeding and anal discomfort. A 4.5×4 cm anal GIST was diagnosed. A local excision was performed and the patient was further treated with tyrosine kinase inhibitors. At a 6-month follow-up, the MRI showed that she was disease free. Anorectal GISTs are unusual and tend to be aggressive. Surgical resection is the first-line treatment for primary, localised GISTs. However, the appropriate surgical technique for these tumours is still a topic of debate. Further studies are needed to fully understand the oncologic behaviour of these rare neoplasms.

Adjuvant therapy for rare rectal gastrointestinal stromal tumors: A case report

“…Potential surgical options include minimally invasive techniques such as transanal, transvaginal, and transsacral excisions, as well as complete excision through low anterior or abdominoperineal resection. 14 Thus, a sphincter-saving approach is recommended for the treatment of rectal GISTs. In cases of small lower rectal tumors (up to 3 × 3 cm) with minimal invasion beyond the rectum, the preferred surgical approach is the transanal option.…”

“…The surgical approach for anorectal GISTs depends on multiple factors, including the size and location of the tumor (especially its distance from the dentate line) and the individual characteristics of the patient. Potential surgical options include minimally invasive techniques such as transanal, transvaginal, and transsacral excisions, as well as complete excision through low anterior or abdominoperineal resection 14 …”

“…Potential surgical options include minimally invasive techniques such as transanal, transvaginal, and transsacral excisions, as well as complete excision through low anterior or abdominoperineal resection. 14 …”