Multiple treatments have been described for fistula-in-ano; however, the ideal treatment remains elusive. The treatment of fistula-in-ano is a tightrope walk between preserving continence and preventing recurrence. A 70-year-old male patient from Mumbai (India) was suffering pilonidal sinus along with fistula-in-ano for 3 years. Kshar Sutra thread was used for the treatment. No internal medication was given for wound healing or infection control. There were no complications, such as infection, severe pain, or severe bleeding, and incontinence after the procedure. The patient was completed cured and is disease free for the last 5 years. Kshar Sutra is an effective treatment without any complications with complete healing.