Anal human papillomavirus genotype diversity and co-infection in a community-based sample of homosexual men

Vajdic, Claire M.; Leeuwen, Marina T. van; Jin, Fengyi; Prestage, Garrett; Medley, Gabriele; Hillman, Richard J.; Stevens, Matthew P.; Botes, Leon P.; Zablotska, Iryna; Tabrizi, Sepehr N.; Grulich, Andrew E.

doi:10.1136/sti.2008.034744

Cited by 87 publications

(92 citation statements)

References 26 publications

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“…3 The prevalence of anal HPV in HIV-positive MSM is often double that in HIV-negative men. 4,5 As CD4 cell counts decrease, the prevalence of HPV infection, the number of HPV types per individual, and the rate of cellular dysplasia increase. 6 The risk of invasive and in situ anal carcinoma in HIV-positive MSM is 37.9 and 60.1 times greater than men in the general population, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…4,5,36,37 Our findings confirm these associations: HIV-positive MSM were coinfected with more than twice as many HPV types as HIV-negative MSM [5.4 vs. 2.3 HPV types ( p < 0.001)]. The range of the most common HPV types also differed by HIV status: HIV-infected MSM were most commonly infected by types 58, 16, 11, and 6 while HIVnegative MSM were more commonly infected with types 6, 16, 54, and 62.…”

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confidence: 99%

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Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru

Quinn

Salvatierra

Solari

et al. 2012

AIDS Research and Human Retroviruses

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Human papillomavirus (HPV) infection among men who have sex with men (MSM) is the primary risk factor for anal cancer. Of 105 Peruvian MSM examined, 77.1% were infected with HPV; of these 79.0% were coinfected with two or more types and 47.3% were infected by a carcinogenic type. HPV types 53, 6, 16, and 58 were the most frequent HPV infections detected. High-risk HPV type infection was associated with sex work, HIV status, and having rectal chlamydial or gonorrheal infection. These findings support broadening HPV vaccine coverage and increasing surveillance for the development of cancer in MSM infected with HPV.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru

Quinn

Salvatierra

Solari

et al. 2012

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

show abstract

“…42 The first of these risk factors is a history of receptive anal intercourse. Anal HPV infection is almost universal in sexually active gay men in Australia, 46 and rates of anal cancer are~30-fold higher in homosexual men compared with other men. 47 Immune deficiency leads to disturbed control of anal HPV infection, and rates of anal cancer are increased~30-fold in men and women with HIV and~5-fold in organ transplant recipients receiving immune suppressive medication.…”

Section: Anal Cancermentioning

confidence: 99%

Cancers attributable to human papillomavirus infection

et al. 2010

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Abstract. Although the human papillomavirus (HPV) vaccine was introduced primarily as a cervical cancer prevention vaccine, HPV has a causal role in several types of cancer. This article reviews the epidemiological evidence for the role of HPV in human cancer, and describes Australian trends in these cancers. HPV is a necessary cause of cervical cancer. The currently vaccine-preventable subtypes of HPV 16 and 18 are responsible for~70% of cervical cancer. The introduction of an organised Pap smear program in Australia led to a steep decline in incidence over the past decades. HPV can be detected in~40% and 70% of vulval and vaginal cancers respectively. Rates of these cancers have been stable over the past 20 years. The prevalence of HPV in penile cancer is~50% and incidence has not recently changed. For anal cancer,~85% of cases are HPV positive, and incidence has increased significantly in both men and women over the past 20 years. In the oral cavity,~35% of oropharyngeal cancers and~25% of other oral cavity cancers are HPV positive. The incidence of HPV-related oral cavity and oropharyngeal cancers is increasing, whereas incidence at HPV-unrelated sites is decreasing. Overall, 1154 HPV-related cancer cases were potentially preventable by vaccination. If HPV-related cancers at non-cervical sites are prevented by vaccination, then a similar number of cancer cases will be prevented as in the cervix. However, almost one-quarter of the potentially preventable cancer cases are in men, who are not included in the current national immunisation program.

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“…Given the tremendous prevalence of anal HPV DNA in HIV-positive patients (85-97%) [8,9], routine anal HPV testing is not currently part of any recommended screening program. However, only scarce data are available on the natural history of anal HPV infection and cancer [6].…”

Section: Introductionmentioning

confidence: 99%

Feasibility and Acceptability of Anal Self-Sampling for Human Papillomavirus Screening in HIV-Infected Patients

et al. 2016

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Objectives: Anal cancer incidence is increasing among HIV-positive patients. No consensus currently exists for the screening of anal dysplasia. This study aimed at evaluating the feasibility and acceptability of anal self-sampling and assessing the prevalence of human papillomavirus (HPV) types among HIV-positive patients from Marseille University Hospitals. Methods: Between October 2013 and March 2014, during their regular visits for the monitoring of their HIV infection in an HIV outpatient clinical unit of Marseille University Hospitals, patients were asked to self-sample anal swabs for HPV detection. A specimen self-collection kit was provided. HPV detection and genotyping were performed using in-house protocols. The quality of self-sampling was assessed by concurrent cellular quantification in collected samples. Results: The acceptability rate of anal self-sampling was 91%, and 91% of the self-sampled specimens were appropriate for HPV screening. In addition, 76% of the samples were positive for HPV, including 54% of HPV types with oncogenic potential. Conclusions: This study indicates that HPV detection and typing through anal self-sampling is a valuable strategy to screen patients at high risk for anal cancer development. This could allow earlier management of anal lesions and related cancer in patients at high risk for HPV.

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Anal human papillomavirus genotype diversity and co-infection in a community-based sample of homosexual men

Cited by 87 publications

References 26 publications

Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru

Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru

Cancers attributable to human papillomavirus infection

Feasibility and Acceptability of Anal Self-Sampling for Human Papillomavirus Screening in HIV-Infected Patients

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