Analgesia effect of baicalein against NTG-induced migraine in rats

Zhang, Xiaofan; Zhang, Wenjun; Dong, Cui‐Lan; Hu, Wan-Li; Sun, Yu-Yao; Bao, Yarigui; Zhang, Chunfeng; Guo, Chengjun; Wang, Chong‐Zhi; Yuan, Chun‐Su

doi:10.1016/j.biopha.2017.03.052

Cited by 16 publications

(7 citation statements)

References 33 publications

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“…2,7,8 In addition, to examine migraine, protooncogene c-fos expression has also been widely used as a marker for neuronal activation in brainstem. 27,29 In the present study, in vivo application of GTN significantly induced an increase in the CGRP levels both in plasma and the trigeminal ganglion neurons. Moreover, it also caused an increased expression of c-fos in trigeminal nucleus caudalis in rat models of migraine.…”

Section: Cgrp Release and C-fos Expression After In Vivo Applicatiosupporting

confidence: 56%

“…The increase in the plasma levels of CGRP is a biomarker for trigeminovascular activation during migraine attacks and cluster headaches . In addition, to examine migraine, proto‐oncogene c‐fos expression has also been widely used as a marker for neuronal activation in brainstem . In the present study, in vivo application of GTN significantly induced an increase in the CGRP levels both in plasma and the trigeminal ganglion neurons.…”

Section: Discussionmentioning

confidence: 54%

“…Our results are in line with the recently published studies reporting that GTN-induced CGRP release in plasma as well as expression of c-fos in TNC of rats. 29,30 It was reported that blood levels of CGRP in the internal jugular vein of migraine patients were raised to their maximum value at the first hour after the onset of migraine attack. 31 We showed for the first time that in vivo administration of GTN…”

Section: Cgrp Release and C-fos Expression After In Vivo Applicatiomentioning

confidence: 99%

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Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats

Kılınç

Dağıstan

Kükner

et al. 2018

Clin Exp Pharma Physio

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The exact mechanism of migraine pathophysiology still remains unclear due to the complex nature of migraine pain. Salmon calcitonin (SC) exhibits antinociceptive effects in the treatment of various pain conditions. In this study, we explored the mechanisms underlying the analgesic effect of salmon calcitonin on migrane pain using glyceryltrinitrate (GTN)-induced model of migraine and ex vivo meningeal preparations in rats. Rats were intraperitoneally administered saline, GTN (10 mg/kg), vehicle, saline + GTN, SC (50 μg/kg) + GTN, and SC alone. Also, ex vivo meningeal preparations were applied topically 100 μmol/L GTN, 50 μmol/L SC, and SC + GTN. Calcitonin gene-related peptide (CGRP) contents of plasma, trigeminal neurons and superfusates were measured using enzyme-immunoassays. Dural mast cells were stained with toluidine blue. c-fos neuronal activity in trigeminal nucleus caudalis (TNC) sections were determined by immunohistochemical staining. The results showed that GTN triggered the increase in CGRP levels in plasma, trigeminal ganglion neurons and ex vivo meningeal preparations. Likewise, GTN-induced c-fos expression in TNC. In in vivo experiments, GTN caused dural mast cell degranulation, but similar effects were not seen in ex vivo experiments. Salmon calcitonin administration ameliorated GTN-induced migraine pain by reversing the increases induced by GTN. Our findings suggested that salmon calcitonin could alleviate the migraine-like pain by modulating CGRP release at different levels including the generation and conduction sites of migraine pain and mast cell behaviour in the dura mater. Therefore salmon calcitonin may be a new therapeutic choice in migraine pain relief.

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Section: Cgrp Release and C-fos Expression After In Vivo Applicatiosupporting

confidence: 56%

Section: Discussionmentioning

confidence: 54%

Section: Cgrp Release and C-fos Expression After In Vivo Applicatiomentioning

confidence: 99%

See 1 more Smart Citation

Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats

Kılınç

Dağıstan

Kükner

et al. 2018

Clin Exp Pharma Physio

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“…The symptoms of migraine include head scratching, cage climbing, tremor, ear redness, irritability, etc. ( Hou et al, 2017 ; Zhang et al, 2017 ). Behavioral results showed that after subcutaneous injection of NTG, migraine rats seemed to be more active, and after emodin was given, the number of head scratching and cage climbing within 90 min was significantly reduced.…”

Section: Discussionmentioning

confidence: 99%

“…( n = 6, half coronal cut, half sagittal cut). The specific operation of immunohistochemistry was completed according to a previous study (X. F. Zhang et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Emodin Interferes With Nitroglycerin-Induced Migraine in Rats Through CGMP-PKG Pathway

et al. 2021

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The purpose of this research was to explore the effect and mechanism of emodin in interfering with nitroglycerin-induced migraine rats. We carried out behavioral research within 2 h post-nitroglycerin (NTG) injection, and blood samples were collected through the abdominal aorta for measurements of nitric oxide (NO), calcitonin gene-related peptide (CGRP), substance P (SP), tumor necrosis factor (TNF-α) and cyclic guanosine monophosphate (cGMP) levels. Immunohistochemistry was adopted to detect the activation of c-Fos immunoreactive neurons in brain tissues. The number and integrated optical density (IOD) of c-Fos positive cells were measured using Image-Pro Plus. Western blotting was applied to detect the levels of PKG protein in rat brain tissues. The results showed that emodin can alleviate the pain response of migraine rats and significantly reduce the levels of NO, CGRP, SP, TNF-α and cGMP in migraine rats. In addition, emodin can significantly reduce the number of c-Fos positive cells and the IOD value. Moreover, the expression of PKG protein was significantly inhibited by emodin. Therefore, it is inferred that emodin can relieve migraine induced by NTG through the cGMP-PKG pathway, and can be used as a potential botanical medicine for the treatment of migraine.

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Role of herbal medicine for prevention and treatment of migraine

Chen

Wang

2021

Phytotherapy Research

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Migraine is a disabling neurovascular disease with unilateral or bilateral pulsatile headache, which intensively affects human health and quality of life due to high morbidity worldwide. Migraine is commonly accompanied by abnormal pain sensitization, neuroinflammatory response, and vasomotor dysfunction. Owing to the management dilemmas of migraine, there is an urgent need to develop effective and low-cost therapies. In recent years, herbal medicines as a promising strategy with analgesic activity and minor side effect, have been proposed for the prevention and treatment of migraine. Considering the lack of a review integrating experimental studies regarding the herbal treatment of migraine, this review systematically summarizes the important potential applications of herbal medicines in ameliorating migraine via multiple therapeutic targets and pathways, as well as provides a reference for further development of novel antimigraine drugs.

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Analgesia effect of baicalein against NTG-induced migraine in rats

Cited by 16 publications

References 33 publications

Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats

Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats

Emodin Interferes With Nitroglycerin-Induced Migraine in Rats Through CGMP-PKG Pathway

Role of herbal medicine for prevention and treatment of migraine

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