Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: behavioral observations and inhibitory effects on spinal cord interneurons

Liebeskind, John C.; Guilbaud, G.; Besson, Jean‐Marie; Olivéras, Jean-Louis

doi:10.1016/0006-8993(73)90748-8

Cited by 419 publications

(94 citation statements)

References 19 publications

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“…Such antinociception is thought to result in inhibition of nociceptive neurons in the dorsal horn (Liebeskind et al, 1973), directly and via the nucleus raphe magnus of the rostral ventromedial medulla (Gebhart et al, 1983). Thus, the periaqueductal gray modulates the amount of nociceptive information which is transmitted to higher brain centres, and hence, affects the magnitude of pain experienced.…”

Section: Supraspinal Modulation Of Pain-mentioning

confidence: 99%

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Edwards

Ring

Al’Absi

et al. 2007

Biological Psychology

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Supraspinal pain modulation may explain hypertensive hypoalgesia. We compared nociceptive flexion reflex (NFR) thresholds and pain during rest and computer game play in hypertensives and normotensives (Experiment 1) and normotensives with and without hypertensive parents (Experiment 2). The game was selected to modulate activity in pain pathways. NFR thresholds did not differ between groups during rest or game play. Pain ratings never differed between hypertensives and normotensives, whereas individuals with hypertensive parents reported less pain during the first two NFR assessments, compared to those without. NFR thresholds and pain were reduced by game play compared to rest. The failure of game play to differentially modulate NFR thresholds or associated pain reports between groups argues against enhanced supraspinal modulation of nociception and pain in hypertensives and those at increased risk for hypertension.

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Section: Supraspinal Modulation Of Pain-mentioning

confidence: 99%

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Edwards

Ring

Al’Absi

et al. 2007

Biological Psychology

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“…Integrative functions of PAG PAG has been strongly implicated in pain modulation (Reynolds, 1969;Liebeskind et al, 1973;Oliveras et al, 1974;Behbehani and Fields, 1979;Lovick, 1985;Reichling et al, 1988), vocalization (Jiirgens and Pratt, 1979;Larson and Kistler, 1984;Larson, 1985;Larson and Kistler, 1986;Jiirgens, 1991;Davis et al, 1993), blood pressure regulation (Lovick, 1985;Carrive et al, 1987;Carrive et al, 1989a;Lovick, 1990;Verberne and Guyenet, 1992;Murphy et al, 1994aMurphy et al, , 1995, regional blood flow Carrive et al, 1989b;Carrive and Bandler, 1991), and mobility Bandler et al, 1991). These autonomic, sensory, and behavioral adjustments are all engaged during reproductive behaviors.…”

Section: Reproductivementioning

confidence: 99%

“…PAG plays a key role in antinociception (Reynolds, 1969;Liebeskind et al, 1973;Oliveras et al, 1974;Behbehani and Fields, 1979; Lovick, 3985;Morgan and Liebeskind, 1987;Reichling et al, 1988;Lovick, 1990), cardiovascular control (Lovick, 1985;Carrive et al, 1987;Carrive et al, 1988;Carrive et al, 1989a;Lovick, 1990;Verberne and Guyenet, 1992;Murphy et al, 1994a;Murphy et al, 1995), and many of the same neuroendocrine and reproductive functions as MPO (Pfaff and SchwartzGiblin, 1988;Ogawa et al, 1991;Shipley et al, 1995). PAG neurons involved in these functions also are organized in a columnar manner (for review, see Bandler and Shipley, 1994).…”

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confidence: 99%

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

et al. 1996

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We have shown recently that the medial preoptic area (MPO) robustly innervates discrete columns along the rostrocaudal axis of the midbrain periaqueductal gray (PAG). However, the location of PAG neurons responsive to MPO activation is not known. Anterograde tract tracing was used in combination with Fos immunohistochemistry to characterize the MPO -+ PAG pathway anatomically and ,functionally within the same animal. Focal electrical or chemical stimulation of MPO in anesthetized rats induced extensive Fos expression within the PAG compared with sham controls. Fos-positive neurons were organized as 2-3 longitudinal columns. The organization and location of these columns overlapped remarkably well with the distribution of fibers and terminals in PAG labeled by Phaseolus vulgaris leucoagglutinin (PHA-L) injected into the same MPO stimulation site. This indicates that MPO inputs may terminate on the soma or proximal dendrites of neurons exhibiting elevated Fos. A second series of experiments investigated whether MPO stimulation excited PAG neurons with descending projections to the medulla. Retrograde labeling of PAG neurons projecting to the medial and lateral regions of the rostroventral medulla (RVM) was combined with MPO-induced Fos expression. The results showed that a substantial population (3743%)of Fos-positive PAG neurons projected to the ventral medulla. This indicates that MPO stimulation engages PAG-medullary output neurons. Taken together, these results suggest that the MPO + PAG + RVM projection constitutes a functional pathway. This circuit may coordinately regulate neuroendocrine, motor, and autonomic adjustments necessary for the elaboration of sexual behaviors.Key words: reproduction; antinociception; cardiovascular regulation; brainstem; sexual behavior; immunohistochemistryThe medial preoptic area (h/[PO) is a sexually dimorphic structure Simerly et al., 1984;Bloch and Gorski, 1988) that plays a pivotal role in sexual behavior and neuroendocrine function (Lisk, 1966;Powers and Valenstein, 1972;Pfaff and Sakuma, 1979;Hansen et al., 1982;Arendash and Gorski, 1983;Kalra and Kalra, 1983;Docke et al., 1984;Sachs and Meisel, 1988;Simerly et al., 1990;DonCarlos et al., 1991;Takeo et al., 1993;Hoshina et al., 1994). We recently reported that MPO robustly innervates the midbrain periaqueductal gray (PAG) (Rizvi et al., 1992) and terminates in discrete, longitudinally organized columns running through the rostrocaudal axis of PAG.PAG plays a key role in antinociception (Reynolds, 1969;Liebeskind et al., 1973;Oliveras et al., 1974;Behbehani and Fields, 1979; Lovick, 3985;Morgan and Liebeskind, 1987;Reichling et al., 1988;Lovick, 1990), cardiovascular control (Lovick, 1985;Carrive et al., 1987;Carrive et al., 1988;Carrive et al., 1989a;Lovick, 1990;Verberne and Guyenet, 1992;Murphy et al., 1994a;Murphy et al., 1995), and many of the same neuroendocrine and reproductive functions as MPO (Pfaff and SchwartzGiblin, 1988;Ogawa et al., 1991;Shipley et al., 1995). PAG neurons involved in these functions also are ...

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“…Electrical stimulation of the PAG in man produces analgesia (Hosobuchi et al, 1977;Richardson and Akil, 1977) and inhibits responses to noxious stimuli in rats, cats, and monkeys (Reynolds, 1969;Mayer and Liebeskind, 1974;Oliveras et al 1974; Lewis and Gebhart, 1977;Gebhart and Toleikis, 1978;Hayes et al, 1979). The PAG has relatively high concentrations of opiate binding sites (Atweh and Kuhar, 1977), as well as of endogenous opioid peptides (Uhl et al, 1977;Sar et al, 1978;Finley et al, 1981a;Moss et al, 1983) and direct injection of opiate agonists into the PAG suppresses behavioral and neuronal responses to noxious stimulation (Liebeskind et al, 1973;Jacquet and Lajtha, 1976;Lewis and Gebhart, 1977;Yeung et al, 1977;Yaksh and Rudy, 1978;Bennett and Mayer, 1979;Cheng et al, 1986).…”

mentioning

confidence: 99%

Evidence for two classes of nociceptive modulating neurons in the periaqueductal gray

Heinricher¹,

Cheng²,

Fields³

1987

J. Neurosci.

111

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The midbrain periaqueductal gray (PAG) and the rostral ventromedial medulla (RVM) are important links in a neuronal network that modulates nociceptive transmission. In the RVM, 2 classes of cells have been identified that show changes in activity at the time of the tail-flick response (TF) elicited by noxious heat (Fields et al., 1983a). We now report that neurons in the PAG region also show changes in activity related to TF. Extracellular recordings were made from the PAG and the ventrally adjacent tegmentum at sites from which it was possible to inhibit TF using stimulating currents of 10 microA or less. Cell activity, time of TF occurrence, and tail temperature were recorded during 5 repetitions of the heat stimulus. Periresponse and peristimulus histograms were plotted with reference to the TF and tail temperature, respectively. A significant number of neurons in the PAG region showed changes in activity that preceded the TF. “Midbrain On- cells” (13.6% of the sample) displayed an abrupt increase in firing just prior to the TF. “Midbrain Off-cells” (4.4%) paused just prior to the TF. The remaining neurons (241 of 294, or 82%) did not exhibit changes in firing prior to the TF. Thus, cells with changes in activity related to the TF are present in the PAG region as well as in the RVM. The PAG has a large projection to the RVM, and microinjection of morphine in the PAG increases activity of RVM Off-cells and decreases that of RVM On-cells.(ABSTRACT TRUNCATED AT 250 WORDS)

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Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: behavioral observations and inhibitory effects on spinal cord interneurons

Cited by 419 publications

References 19 publications

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

Evidence for two classes of nociceptive modulating neurons in the periaqueductal gray

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