Analgesia in defeated mice: Evidence for mediation via central rather than pituitary or adrenal endogenous opioid peptides

Thompson, Michael L.; Miczek, Klaus A.; Noda, Kyohei; Shuster, Louis; Kumar, Mrinal

doi:10.1016/0091-3057(88)90002-0

Cited by 14 publications

(2 citation statements)

References 32 publications

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“…The results suggest the compelling notion that the engagement of m-OR in the LC during social stress can render the neurons opiate tolerant and dependent, conditions that would promote self-administration. Notably, a body of literature has described tolerance to opioid analgesia following this same stress (Miczek, 1991; Miczek, Thompson, & Shuster, 1986; Thompson, Miczek, Noda, Shuster, & Kumar, 1988). …”

Section: Dysregulation Of the Lc-ne System By An Imbalance In Endmentioning

confidence: 99%

Neuropeptide Regulation of the Locus Coeruleus and Opiate-Induced Plasticity of Stress Responses

Bockstaele

Valentino

2013

A New Era of Catecholamines in the Laboratory and Clinic

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Stress has been implicated as a risk factor in vulnerability to the initiation and maintenance of opiate abuse and is thought to play an important role in relapse in subjects with a history of abuse. Conversely, chronic opiate use and withdrawal are stressors and can potentially predispose individuals to stress-related psychiatric disorders. Because the interaction of opiates with stress response systems has potentially widespread clinical consequences, it is important to delineate how specific substrates of the stress response and endogenous opioid systems interact and the specific points at which stress circuits and endogenous opioid systems intersect. The purpose of this review is to present and discuss the results of studies that have unveiled the complex circuitry by which stress-related neuropeptides and endogenous opioids co-regulate activity of the locus coeruleus (LC)-norepinephrine (NE) system and how chronic morphine, or stress, disturbs this regulation.

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Section: Dysregulation Of the Lc-ne System By An Imbalance In Endmentioning

confidence: 99%

Neuropeptide Regulation of the Locus Coeruleus and Opiate-Induced Plasticity of Stress Responses

Bockstaele

Valentino

2013

A New Era of Catecholamines in the Laboratory and Clinic

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“…Yet, only the defeated, but not the victorious animals, even when matched for corticosterone values, show analgesia ). Moreover, adrenalectomy and other experimental compromises of either adrenal or pituitary function left the analgesic response in defeated mice intact (Thompson et al 1987). Exposure to stress results in the secretion of opioid peptides from cells of the anterior lobe of the pituitary gland, and also from the chromaffin cells in the adrenal medulla.…”

Section: Iominmentioning

confidence: 99%

Analgesia and decrement in operant performance in socially defeated mice: Selective cross-tolerance to morphine and antagonism by naltrexone

Miczek

Winslow

1987

Psychopharmacology

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During a social confrontation between a resident and an intruder mouse, only the submissive or defeated intruder shows an opioid-mediated analgesia to which tolerance develops. We investigated the altered morphine responsiveness after different kinds of social experiences. Mice were assessed for performance of operant behavior under the control of a fixed ratio schedule of positive reinforcement as well as for the tail flick response to a heat stimulus before and after one or five consecutive social confrontations. The dose-effect curves for morphine's suppression of schedule-controlled behavior were closely similar before and after defeat in a single or in five social confrontations. However, the concurrently measured response to pain in the tail flick assay produced morphine dose-effect curves that were shifted to the right after defeat in one or five social confrontations. Four to six times higher doses of morphine were necessary to produce analgesia in mice that were defeated in five social confrontations. Naltrexone (1 mg/kg, ip) antagonized the suppressive effects of morphine (10 mg/kg, ip) on rate of responding and the analgesic effects. Naltrexone also blocked the development of analgesia in mice that were defeated for the first time in a social confrontation, but did not prevent the suppressive effects on rate of responding. Specific social experiences such as defeat in a social confrontation appear to alter endogenous opioid process that mediate analgesia; these processes differ from those that suppress positively reinforced behavior. The differential development of morphine tolerance to the analgesic effects, but not the rate-decreasing effects as well as the differential naltrexone antagonism of both effects may indicate the involvement of opioid and non-opioid mechanisms.

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Neuropharmacological aspects of adaptive pain inhibition in murine “victims” of aggression

Rodgers

1995

Aggr. Behav.

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This review outlines recent research on a subset of physiological responses in murine “victims” or aggression. In a typical resident‐intruder paradigm, the detailed study of intruders has revealed that exposure to conspecific attack (and related stimuli) is associated with two forms of analgesia which appear to be integral components of the murine defensive repertoire. In response to intense/enduring attack, intruder mice display a profound, long‐lasting and opioid‐mediated analgesia. This reaction is highly correlated with defensive immobility and may function to reduce involuntary cues to further attack. In contrast, the inhibition of pain reactivity in mice tested immediately upon the display of defeat is less intense, shorter‐lasting, non‐opioid in nature and may function to facilitate active defenses such as escape. As this form of pain inhibition is also evident in intruders exposed to the scent of an aggressive male conspecific, a possible anticipatory defensive function linked to mechanisms of anxiety has been proposed. This hypothesis is supported by 1) the prevention of defeat analgesia by a range of antianxiety drugs (benzodiazepines, 5‐hydroxytryptamine1A [5‐HT1A] receptor agonists, and 5‐HT3 receptor antagonists) and 2) the effects of social defeat on behavior in the elevated plusmaze model of anxiety. These findings are discussed in relation to coping mechanisms in murine “victims” of aggression. © 1995 Wiley‐Liss, Inc.

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Analgesia in defeated mice: Evidence for mediation via central rather than pituitary or adrenal endogenous opioid peptides

Cited by 14 publications

References 32 publications

Neuropeptide Regulation of the Locus Coeruleus and Opiate-Induced Plasticity of Stress Responses

Neuropeptide Regulation of the Locus Coeruleus and Opiate-Induced Plasticity of Stress Responses

Analgesia and decrement in operant performance in socially defeated mice: Selective cross-tolerance to morphine and antagonism by naltrexone

Neuropharmacological aspects of adaptive pain inhibition in murine “victims” of aggression

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