Analgesic Activities of Methanol Extract of &amp;lt;i&amp;gt;Terminalia chebula&amp;lt;/i&amp;gt; Fruit

Ahmed, Sadaf; Naved, Auroj; Khan, Rafeeq Alam; Siddiqui, Shahida Anusha

doi:10.4236/pp.2015.612056

Cited by 18 publications

(16 citation statements)

References 16 publications

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“…Aspirin 300 mg tablets were trampled and suspended in gum tragacanth (2%) which was then administered per oral through orogastric tube in a dose of 50, 100 and 200 mg/kg in tail flick test and acetic acid-induced writhing test [21]. 0.7% acetic acid in the dose of 10 ml/kg was administered IP [22].…”

Section: Preparation Of Extract/chemicalsmentioning

confidence: 99%

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Assessment of Analgesic Activity of Nelumbo Nucifera Fruit Ethanol Extract

Rajput

Zehra

Ali

et al. 2019

Int J Pharm Pharm Sci

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Objective: Utilization of herbal remedies rich in flavonoids and vitamins have increased significantly these days to treat various disorders, thus existing research work encircled to appraise the analgesic effect of Nelumbo nucifera fruit (NNF) for evaluating its traditional use pharmacologically in disorders which are associated with pain and inflammation. Methods: Central analgesic activity in mice was assessed by tail flick test and the latency time i.e. the removal of tail from the stimulus was recorded. Similarly acetic acid induced writhing test was also conducted for the assessment of peripheral analgesic effect in mice and number of writhes was counted along with percent inhibition of writhes. Results: In tail flick test the peek anti-nociceptive effect at all doses of fruit was observed at 90 min. However, the percentage of tail elongation time was highest at a dose of 200 mg/kg i.e. 82% at 90 min. Number of writhes was highly significantly reduced at all doses of NNF but maximum effects were observed at dose 200 mg/kg as compared to control, indicating 48.41 % inhibition of writhes. Conclusion: NNF have exhibited strong analgesic effect in both animal models, which may be connected with the synergistic actions of flavonoids, saponins and tannins on arachidonic acid pathway inhibition. Hence NNF seems to have a great potential in disorders associated with pain but more experimental trials in this field are required to confirm these findings.

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Section: Preparation Of Extract/chemicalsmentioning

confidence: 99%

“…Analgesia is the loss of ability to feel or react to painful stimulus such as chemical, thermal or mechanical [21]. In the current study central analgesic activity in mice was assessed by tail-flick test and tail-flick latency difference (TFLD) i.e.…”

Section: Tail Flick Testmentioning

confidence: 99%

Assessment of Analgesic Activity of Nelumbo Nucifera Fruit Ethanol Extract

Rajput

Zehra

Ali

et al. 2019

Int J Pharm Pharm Sci

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“…However, very limited literature is available regarding its effect on lipid profile, thus current study was focused to determine the anti-hyperlipidemic potential of N. nucifera fruit in rabbits fed with high cholesterol diet. This study would surely help in the exploration of a novel agent from the plant source and therefore may recommend the application of complimentary medicines in humans [10].…”

Section: Introductionmentioning

confidence: 96%

Evaluation of the Anti-Hyperlipidemic Activity of <i> Nelumbo nucifera </i>Fruit in Rabbits Fed with High Cholesterol Diet

Rajput¹,

Khan²,

Assad³

2017

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Recently use of herbal therapies and diet rich in flavonoids and vitamins has augmented significantly to manage minor to modest illnesses. Several anti-hyperlipidemic agents are currently available; however most of them have various unwanted effects. That's why more people are switching towards safer alternatives, specially derived from plants with fewer side effects. Hence current study was focused to determine the anti-hyperlipidemic potential of Nelumbo nucifera fruit in rabbits fed with high cholesterol diet. This study would surely help in the exploration of a novel agent from the plant source and therefore may recommend the application of traditional medicines in humans. 28 white healthy rabbits of either sex weighing 1000 -1500 gm were divided into four groups. Control group was given gum tragacanth and 3 groups served as test groups and were given N. nucifera fruit extract 50, 100 and 200 mg/kg for 45 days. Initially animals of all four groups received high cholesterol diet (HCD) 0.125 gm/kg cholesterol in 0.5% corn oil for 30 days. All drugs were given orally. Blood samples were taken thrice from the ear vein of animals, 1 st after 24 hours of thirty days of HCD then again after 24 hours of thirty and forty five days dosing of N. nucifera fruit extract. The results showed remarkable cholesterol lowering effects of N. nucifera fruit extract at doses 50, 100 and 200 mg/kg but were particularly dominant at 200 mg/kg at which fruit extract highly significantly reduced TC, TG and LDL-C after 30 and 45 days and increased HDL-C significantly after 30 days and highly significantly after 45 days. Flavonoids, saponins, tannins and procyanidin are significant constituents of N. nucifera fruit which may have contributed in lipid lowering effects of N. nucifera fruit which can contribute in lowering the risk of CVDs and stroke but more preclinical and clinical studies are required to confirm these findings.

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“…The pain pathway usually involves transduction, transmission, modulation and perception. Drugs commonly in use for pain management one classified as opioids analgesics and non-steroidal anti -inflammatory drugs 2 . The medicinal plants have been a major source of a wide variety of biologically active compounds for many centuries have been used extensively in crude form or as pure isolated compounds to treat inflammation 3 .…”

Section: Introductionmentioning

confidence: 99%

“…The extracts of the Adiantum leaves have anti-inflammatory, analgesic, anti-microbial activities 7. The hydro-alcoholic extract of leaves has strong anti-urolithic properties and isolated vascular endothelial growth factor and transforming growth factor beta-1 proteins in normal and streptozotocin-induced diabetic rats, during treatment of formulations of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha usually claimed 2,10 have been reported very good antidiabetic as well as low side effect at the different dose of aqueous extracts and methanolic extract, Hair growth-promoting activity was reported by 11 on albino mice using a testosterone-induced alopecia model and methanolic extract of whole plant showed the antibacterial activity 11 . Ethanolic extract have nephroprotective activity against cisplatin induced oxidative stress caused in male wistar rats 4 .…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive Activity of Adiantum Capillus in Experimental Animals

Khan¹,

Jawla²,

Hussain³

2019

Int. Res. J. Pharm.

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In present study 50% ethanolic extract of whole plant of Adiantum capillus (ACE) was evaluated for its analgesic and anti-inflammatory effects in animals at different doses 100, 200 and 300 mg/kg by different method. Eddy's hot plate method, writhing test, formalin test and carrageenan induced revealed that ACE possessed varying degree of analgesic and anti-inflammatory activity significant at 100, 200 and 300 mg/kg and highly significant at 300 mg/kg in comparison to control. In acetic acid induced writhing test, maximum inhibition of writhing was observed at 300 mg/kg where the number of writhes decreased from 40.32 to 18.32 indicating 54.56% inhibition. While formalin induced pain (0.05 ml of 2.5%) was significantly blocked only at higher dose (300 mg/kg) in first phase. ACE significantly blocked pain emanating from inflammation at all the doses in second phase. The reaction time in hot plate was increased significantly and dose dependently whereas pretreatment with diclofenac sodium reduced the analgesic potentials of ACE.

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Analgesic Activities of Methanol Extract of <i>Terminalia chebula</i> Fruit

Cited by 18 publications

References 16 publications

Assessment of Analgesic Activity of Nelumbo Nucifera Fruit Ethanol Extract

Assessment of Analgesic Activity of Nelumbo Nucifera Fruit Ethanol Extract

Evaluation of the Anti-Hyperlipidemic Activity of <i> Nelumbo nucifera </i>Fruit in Rabbits Fed with High Cholesterol Diet

Antinociceptive Activity of Adiantum Capillus in Experimental Animals

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Analgesic Activities of Methanol Extract of &lt;i&gt;Terminalia chebula&lt;/i&gt; Fruit

Cited by 18 publications

References 16 publications

Assessment of Analgesic Activity of Nelumbo Nucifera Fruit Ethanol Extract

Assessment of Analgesic Activity of Nelumbo Nucifera Fruit Ethanol Extract

Evaluation of the Anti-Hyperlipidemic Activity of &lt;i&gt; Nelumbo nucifera &lt;/i&gt;Fruit in Rabbits Fed with High Cholesterol Diet

Antinociceptive Activity of Adiantum Capillus in Experimental Animals

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Analgesic Activities of Methanol Extract of <i>Terminalia chebula</i> Fruit

Evaluation of the Anti-Hyperlipidemic Activity of <i> Nelumbo nucifera </i>Fruit in Rabbits Fed with High Cholesterol Diet