Analgesic activity of angiotensin antagonists

Indumathy, S

doi:10.5897/ajmr10.359

Cited by 8 publications

(6 citation statements)

References 10 publications

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“…The time taken for the animal to remove it tail out of the water was recorded. [15] Dosing schedule All the drugs are given according to their body weight once before starting the test.…”

Section: Tail Clip Testmentioning

confidence: 99%

Atorvastatin and simvastatin as analgesic agents in experimental models

S¹,

Kumar²,

Keerthi³

2012

J Basic Clin Pharma

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Objectives: 1) To evaluate the analgesic effect of atorvastatin and simvastatin. 2) To compare analgesic activity of these with an established drug tramadol. Materials and Methods: Healthy Albino rats were taken. They were randomly divided into 4 groups of six animals each. Group I: Normal Saline (0.5 ml), Group II: Tramadol (10 mg/kg BW), Group III: Atorvastatin (10 mg/kg BW) and Group IV: Simvastatin (10 mg/kg BW). The animals were subjected to 3 different tests at different interval of time. The tests conducted were tail clip method, Eddy's hot plate and hot water tail immersion method. Results: Atorvastatin and simvastatin differ signi icantly from control hence they have analgesic action and even at any of the time intervals they do not differ signi icantly from tramadol; hence their analgesic effect is nearly comparable to tramadol. The results of the present study indicate that atorvastatin and simvastatin have analgesic action. Conclusion: These statins are found to have analgesic effect other than hypolipidemic activity and can be used in these patients. However further study has to be undertaken in a broader way.

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“…The time taken for the animal to remove it tail out of the water was recorded. [15] Dosing schedule All the drugs are given according to their body weight once before starting the test.…”

Section: Tail Clip Testmentioning

confidence: 99%

Atorvastatin and simvastatin as analgesic agents in experimental models

S¹,

Kumar²,

Keerthi³

2012

J Basic Clin Pharma

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“…Telmisartan could exert central analgesic effect as angiotensin receptor antagonists may modulate the analgesic action by increasing the pain threshold or by central mechanism by altering the pain modulating neurotransmitter level and activation of AT1 receptor with AngII also increases Ca ++ influx: their blockade leads to analgesic activity. 12 Also Wang JF et. al reported that ARAs produce analgesia on intracerebro-ventricular administration in rats and this action can be blocked by naloxone.…”

Section: Results: Tail Flick Methodmentioning

confidence: 98%

Untitled

2015

IJPSR

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To study the analgesic activity of telmisartan in graded doses, in tail flick method and acetic acid induced writhing method in rats and mice respectively. Materials and Methods: Analgesic activity of telmisartan was evaluated in graded doses tail flick model (for central action) and acetic acid induced writhing model (for peripheral action) of analgesia. Aspirin & tramadol were used as standard drugs. Results were analyzed by one way ANOVA followed by Bonferroni's post hoc test. Results: In tail flick method telmisartan showed dose dependent analgesic activity. The tail flick latency time increased from 0 to 60 min. The analgesic activity of telmisartan at dose of 1.5mg/kg was not statistically significant, however it was statistically significant at dose 3mg/kg and 4.5 mg/kg. At the dose of 3mg/kg; telmisartan showed highly significant activity p<0.01 at 30, 60 as well as 90 min with maximum effect at 90min, where as the most significant effect p<0.001 was observed at the dose of 4.5mg/kg at 60 and 90min. In acetic acid induced writhing method, the telmisartan possessed significant analgesic activity at all three doses (1.5mg/kg, 3mg/kg and 4.5mg/kg) with maximum activity at the dose of 4.5mg/kg. Conclusion: Telmisartan an angiotensin II AT1 receptor antagonist possess significant analgesic activity. It should be investigated further as potential treatment option for painful conditions in hypertensive patients.

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“…Intraperitoneal injection of acetic acid produces pain through activation of chemosensitive nociceptors 20 or irritation of the visceral surface, which lead to the liberation of histamine, bradykinin, prostaglandins and serotonin. 24 Also, it has been noted that the level of analgesia in acetic acid-induced models is indicated by the percent reduction in the number of abdominal constrictions.…”

Section: Discussionmentioning

confidence: 99%

Peripheral and central analgesic activity evaluation of ethanolic extract of Vitex Negundo flowers in experimental animals

Maniyar

Sriraj

2017

Int J Basic Clin Pharmacol

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Background: Vitex negundo Linn (Family: Verbenaceae), locally known as ‘Nirgundi’ an important medicinal plant is a woody, aromatic shrub growing to a small tree. It commonly bears tri- or penta-foliate leaves on quadrangular branches, which give rise to bluish-purple coloured flowers in branched tomentose cymes. It has been claimed to possess analgesic activity apart from many medicinal properties. The aim of the present study was to evaluate both the peripheral and central analgesic activity of ethanolic extract of Vitex negundo flowers (EEVNF) in experimental animals.Methods: Acute toxicity test was done following the Organization of Economic Cooperation and Development guidelines. EEVNF (100mg/kg, 200mg/kg, and 400 mg/kg body weight [b.w.] p.o) was evaluated for peripheral analgesic activity by the acetic acid (0.7%) induced writhing test and central analgesic activity by the tail flick method respectively using aspirin (100mg/kg b.w. and 300mg/kg b.w.) as the standard drug.Results: EEVNF significantly decreased the number of writhing in writhing test at all the doses (p<0.001) and increased the reaction time in tail-flick method (p<0.001) at all the doses when compared to control. EEVNF in the dosage of 400mg/kg b.w. produced analgesic effects which was comparable with that of the standard drug aspirin at dose 100mg/kg b.w in writhing test and produced greater analgesic activity than that of standard drug aspirin at dose 300mg/kg b.w in tail flick method.Conclusions: EEVNF has significant peripheral and central analgesic activity.

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Analgesic activity of angiotensin antagonists

Cited by 8 publications

References 10 publications

Atorvastatin and simvastatin as analgesic agents in experimental models

Atorvastatin and simvastatin as analgesic agents in experimental models

Untitled

Peripheral and central analgesic activity evaluation of ethanolic extract of Vitex Negundo flowers in experimental animals

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