Analgesic and Anti-inflammatory Activities of Flower Extracts of Punica granatum Linn. (Punicaceae)

Abstract

Punica granatum has been used for centuries to confer health benefits in a number of inflammatory diseases. Based on its usage in Ayurvedic and Unani medicine, dietary supplements containing pomegranate extract are becoming popular for the treatment and prevention of arthritis and other inflammatory diseases. Pet-ether, dichloromethane and methanol fractions of flower part were chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal model. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the acetic acid-induced writhing test. In the acetic acid-induced writhing test in mice, pet-ether, dichloromethane and methanol fractions at 200 mg/kg doses level showed 75.77% (p<0.001), 68.56% (p<0.001), 54.64% (p<0.001) inhibition of writhing, respectively. In rat paw edema model induced by carrageenan, pet-ether, dichloromethane and methanol fractions were found to reduce significantly (p<0.001) the formation of edema at the 100 mg/kg dose level and showed 26.92% (p<0.001), 27.97%(p<0.001), 21.85%(p<0.001) inhibition respectively of edema volume at the end of 4 h. Punica granatum possesses evident analgesic and anti-inflammatory activities. The results signify the traditional uses of Punica granatum for inflammation and pain.

Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

“…The antiinflammatory and antioxidant effects of Persian Golnar were demonstrated in rats with diabetes (Bagri et al, 2009). Hepatoprotective analgesic effects in rats and anticancer effects of this plant have been reported (Lansky and Newman, 2007;Celik et al, 2009;Sarker et al, 2012). A reduction in gingival bleeding after using toothpaste containing Persian Golnar was demonstrated (Prasad and Kunnaiah, 2014).…”

Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna

“…Anti-inflammatory and antinociceptive activity of different parts of P. granatum including leaves, flowers and fruit were demonstrated in various studies [78][79][80][81][82][83][84][85]. Polyphenol-rich extract of pomegranate fruit exerted an anti-inflammatory effect in animal model by inhibiting the production of PGE 2 and NO [86].…”

Evaluations of antidepressant activity of Punica granatum peel extract in albino mice

“…Hence the present study was planned. [7][8][9][10][11][12][13][14][15][16] These phytochemical components contribute wonderful, economic and eco-friendly effects of pomegranate peel extract. 17 The antidepressant activity of Punica granatum is mentioned in the Indian system of traditional medicine, but there is a rare scientific evidence to prove its activity by Shamima et al 18 Hence, the present study is designed to evaluate the antidepressant activity of Punica granatum peel extract using animal models in mice was planned.…”