Analgesic and anti-inflammatory activities of Cnestis ferruginea Vahl ex DC (Connaraceae) methanolic root extract

Ishola, Ismail O.; Akindele, Abidemi J.; Adeyemi, Olufunmilayo O.

doi:10.1016/j.jep.2011.02.024

Cited by 59 publications

(47 citation statements)

References 32 publications

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“…In respect of the acute toxicity test, the methanol root extract of CF administered orally caused no mortality at 1 and 2 g/kg but mortality was 20, 60, and 100%, respectively, at doses of 4, 8, and 10 g/kg, as previously reported by our research team (Ishola et al, 2011). The LD 50 was estimated to be 5.22 g/kg.…”

Section: O Ishola Et Alsupporting

confidence: 76%

“…The doses of CF used in this study represent the sub-therapeutic, therapeutic, and supra-therapeutic doses, respectively, based on the modification of the protocol of Yemitan and Adeyemi (2004), Amida et al (2007), and Adeyemi et al (2010). The therapeutic dose of 400 mg/kg was the most effective dose in a previous study in our laboratory which investigated the analgesic and anti-inflammatory activities of the methanol root extract of CF (Ishola et al, 2011).…”

Section: Sub-chronic Toxicity Testmentioning

confidence: 99%

“…The acute toxicity study of the methanol root extract of CF had previously been done in our laboratory and reported (Ishola et al, 2011). In the study, groups of 5 mice each fasted for 12 h prior to the experiment were administered CF orally at doses of 1, 2, 4, 8, and 10 g/kg.…”

Section: Acute Toxicity Studymentioning

confidence: 99%

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Sub-chronic toxicity study of the methanol root extract ofCnestis ferruginea

Ishola

Akindele

Adeyemi

2012

Pharmaceutical Biology

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Section: O Ishola Et Alsupporting

confidence: 76%

Section: Sub-chronic Toxicity Testmentioning

confidence: 99%

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Sub-chronic toxicity study of the methanol root extract ofCnestis ferruginea

Ishola

Akindele

Adeyemi

2012

Pharmaceutical Biology

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“…It was reported to have significant antioxidant activity (Oke & Hamburger, 2002). Recently, we reported the antistress potential (Ishola & Ashorobi, 2007) and analgesic and anti-inflammatory properties (Ishola et al, 2011) of C. ferruginea in rodents. However, the effect of C. ferruginea on memory function and central cholinergic system has not been explored.…”

Section: Introductionmentioning

confidence: 99%

Protective effect ofCnestis ferrugineaand its active constituent on scopolamine-induced memory impairment in mice: A behavioral and biochemical study

Ishola

Tota²,

Adeyemi

et al. 2013

Pharmaceutical Biology

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Context: Cnestis ferruginea Vahl ex DC (Connaraceae) (CF) is used in traditional African medicine in the management of CNS disorders. The degeneration and dysfunction of cholinergic neurons is closely associated with the cognitive deficits of Alzheimer's disease (AD) and oxidative stress has been implicated in its pathogenesis. However, the influence of C. ferruginea on the cholinergic system and oxidative stress parameters has not been explored. Objective: The present study investigates the effect of methanol root extract of C. ferruginea and its active constituent amentoflavone (CF-2) on memory, oxidative stress and acetylcholinesterase (AChE) activity in scopolamine-induced amnesia. Materials and methods: Mice were orally treated with CF (25-200 mg/kg), CF-2 (6.25-25 mg/kg) for three days and memory impairment was induced by intraperitoneal injection of scopolamine (3 mg/kg). Memory function was evaluated by passive avoidance and Morris water maze tests. Biochemical parameters of oxidative stress and cholinergic function were estimated in brain after the completion of behavioral studies. Results: Scopolamine caused memory impairment along with increased AChE activity and oxidative stress in mice brain. Oral administration of CF and CF-2 significantly prevented scopolamine-induced memory impairment, inhibited AChE and enhanced antioxidant enzyme activity in the brain following scopolamine injection as compared to vehicle administration in scopolamine (i.p.)-treated mice that were comparable to the effect of tacrine. Discussion and conclusion: The study demonstrated that C. ferruginea and its constituent have significant protective effect against scopolamine-induced memory deficits in mice that can be attributed to their antioxidant and antiAChE activity.

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“…Cnestis ferruginea Vahl ex DC. is a shrub widely used in traditional African medicine for the treatment of various painful and infl ammatory conditions (Ishola et al 2011).…”

Section: Introductionmentioning

confidence: 99%

<i>FSA</i> contributions 21: Connaraceae

Jordaan

2013

Bothalia

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Analgesic and anti-inflammatory activities of Cnestis ferruginea Vahl ex DC (Connaraceae) methanolic root extract

Cited by 59 publications

References 32 publications

Sub-chronic toxicity study of the methanol root extract ofCnestis ferruginea

Sub-chronic toxicity study of the methanol root extract ofCnestis ferruginea

Protective effect ofCnestis ferrugineaand its active constituent on scopolamine-induced memory impairment in mice: A behavioral and biochemical study

<i>FSA</i> contributions 21: Connaraceae

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