Analgesic and anti-inflammatory activity of hydroalcoholic extract of Piper betle leaves in experimental animals

Reddy, Pooja; Gupta, Rajesh; Reddy, Srikanth

doi:10.18203/2319-2003.ijbcp20161556

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…In the study of Reddy et al [349], the analgesic and anti-inflammatory activity of a hydroalcoholic extract (70% ethanol and 30% distilled water) of P. betle leaves (HEPBL) were demonstrated. Wistar rats and Albino mice were administered different concentrations of HEPBL according to OECD guideline no.…”

Section: Biological Activities Piper Plantsmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

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Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

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Section: Biological Activities Piper Plantsmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

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“…• Terjadi efek analgesik pada mencit albino yang diinduksi hot plate dengan pemberian 100 dan 200mg/kg BB ekstrak metanol daun sirih [20] • Kandungan aktif utama: Hidroksikavikol [19] • Terjadi efek analgesik pada mencit albino yang diinduksi asam asetat dengan pemberian 100, 200, 400 mg/kgBB ekstrak metanol daun sirih [21] • Terjadi efek analgesik pada tikus albino yang diinduksi hot plate dengan pemberian 100 dan 200 mg/kgBB ekstrak aqueous daun sirih [22] • Terjadi efek analgesik pada tikus wistar yang diinduksi asam asetat dengan pemberian 100 dan 200 mg/kgBB ekstrak hidroalkohol daun sirih [23] • Terjadi efek analgesik pada tikus sprague dawley yang diinduksi hot plate dengan pemberian 100 dan 200 mg/kgBB ekstrak etanol daun sirih [24] Pengujian efektitas Piper betle sebagai analgesik dilakukan dengan metode hot plate pada penelitian alam et al [20], didapatkan hasil pemberian ekstrak metanol daun sirih 100 dan 200 mg/kgBB menunjukkan efek analgesik terhadap mencit yang signifikan (P ≤ 0,05). Ekstrak metanol daun sirih dengan dosis 100 mg/kgBB memberikan waktu respon analgesik tertinggi pada menit ke-90 selama 7 detik sedangkan pada ekstrak metanol daun sirih dengan dosis 200 mg/kgBB memberikan waktu respon analgesik tertinggi pada menit yang sama selama 12 detik.…”

Section: Hasil Dan Pembahasanunclassified

“…Efek analgesik yang dihasilkan oleh pemberian ekstrak metanol daun sirih dengan dosis 200 dan 400 mg/kgBB lebih besar dibandingkan pemberian aspirin 400mg/kgBB yang hanya mampu mengurangi geliatan mencit sebesar 67,32% saja. Penelitian Reddy et al [23] juga menggunakan metode yang sama, hasil yang didapatkan yakni pemberian ekstrak hidroalkohol daun sirih dengan dosis 100mg/kgBB mampu mengurangi geliatan tikus sebesar 76,1 % sedangkan pemberian ekstrak hidroalkohol daun sirih dengan dosis 200mg/kgBB mampu mengurangi geliatan mencit sebesar 79,3%. Kemampuan pengurangan geliatan tikus oleh ekstrak hidroalkohol daun sirih dengan dosis 100 dan 200mg/kgBB ini lebih baik dibandingkan dengan pemberian aspirin 25mg/kgBB yang hanya mampu mengurangi geliatan mencit sebesar 58,4%.…”

Section: Hasil Dan Pembahasanunclassified

Pemanfaatan Tanaman Herbal Dalam Pengobatan Nyeri Berdasarkan Kearifan Lokal Bali Usada Tiwang

Ni Kd Rintan Listiani Ekayanti

2023

WSNF

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Nyeri merupakan rasa tidak nyaman yang umumnya merupakan tanda adanya gangguan fungsi organ atau kerusakan pada organ tubuh seperti peradangan, infeksi kuman, atau kejang otot. Analgesik sintetik merupakan terapi yang paling umum digunakan untuk meredakan nyeri. Namun, penggunaan analgesik menyebabkan berbagai efek samping salah satunya kerusakan gastrointestinal. Bali, dengan keunikan budayanya, memiliki cara pengobatan nyeri secara tradisional yang bersumber dari Usada Tiwang. Penelitian ini bertujuan untuk meninjau efektivitas dan mekanisme pengobatan nyeri secara tradisional menggunakan tanaman herbal berupa rimpang kunyit (Curcuma longa.) dan daun sirih (Piper betle.) yang tertulis dalam Usada Tiwang sehingga dapat dimanfaatkan sebagai pengobatan nyeri alternatif. Metode yang digunakan dalam ulasan artikel ini yakni studi literatur dengan kata kunci analgesik, usada tiwang, Curcuma longa, dan Piper betle dari berbagai penelitian terbaru pada jurnal nasional dan internasional yang telah diterbitkan. Berbagai penelitian melaporkan rimpang kunyit (Curcuma longa.) mengandung senyawa kurkumin yang terbukti mampu mengurangi nyeri dengan mekanisme penghambatan metabolisme asam arakidonat. Sedangkan daun sirih (Piper betle.) mengandung senyawa hidroksikavikol yang dapat menekan produksi siklooksigenase dan mengandung senyawa saponin yang dapat menghambat sintesis prostaglandin sehingga mampu memberikan efek anagesik. Dari studi pustaka ini, dapat disimpulkan bahwa terdapat kesesuaian efek farmakologis dengan efek empiris yang terdapat dalam Usada Tiwang serta telah diketahui mekanisme aktivitas rimpang kunyit (Curcuma longa.) dan daun sirih (Piper betle.) sebagai analgesik sehingga nantinya dapat dijadikan sebagai produk pengobatan alternatif untuk meredakan nyeri.

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“…The analgesic and anti-inflammatory activity of P.betle can be attributed to the presence of phytochemical compounds, namely flavonoids, tannins, phenols and glycosides. [30]…”

Section: Piper Betel Analgesic and Anti-inflammatory Activitymentioning

confidence: 99%

An Exploratory Review of Pharmcological Activities of Notchi Kudineer- A Siddha Herbal Decoction Used in Covid-19

Ragaroobine

Ragavanee

Adaikalam

et al. 2021

Int J Ayu Pharm Res

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COVID-19 Caused by the novel corona virus (SARS-CoV-2), which has already pushed the entire global community to change their priorities towards finding a suitable anti-viral medicine and a vaccine. While most of the countries have started to prescribe vaccines, which show varied levels of efficacy, finding an effective anti-viral medicine against the virus is still in the early stages despite full-fledged research activities at global level. Many countries particularly those having a rich traditional health science background like India and China started to recommend medicines belonging to local health traditions. The public utilization of those medicines also yielded good results in terms of prevention of the viral infection, reducing the severity of disease or/and reducing the number of days required to recover from the disease as perceived and reported by the patients and doctors. In Tamil Nadu, there are more than 80 million populations. Siddha medicine is the most widely used system of traditional medicine. ‘Suram’ is the Tamil word equivalent to the term ‘fever’. Kabasuram (Also known as Aiya suram) is one among the 64 types of fevers mentioned in Siddha symptoms of which are identical to those of COVID-19. “Notchi kudineer”– a Siddha herbal formulation is being used since many centuries for fever and respiratory disorders with remarkable success. This review article attempts to explore the pharmacological evidence in support of the therapeutic usage of “Notchi kudineer” hence justifying its usage in respiratory related illnesses having fever as a main symptom like the current pandemic of COVID-19.

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Analgesic and anti-inflammatory activity of hydroalcoholic extract of Piper betle leaves in experimental animals

Cited by 6 publications

References 10 publications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Pemanfaatan Tanaman Herbal Dalam Pengobatan Nyeri Berdasarkan Kearifan Lokal Bali Usada Tiwang

An Exploratory Review of Pharmcological Activities of Notchi Kudineer- A Siddha Herbal Decoction Used in Covid-19

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