Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice

Ahmad, Naseem; Waheed, Akbar; Farman, Muhammad; Qayyum, Aisha

doi:10.1016/j.jep.2010.03.017

Cited by 84 publications

(68 citation statements)

References 13 publications

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“…Furthermore, other beneficial effects of pistachios include antiseptic, antimicrobial, antidiabetic, anti-inflammatory, anti-nociceptive, anti-hepatotoxic, and anticancer effects (25). Because of their beneficial ingredients such as antioxidants, flavonoids, vitamins, and minerals, and strong anti-inflammatory properties, pistachios are used to treat central nervous system diseases such as Alzheimer's disease and epilepsy (21,22). The beneficial effect of the pistachio on the nervous system may be due to its compositions.…”

Section: Discussionmentioning

confidence: 99%

“…Free radicals play an important role in nerve damage caused by stroke and Alzheimer's disease (30). Hence, pistachios may be used as a beneficial factor for the treatment of these diseases and improvement in learning and memory (21,22,28). Various vitamins, particularly vitamins B1, B2, B6, E, and C, in addition to improving physical strength, increase nervous power, and therefore, are used for the treatment of central nervous system diseases (31).…”

Section: Discussionmentioning

confidence: 99%

“…Some of these beneficial effects may be related to the antioxidants naturally present in pistachios, since pistachio consumption has been shown to reduce oxidative stress markers in healthy subjects (10). Recently, pistachio has been used to treat central nervous system diseases because of its beneficial compounds such as antioxidants and phytochemicals and strong anti-inflammatory properties (21,22). Its use has been recommended in Alzheimer's disease and epilepsy (21).…”

Section: Introductionmentioning

confidence: 99%

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Effect of the hydroalcoholic extract of pistachio on avoidance learning in male Wistar rats

Salari

Baloochi

Ali

et al. 2014

JOHE

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Received: December 2015, Accepted: January 2016Background: Pistachio is a plant that has long been cultivated in different parts of Iran. Pistachios are very nutritious and contain vitamins E and B, flavonoids, antioxidants, and carotenoids. Since the pistachio is effective in the treatment of some neurological disorders and is indigenous to Iran and considering the substantial use of this nut, it is necessary to investigate its effects on cognitive functions of the brain. This study aimed to investigate the effect of the hydroalcoholic extract of the pistachio on avoidance learning in rats. Materials and Methods: In this experimental study, 40 male Wistar rats (200-250 g body weight and 2-3 months of age) were divided into 4 groups. Dimethyl sulfoxide (DMSO) 2.5% (vehicle) and hydroalcoholic extract of the pistachio (10, 50, and 100 mg/kg/day) were administered by gavage for 14 days. Avoidance learning test was performed using the shuttle box. Results:The results of this study indicated a significant increase in the latency to enter the dark room in the groups receiving different doses of pistachio extract compared to vehicle treated group. Moreover, in the treated groups, time spent in the dark room was decreased compared to the vehicle group. The comparison of different doses of pistachio extract demonstrated that 100 mg/kg was more effective than 10 and 50 mg/kg of the extract. Conclusions:The results of this study indicated that treatment of rats with pistachio extract, which is rich in vitamins, flavonoids, and antioxidant compounds, can improve learning and memory.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of the hydroalcoholic extract of pistachio on avoidance learning in male Wistar rats

Salari

Baloochi

Ali

et al. 2014

JOHE

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“…13 Galls of Pistacia integerrima are used to treat hepatitis and liver disorders in Pakistan. 14,15 They are also known for their use in diabetes, pain, fever and inflammatory conditions. 16 Chemical investigation of Pistacia integerrima leaf revealed that this interesting plant contains carotenoids, triterpenoids, catechins and flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Isolation Studies From Stem Extract of Pistacia Integerrima Stew. Ex Brand

Bibi

Qayyum

Nisa

et al. 2016

J. Chil. Chem. Soc.

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Plants have been source of fantastic natural compounds that range in complexity. Chemical studies on traditional medicinal plants have led to discovery of potent bioactive components. Pistacia integerrima belonging to family Anacardiaceae has been traditionally effective for rheumatic pain, analgesic and antipyretic effects and used in treatment of coughs, phthisis, asthma and dysentery. Natural products have served as basis for compounds to be utilized in drug discovery. Stem extract of Pistacia integerrima was investigated with the aim to find some novel components that can later be used as drugs or active pharmaceutical intermediates. Plant material was collected from Margalla Hills Islamabad, shade dried and subjected to cold maceration technique for extraction. Crude extract was partitioned into different fractions on polarity basis. Repeated normal and reverse phase column chromatography of ethyl acetate fraction supported by Thin Layer Chromatography have led to the isolation of pure single compound. Isolated compound was further analyzed towards structural elucidation using LC-MS, IR and NMR spectroscopy. Present finding will be a useful and novel addition in already known chemical components from Pistacia integerrima.

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“…Due to its unique shape and diverse efficacy, mastic has been called "the tear drop of Christ". Mastic extracts have been reported to show antitumor activity (including the enhancement of anticancer drugs' action and induction of apoptosis via oxidative stress) (1,2), antioxidant activity (that correlated with phenolic and flavonoid contents) (3)(4)(5)(6)(7)(8), antibacterial activity (9)(10)(11), modulating activity of drug-metabolizing enzymes (12,13) and antiviral activity (14)(15)(16)(17). However, most previous investigators did not describe the chemotherapeutic index of these activities (that is the ratio of the biological activity to cytoxicity), even though there is a cautionary note that mastic extracts showed potent cytotoxicity (18).…”

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Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices

Suzuki

Sakagami

Amano

et al. 2017

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Abstract. Background: Most previous mastic investigatorshave not Mastic is the extract of sap from Pistacia lentiscus, grown only in the Chios island of Greece. Due to its unique shape and diverse efficacy, mastic has been called "the tear drop of Christ". Mastic extracts have been reported to show antitumor activity (including the enhancement of anticancer drugs' action and induction of apoptosis via oxidative stress) (1, 2), antioxidant activity (that correlated with phenolic and flavonoid contents) (3-8), antibacterial activity (9-11), modulating activity of drug-metabolizing enzymes (12, 13) and antiviral activity (14-17). However, most previous investigators did not describe the chemotherapeutic index of these activities (that is the ratio of the biological activity to cytoxicity), even though there is a cautionary note that mastic extracts showed potent cytotoxicity (18).In the present study, we separated the crude mastic extract into 5 different fractions using organic solvents and, then, reexamined the biological activity of unfractionated and fractioned extracts, based on chemotherapeutic indexes. Materials and MethodsMaterials. The following chemicals and reagents were obtained from the indicated companies: Dulbecco's modified Eagle's medium (DMEM) (Gibco BRL, Grand Island, NY, USA); fetal bovine serum (FBS), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), RPMI 1640 medium, doxorubicin, azidothymidine (AZT), 2',3'-dideoxycytidine (ddC) (Sigma-Aldrich Inc., St. Louis, MO, USA); dimethyl sulfoxide (DMSO) (Wako Pure Chemical Ind., Ltd., Osaka, Japan), curdlan sulfate (CRDS) (79 kDa; Ajinomoto Co. Inc., Tokyo, Japan). Culture plastic dishes and plates (96-well) were 591 This article is freely accessible online.

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Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice

Cited by 84 publications

References 13 publications

Effect of the hydroalcoholic extract of pistachio on avoidance learning in male Wistar rats

Effect of the hydroalcoholic extract of pistachio on avoidance learning in male Wistar rats

Isolation Studies From Stem Extract of Pistacia Integerrima Stew. Ex Brand

Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices

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