Analgesic and anti-inflammatory effects of resveratrol in rat models of pain: Any role in clinical pain management?

Nwasor, Elizabeth O Ogboli; Isa, Ahmed Sherif; Dingwoke, Emeka John; Umar, Abdullahi Hussein

doi:10.4103/archms.archms_54_17

Cited by 3 publications

(2 citation statements)

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“…It has been shown that RES possesses numerous therapeutic effects, such as antioxidant [68][69][70][71], anti-inflammatory [72][73][74][75], cardioprotective [76][77][78][79], or analgesic effects [80][81][82], and has an impact on diabetes and obesity [83][84][85]. RES has been further studied for its increasing relevance in various neurological disorders, such as Alzheimer's [86][87][88], Parkinson's [89,90], and other neurodegenerative diseases [91,92], as well as brain tumors [93][94][95].…”

Section: Biological Effects Of Resveratrolmentioning

confidence: 99%

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

et al. 2020

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Despite intensive research, malignant brain tumors are among the most difficult to treat due to high resistance to conventional therapeutic approaches. High-grade malignant gliomas, including glioblastoma and anaplastic astrocytoma, are among the most devastating and rapidly growing cancers. Despite the ability of standard treatment agents to achieve therapeutic concentrations in the brain, malignant gliomas are often resistant to alkylating agents. Resveratrol is a plant polyphenol occurring in nuts, berries, grapes, and red wine. Resveratrol crosses the blood‒brain barrier and may influence the central nervous system. Moreover, it influences the enzyme isocitrate dehydrogenase and, more importantly, the resistance to standard treatment via various mechanisms, such as O6-methylguanine methyltransferase. This review summarizes the anticancer effects of resveratrol in various types of brain cancer. Several in vitro and in vivo studies have presented promising results; however, further clinical research is necessary to prove the therapeutic efficacy of resveratrol in brain cancer treatment.

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Section: Biological Effects Of Resveratrolmentioning

confidence: 99%

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

et al. 2020

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“…It has been demonstrated that resveratrol has a pain controlling and antiinflammatory effects in many pre-clinical and clinical studies (32 33,23,34) . The suggested mechanism of resveratrol in amelioration of pain was elucidated by reduction in the production of prostaglandins from arachidonic acid as a result of potential inhibition of cyclooxygenase -2 (COX-2) isoform, an enzyme that is in charge of inflammation and pain (35,36) . Furthermore, in animal model with chronic constriction injury, resveratrol was observed to reduce neuropathic pain after sciatic nerve injury and it lessen the mechanical allodynia and thermal hyperalgesic sensation, the suggested mechanism was through increases interleukin-4 (IL-4) receptormediated anti-inflammatory actions (37) .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Resveratrol Supplementation on the Quality of Life of Diabetic Patients with Neuropathy: Small Randomized Clinical Trial

M. Amin,

Marouf,

Namiq

2023

IJPS

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The diabetic neuropathy complication exerts a considerable decline in the level of patient’s well-being. The main approaches to hamper the progression of diabetic complications and improve patient’s life quality are controlling the glycemic levels and amelioration of the hyperglycemia-induced neuroinflammation, oxidative stress and pain. Supplementation of appropriate anti-inflammatory and anti-oxidants such as resveratrol may therefore be effective in the management of diabetic complications. The aim of this trial was to assess resveratrol’s impact on improving life quality of patients with the neuropathic complication of diabetes. Sixty-one patients with diabetic neuropathy were recruited in this double-blinded placebo-controlled trial. Patients were randomized into the resveratrol (n=31) group; who received a 500mg resveratrol capsule once daily concomitantly with the conventional hypoglycemic agents for three months, and the placebo (n=30) group. From each group 25 patients completed the study. The quality of life (QoL) of the patients was estimated utilizing RAND 36-item survey questionnaire. Fasting blood glucose levels were analyzed at the baseline and on the last day of the 3rd month. There was a significant decrement (p< 0.001) in the fasting serum glucose level of the patients supplemented with resveratrol at the end of the 3rd month, in comparison with the patient using the placebo. There was also a significant improvement in patient’s severity of pain (p<0.001) as shown in the bodily pain score of the RAND 36 scale and a remarkable (p < 0.05) improvement in physical functioning, physical health, social functioning, emotional well-being, energy/fatigue, and health change subscales of the questionnaire. The study concluded that resveratrol is the polyphenol that has a positive effect on reducing pain associated with diabetic neuropathy and improving the overall QoL of the patient.

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Medicinal Plants for Glioblastoma Treatment

Datta

Luthra

Bharadvaja

2022

ACAMC

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: Glioblastoma, an aggressive brain cancer, demonstrates the least life expectancy among all brain cancers. Because of the regulation of diverse signaling pathways in cancers, the chemotherapeutic approaches used to suppress their multiplication and spreading are restricted. Sensitivity towards chemotherapeutic agents has developed because of the pathological and drug-evading abilities of these diverse mechanisms. As a result, the identification and exploration of strategies or treatments, which can overcome such refractory obstacles to improve glioblastoma response to treatment as well as recovery, is essential. Medicinal herbs contain a wide variety of bioactive compounds, which could trigger aggressive brain cancers, regulate their anti-cancer mechanisms and immune responses to assist in cancer elimination, and cause cell death. Numerous tumor-causing proteins, which facilitate invasion as well as metastasis of cancer, tolerance of chemotherapies, and angiogenesis, are also inhibited by these phytochemicals. Such herbs remain valuable for glioblastoma prevention and its incidence by effectively being used as anti-glioma therapies. This review thus presents the latest findings on medicinal plants using which the extracts or bioactive components are being used against glioblastoma, their mechanism of functioning, pharmacological description as well as recent clinical studies conducted on them.

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Analgesic and anti-inflammatory effects of resveratrol in rat models of pain: Any role in clinical pain management?

Cited by 3 publications

References 1 publication

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

The Effects of Resveratrol Supplementation on the Quality of Life of Diabetic Patients with Neuropathy: Small Randomized Clinical Trial

Medicinal Plants for Glioblastoma Treatment

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