Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica

Wu, Yin; Wang, Tian-Shan; Yin, Fan; Cai, Baochang

doi:10.1016/s0378-8741(03)00224-1

Cited by 180 publications

(106 citation statements)

References 17 publications

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“…Cai et al (1996) revealed that crude alkaloid fractions of nux-vomica have anti-nociceptive effects, and detoxification processes increase this biological activity (21). Moreover, Yin et al (2003) have suggested that brucine and brucine N-oxide have pain modulation and anti-inflammatory effects through both the central and peripheral mechanisms (22). Within the same line of thought, showed, via animal studies, that the detoxification process does not reduce the antiinflammatory effects (23).…”

Section: Discussionmentioning

confidence: 99%

Different Traditional Methods of Nux-Vomica Detoxification Have Therapeutic Rationales

Kashani¹,

Hatami²,

Safaei³

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Strychnos nux-vomica is a well-known poisonous plant, which is detoxified by different methods in traditional medicines. Most of traditional medical schools introduce general detoxification methods that can be substituted with each other. The main goal of these methods is to reduce the total alkaloids. In contrast, Iranian traditional medicine (ITM) has suggested three non-general, nonsubstitutable methods, which have specific medical indications: 1, boiling the seeds in water until all the water evaporates (prescribed for diarrhea treatment); 2, soaking the seeds in cow's milk for seven days, followed by peeling the seeds (for addiction treatment); 3, soaking the seeds in cow's milk for seven days, peeling the seeds, and boiling them in milk (for arthralgia and paralysis). Objectives: The aim of this study was to clarify the therapeutic rationale for each method. Materials and Methods: Nux-vomica seeds were divided into four groups: three groups were detoxified via ITM methods, and one group was kept intact as a control. All samples were powdered, and their alkaloids and total phenolic compounds were determined by HPLC and spectrophotometery, respectively. Results: The first ITM method reduced the strychnine level from 1.083 to 0.577 and brucine from 0.739 to 0.361. For the second and third ITM methods, the levels of strychnine reached 0.838 and 0.812, and the levels of brucine reached 0.522 and 0.568, respectively. Conclusions: Clinically, these results are logical because the required dose of alkaloids for treatment of diarrhea is lesser than the needed doses to treat addiction, arthralgia, and paralysis.

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Section: Discussionmentioning

confidence: 99%

Different Traditional Methods of Nux-Vomica Detoxification Have Therapeutic Rationales

Kashani¹,

Hatami²,

Safaei³

et al. 2016

Jundishapur J Nat Pharm Prod

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“…Colchicum luteum which has been reported to have anti-arthritic activity due to its modulatory effect on the expression of pro-inflammatory cytokine in the synovium, Vitex negundo and Strychnos nuxvomica also have been reported to have anti-inflammatory and antiarthritic activity. [12][13][14] According to Ayurveda, Maharasnadi Kwath present in formulation also reported to be used to treat muscular and joint pains. Therefore, protective effect of RC may be attributed to presence of different plants having anti-inflammatory activity and maharasnadi kwath.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of anti-inflammatory potential of ayurvedic formulation Rheumacure in animal model of rheumatoid arthritis

Patel¹,

Desai

Shah³

et al. 2016

Int J Basic Clin Pharmacol

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“…Plasma PK study 1.5-2.0 mL blood samples were collected from the abdominal aorta at 0. 5,2,4,8,12,14,16,18,20,22,24, 28 and 36 hours after intravenous injection of brucine phosphate buffered saline solution or LB suspension, to study the sustained-release properties of the liposome delivery method.…”

Section: Skin Pk Studymentioning

confidence: 99%

“…2 Its main pharmacodynamic actions are to relieve pain, reduce swelling, and promote circulation. Unfortunately, the potential use of brucine is severely limited due to its high incidence of side effects, including violent convulsions and even lethal poisoning.…”

Section: Introductionmentioning

confidence: 99%

Study of pharmacokinetics and tissue distribution of liposomal brucine for dermal administration

Yang

Chu²,

Zhu³

et al. 2011

IJN

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Objective: To evaluate the pharmacokinetics and tissue distribution of liposomal brucine (LB) for dermal application. Methods: Pharmacokinetics and tissue distribution were studied by in vivo animal testing. High performance liquid chromatography (HPLC) was used to detect the concentration of brucine in rats' skin, plasma and various tissues. Results: After dermal administration, LB was absorbed rapidly in the skin and could be detected after 0.5 hours. After 36 hours, levels were too low to be detected. In plasma, levels were also too low to be detected after 36 hours. The concentration of LB reached 50% of the maximum in all tissues except the brain, peaking after 1.5 hours but still detectable after 12 hours. Conclusion: The concentration of LB was high in skin at the application site. LB was quickly absorbed into tissues through the blood circulation and widely distributed throughout the whole body. There was no obvious toxicity and LB did not readily accumulate in tissues and organs. It showed local potency but low overall systemic toxicity.

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Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica

Cited by 180 publications

References 17 publications

Different Traditional Methods of Nux-Vomica Detoxification Have Therapeutic Rationales

Different Traditional Methods of Nux-Vomica Detoxification Have Therapeutic Rationales

Evaluation of anti-inflammatory potential of ayurvedic formulation Rheumacure in animal model of rheumatoid arthritis

Study of pharmacokinetics and tissue distribution of liposomal brucine for dermal administration

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