Analgesic and antidepressant activities of Brassica rapa subspecies chinensis (L.) Hanelt on Swiss-albino mice model

Abstract

Bangladesh being a subtropical country provides varieties of herbs and vegetables. Brassica is a broad genus available in Bangladesh and it encompasses a lot of nutritive herbs. Among these, Brassica rapa subspecies chinensis (L.) Hanelt (Family-Brassicaceae) is popular in many parts of the world. In the quest of medicinal property, this plant was investigated here for observing analgesic and antidepressant activities in Swiss-albino mice model. The herb was extracted well with methanol and then assayed by acetic acid-induced writhing and tail immersion methods for analgesic action. Besides, thiopental sodium induced sleeping time test, tail suspension test and forced swim test were conducted for the evaluation of its antidepressant activity. The plant extract was orally administered to the mice at 200 and 400 mg/kg body weight and it exhibited significant analgesic and antidepressant activities in compare to the controlled groups. This is the first time comprehensive report for analgesic and antidepressant activities of this plant.

Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane

“…italica sprouts might involve opioid mechanisms (Baenas et al 2017 ). Our results support central analgesic-like effects in other Brassica species since it was reported that an extract of Brassica rapa subspecies chinensis extract increased withdrawal latency in the tail immersion test (Rahman et al 2015 ). Preliminary studies have already reported the analgesic-like response of the pure compound SFN in neuropathic (Wang and Wang 2017 ) and abdominal (Guadarrama-Enriquez et al 2018 ) pain, and for the sprouts (Baenas et al 2017 ), which effects were avoided in the presence of an opioid antagonist reinforcing the involvement of this inhibitory neurotransmission.…”

Antimicrobial Activity of Brassica rapa L. Flowers Extract on Gastrointestinal Tract Infections and Antiulcer Potential Against Indomethacin-Induced Gastric Ulcer in Rats Supported by Metabolomics Profiling

“…The utilized doses of BRFE were based on previous biological investigations for the same species using different plant organs. 29 , 30 …”

Analgesic, Anti-diarrheal, Anti-depressant, Membrane Stabilizing and Cytotoxic Activities of Bridelia verrucosa Haines

“…Anti-depressant assay: The crude methanolic extract of B. verrucosa was subjected for the evaluation of antidepressant assay through phenobarbitone-Na induced sleeping time test (Rahman et al, 2015). Here, the test groups were orally administered with test samples prepared with normal saline water and Tween-80 at doses of 200and 400-mg/kg b.w., while the positive control group was treated with diazepam (1 mg/kg b.w.)…”