Analgesic and antiinflammatory activities of vernonioside B2 from <i>Vernonia condensata</i>

Valverde, Alessandra L.; Cardoso, G. L. C.; Pereira, Nuno; Silva, A. J. R.; Kuster, Ricardo Machado

doi:10.1002/ptr.733

Cited by 24 publications

(14 citation statements)

References 9 publications

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“…It is thought that triterpenes are responsible for the antiplasmodial activity of Vernonia brasiliana (Alves et al, 1997). Lastly, some Vernonia have antipyretic, analgesic, anti-inflammatory (Valverde et al, 2001;Iwalewa et al, 2003;Mazumder et al, 2003;Cioffi et al, 2004) and cytotoxic properties (Koul et al, 2003).…”

Section: Resultsmentioning

confidence: 99%

In vitro antiplasmodial activity of 18 plants used in Congo Brazzaville traditional medicine

Mbatchi

M’Batchi

Banzouzi

et al. 2006

Journal of Ethnopharmacology

103

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Section: Resultsmentioning

confidence: 99%

In vitro antiplasmodial activity of 18 plants used in Congo Brazzaville traditional medicine

Mbatchi

M’Batchi

Banzouzi

et al. 2006

Journal of Ethnopharmacology

103

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“…A variety of in vitro and in vivo experiments have shown that flavonoids, tannins, triterpenoids and other secondary plant metabolites possess analgesic and anti-inflammatory properties [23–25]. Vernonioside B2, for example, identified in this plant, may contribute to the observed anti-inflammatory and antinociceptive effects of V. condensata [20]. …”

Section: Resultsmentioning

confidence: 99%

“…Analgesic, anti-inflammatory and antiulcerogenic activities of V. condensata , as well as toxicity have been investigated [18–21]. In these studies, vernonioside B2 demonstrated antinociceptive and anti-inflammatory effect [20]. Furthermore, constituents such as saponins, tannins, alkaloids, phenolic compounds and flavonoids were detected in the extracts from V. condensata [21].…”

Section: Introductionmentioning

confidence: 99%

New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves

Silva

Temponi

Fernandes

et al. 2011

IJMS

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The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100 (51.00 ± 3.00), 200 (42.00 ± 2.98) and 400 mg/kg (39.00 ± 4.00). In formalin tests, a significant reduction in the licking time (p < 0.01) was observed in the first phase by 25.14 (200 mg/kg = 51.50 ± 4.44) and 31.15% (400 mg/kg = 48.00 ± 4.37). The doses of 100 (43.37 ± 5.15), 200 (34.62 ± 4.16) and 400 mg/kg (28.37 ± 3.98) inhibited (p < 0.001) the second phase. After 60 and 90 min of treatment, a dose of 400 mg/kg (10.13 ± 0.39 and 11.14 ± 1.33, respectively) increased the latency time. Doses of 200 and 400 mg/kg potentiated the sleeping time induced by diazepam, pentobarbital and meprobamate. The extracts (100, 200 and 400 mg/kg) showed anti-inflammatory effects by a decrease in paw edema. The extracts also reduced the exudate volume at the doses of 200 and 400 mg/kg. The leukocyte migration had significant effect (p < 0.001) at doses of 100, 200 and 400 mg/kg. The completion of additional experiments in the investigation of the antinociceptive and anti-inflammatory activities of V. condensata allowed a better understanding of the central and peripheral mechanisms involved.

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“…(Miranda et al, 2000) e cicatrizante (Villegas et al, 1997) (Arteel et al, 2000;Abbey et al, 2008) 39 Vernonia condensata Baker. (Asteraceae) -E.Rodrigues 63 boldo inflamação folha/decocto Atividades antiinflamatória e analgésica (Frutuoso et al, 1994;Valverde et al, 2001) 40 Zingiber officinale Roscoe (Zingiberaceae) -E.Rodrigues 90 mangarataia reumatismo tubérculo/tintura Atividade antiinflamatória (Aimbire et al, 2007) 41 …”

Section: Discussionunclassified

Perfil farmacológico e fitoquímico de plantas indicadas pelos caboclos do Parque Nacional do Jaú (AM) como potenciais analgésicas: parte I

Rodrigues¹,

Duarte-Almeida²,

Pires³

2010

Rev. bras. farmacogn.

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RESUMO: Muitos estudos de plantas medicinais baseiam-se em informações etnofarmacológicas, na intenção de encurtar o tempo e diminuir os recursos financeiros no desenvolvimento de novas drogas. O presente trabalho teve como objetivo realizar estudos de farmacologia pré-clínica e fitoquímica com três extratos vegetais, obtidos de duas das 42 plantas com potenciais efeitos analgésico e/ou antiinflamatório, indicadas pelos moradores do Parque Nacional do Jaú, AM. Os extratos hidroalcoólicos foram submetidos à caracterização fitoquímica por meio de cromatografia em camada delgada (CCD). Os testes de farmacologia pré-clínica empregados foram: screening inicial, rota rod, atividade motora, placa quente, tail flick e contorções abdominais, nas doses de 300 e 500 mg/kg. Os três extratos foram obtidos a partir das cascas da cumandá: Campsiandra comosa Benth., Fabaceae (EHCC) e das folhas (EHSF) e cascas (EHSC) da sucuuba: Himatanthus sucuuba (Spruce ex Müll. Arg.) Woodson, Apocynaceae. As análises fitoquímicas revelaram a presença de flavonóides, taninos, iridóides e triterpenos nos diferentes extratos; enquanto os alcalóides e cumarinas não foram detectados. A investigação farmacológica demonstrou atividade analgésica discreta apenas no teste de contorções abdominais para os extratos EHSF e EHCC; nenhuma alteração foi observada no aparelho de rota rod e de modo geral, observou-se diminuição da atividade motora em todos os extratos nas diferentes doses testadas. Diferentes extratos destas plantas estão sendo testados em outros modelos, pelo mesmo grupo de trabalho, a fim de aprofundar os conhecimentos acerca do perfil farmacológico destas espécies.Unitermos: Plantas medicinais, etnofarmacologia, floresta Amazônica, analgesia, inflamação, caboclos.ABSTRACT: "Phytochemical and pharmacological profile of plants indicated by caboclos of Jaú National Park (AM) as potential analgesic. Part I." This work aimed to study the pre-clinical pharmacology and phytochemistry of three plant extracts, obtained from two of the 42 plants with potential analgesic and / or anti-inflammatory, indicated by the residents of the National Park of Jaú, AM. The hydroalcoholic extracts were subjected to phytochemical characterization by thin-layer chromatography (TLC). Tests for pre-clinical pharmacology employed were: initial screening, rota rod, motor activity, hot plate, tail flick and abdominal contortions at doses of 300 and 500 mg / kg. The three extracts were obtained from the bark of cumandá: Campsiandra comosa Benth., Fabaceae (EHCC) and leaves (EHSF) and bark (EHSC) of sucuuba: Himatanthus sucuuba (Spruce ex Müll. Arg.) Woodson, Apocynaceae. The phytochemical analysis revealed the presence of flavonoids, tannins, triterpenes and iridoids in different extracts, while the alkaloids and coumarins were not detected. Research has shown pharmacological activity for EHSF and EHCC extracts, only in the mild analgesic test for abdominal contortions, while no change was observed in the rota rod; and in general, there was decrease in motor activity i...

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Analgesic and antiinflammatory activities of vernonioside B2 from Vernonia condensata

Cited by 24 publications

References 9 publications

In vitro antiplasmodial activity of 18 plants used in Congo Brazzaville traditional medicine

In vitro antiplasmodial activity of 18 plants used in Congo Brazzaville traditional medicine

New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves

Perfil farmacológico e fitoquímico de plantas indicadas pelos caboclos do Parque Nacional do Jaú (AM) como potenciais analgésicas: parte I

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