Analgesic and Antiinflammatory Activity of Kaur‐16‐en‐19‐oic acid from <i>Annona reticulata</i> L. Bark

Chavan, Machindra J.; Kolhe, Dinesh R.; Wakte, Pravin; Shinde, Devanand B.

doi:10.1002/ptr.3544

Cited by 33 publications

(15 citation statements)

References 18 publications

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“…We also hypothesized that treatment with the plant fractions also protects all the other major nerves from oxidative damage that affected in DNP condition. Previous reports on antioxidant and anti-inflammatory potential A. reticulata and Z. jujuba further strengthen the present study (Chavan et al, 2012a,b; Kandimalla et al, 2016a,e). Where, both plant bioactive fraction shows protection against DNP through reducing oxidative stress and inflammatory cytokines.…”

Section: Discussionsupporting

confidence: 91%

Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

Kandimalla

Dash²,

Kalita

et al. 2017

Front. Cell. Neurosci.

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The present study explains the neuroprotective ability of bioactive fractions of Annona reticulata bark (ARB) and Ziziphus jujuba root bark (ZJ) along with insulin against diabetic neuropathy. By using different solvents of increasing polarity ARB and ZJ were undergone for bioactive guided fractionation. The neuroprotective ability of the all the plant fractions were tested against H2O2 induced toxicity in SHSY5Y neuroblastoma cell lines and DRG neuronal cells. Among all the fractions tested, the methanol extract of ARB and ZJ (ARBME and ZJME) and its water fractions (ARBWF and ZJWF) exhibited significant neuroprotection against H2O2 induced toxicity in SHSY5Y cells and DRG neuronal cells. Further both the active fractions were tested against streptozotocin (55 mg/kg i.p.) induced diabetic neuropathy in male Wistar rats. Body weight changes, blood glucose levels and pain threshold through hot plate, tail immersion, cold plate and Randall-Sillitto methods were measured throughout the study at weekly interval. After completion of the drug treatment period, all the animals were sacrificed to measure the sciatic nerve lipid peroxidation, antioxidative enzyme levels (SOD, catalase, and GSH) and cytokine levels (IL-1β, IL-6, IL-10, TNF-α, iNOS, and NFκB) through ELISA and western blotting analysis. Results of this study explain that ARBME, ZJME, ARBWF, and ZJWF along with insulin potentially attenuate the thermal, mechanical hyperalgesia and cold allodynia in diabetic neuropathic rats, where insulin treatment alone failed to diminish the same. Reduction of sciatic nerve oxidative stress, NF-κB and iNOS mediated inflammatory cascade and normalization of abnormal cytokine release confirms the possible mechanism of action. The present study confirms the neuroprotective ability of ARB and ZJ against painful diabetic neuropathy through inhibiting oxidative stress and NF-κB inflammatory cascade.

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Section: Discussionsupporting

confidence: 91%

Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

Kandimalla

Dash²,

Kalita

et al. 2017

Front. Cell. Neurosci.

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“…considered to be supraspinally integrated responses (Chapman et al 1985;Chavan et al 2012). Crude extract and its polar fractions were shown to possess a significant analgesic effect on acetic acid inducing writhing test when compared to the control group and this in a dosedependent manner.…”

Section: Discussionmentioning

confidence: 99%

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Lajili

Deghrigue

Amor

et al. 2016

Pharmaceutical Biology

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Context: Red algae have been recognized as a rich natural source of compounds possessing interesting biological and pharmacological activities. Objective: This work investigates anti-inflammatory, analgesic and gastroprotective activities of MeOH/ CH 2 Cl 2 crude extract and its fractions F1 (50% MeOH) and F2 (80% MeOH) from the whole alga plant Laurencia obtusa Hudson (Rhodomelaceae). Materials and methods: Anti-inflammatory activity was evaluated in vitro using cytometric bead array (CBA) technology to follow up the secretion of tumour necrosis factor alpha (TNF-a) in lipopolysaccharide activated THP-1 monocytic cells at doses of 10-250 lg/mL and in vivo using carrageenan-induced paw oedema in Wistar rats at doses of 25, 50, 100 and 200 mg/kg. Crude extract and fractions were tested at the doses of 25, 50, 100 and 200 mg/kg for peripheral and central analgesic activity by acetic acid-induced writhing test and hot-plate method, respectively, in Swiss albino mice. Gastroprotective activity was evaluated using HCl/ethanol-induced gastric ulcer test in rats at doses of 25, 50, 100 and 200 mg/kg. Results: Crude extract, F1 and F2 showed an interesting inhibition of TNF-a secretion with IC 50 values of 25, 52 and 24 lg/mL, respectively, and a significant anti-inflammatory activity in vivo (p < 0.01), 3 h after carrageenan injection, the oedema inhibition was 55.37%, 52.18% and 62.86%, respectively, at the dose of 100 mg/kg. Furthermore, they showed a significant peripheral analgesic activity with 53.79%, 55.92% and 57.37% (p < 0.01) of writhing inhibition, respectively. However, no significant activity was found in the hotplate test. An interesting gastroprotective effect was observed with crude extract and its fractions F1 and F2 with a gastric ulcer inhibition of 65.48%, 77.42% and 81.29%, respectively, at the dose of 50 mg/kg. Discussion and conclusion: These results suggest that L. obtusa might be used as a potential source of natural anti-inflammatory and analgesic agents with gastroprotective effect. ARTICLE HISTORY

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“…St.-Hil., and A. dioica A. St.-Hil., have confirmed their folk medicinal properties for the treatment of inflammatory disease (Chavan et al, 2010(Chavan et al, , 2011(Chavan et al, , 2012aDe Sousa et al, 2010;Formagio et al, 2013a,b;Yeo et al, 2011). Previous studies performed by our research group as well as others have shown that the extract, essential oil, and identified compounds obtained from the leaves and bark of Annona species exert anti-inflammatory and antinociceptive effects (Chavan et al, 2010(Chavan et al, , 2011(Chavan et al, , 2012aDe Sousa et al, 2010;Formagio et al, 2013a,b;Yeo et al, 2011).…”

Section: Discussionmentioning

confidence: 81%

Analysis of the anti-inflammatory and chemopreventive potential and description of the antimutagenic mode of action of theAnnona crassifloramethanolic extract

Rocha

Kassuya

Formagio

et al. 2015

Pharmaceutical Biology

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Analgesic and Antiinflammatory Activity of Kaur‐16‐en‐19‐oic acid from Annona reticulata L. Bark

Cited by 33 publications

References 18 publications

Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Analysis of the anti-inflammatory and chemopreventive potential and description of the antimutagenic mode of action of theAnnona crassifloramethanolic extract

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