Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model

Tatsuo, M.A.K.F.; Carvalho, Wellington Marçal de; Silva, C. V.; Miranda, A. E. G.; Ferreira, Sérgio Henrique; Francischi, Janetti Nogueira de

doi:10.1007/bf01534437

Cited by 61 publications

(33 citation statements)

References 13 publications

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“…Tatsuo et al (96) studied the analgesic and antiinflammatory effects of metamizole, indomethacin and dexamethasone in a model of chronic inflammation (adjuvant-induced arthritis in rats). Metamizole was shown to be more potent as an analgesic than as an anti-inflammatory agent, while indomethacin and dexamethasone also had a pronounced anti-inflammtory effect.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile

Nikolova

Tencheva

Voinikov

et al. 2012

Biotechnology & Biotechnological Equipment

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile

Nikolova

Tencheva

Voinikov

et al. 2012

Biotechnology & Biotechnological Equipment

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“…EGCG was brought into suspension in PBS. EGCG (100 mg/kg) or PBS was administered i.p., with treatment initiated on day 7 after arthritis induction when the first signs of joint inflammation and pain are usually noted and continued until day 16 (46,47). On day 17, animals were anesthetized for blood collection by cardiac puncture and then killed for biochemical and cytokine analysis.…”

Section: Preparation Of the Egcg Solutionmentioning

confidence: 99%

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production

Ahmed

Marotte

Kwan

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

121

134

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Regulation of IL-6 transsignaling by the administration of soluble gp130 (sgp130) receptor to capture the IL-6/soluble IL-6R complex has shown promise for the treatment of rheumatoid arthritis (RA). However, enhancing endogenous sgp130 via alternative splicing of the gp130 gene has not yet been tested. We found that epigallocatechin-3-gallate (EGCG), an anti-inflammatory compound found in green tea, inhibits IL-1␤-induced IL-6 production and transsignaling in RA synovial fibroblasts by inducing alternative splicing of gp130 mRNA, resulting in enhanced sgp130 production. Results from in vivo studies using a rat adjuvant-induced arthritis model showed specific inhibition of IL-6 levels in the serum and joints of EGCG-treated rats by 28% and 40%, respectively, with concomitant amelioration of rat adjuvant-induced arthritis. We also observed a marked decrease in membrane-bound gp130 protein expression in the joint homogenates of the EGCG-treated group. In contrast, quantitative RT-PCR showed that the gp130/IL-6R␣ mRNA ratio increased by ϳ2-fold, suggesting a possible mechanism of sgp130 activation by EGCG. Gelatin zymography results showed EGCG inhibits IL-6/soluble IL-6R-induced matrix metalloproteinase-2 activity in RA synovial fibroblasts and in joint homogenates, possibly via up-regulation of sgp130 synthesis. The results of these studies provide previously undescribed evidence of IL-6 synthesis and transsignaling inhibition by EGCG with a unique mechanism of sgp130 up-regulation, and thus hold promise as a potential therapeutic agent for RA.rheumatoid arthritis ͉ alternative splicing ͉ cytokine therapy ͉ pharmacology ͉ therapeutics

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“…Mechanical allodynia, thermal hyperalgesia and pain on joint movement (joint hyperalgesia), which are prominent features in arthritic pain, have proved to be present in it (Tatsuo et al, 1994;Jasmin et al, 1998;Bertorelli et al, 1999). The time courses of their progression after the CFA inoculation, however, have not been fully analyzed.…”

mentioning

confidence: 99%

Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics

Nagakura¹,

Okada²,

Kohara³

et al. 2003

J Pharmacol Exp Ther

161

140

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The complete Freund's adjuvant (CFA)-induced arthritic rat model has extensively served as a laboratory model in the study of arthritic pain. However, the time courses of allodynia and hyperalgesia and the efficacies of different analgesics have not fully been analyzed in this model. Mechanical allodynia, thermal and joint hyperalgesia, and other disease development parameters (body weight, mobility, paw volume, and joint stiffness) were measured on postinoculation days (PIDs) 0 to 28 in rats. Acute analgesic efficacies of drugs were evaluated on PID 9 when degrees of allodynia, hyperalgesia, and joint stiffness in the ipsilateral paw reached almost the maximum, although those in the contralateral paw changed only slightly. In the ipsilateral paw, thermal hyperalgesia reached the maximum on PID 1, whereas mechanical allodynia and joint hyperalgesia progressively developed during the first 7 or 8 days, being tuned in to arthritis development. In the contralateral paw, thermal hyperalgesia never occurred, whereas mechanical allodynia and joint hyperalgesia developed after PID 11. Morphine and tramadol had full efficacies for all the pain parameters tested at sedation-inducing doses. Indomethacin and diclofenac significantly but partially improved thermal and joint hyperalgesia. Amitriptyline significantly reduced thermal and joint hyperalgesia only at sedation-inducing dose. Acetaminophen, carbamazepine, and gabapentin had, at the most, very small efficacies. In conclusion, the present study provided integrated information about the time course of pain and other disease development parameters in the CFA-induced arthritic rats, and clarified acute efficacies of different categories of analgesics for the allodynia and hyperalgesia.The complete Freund's adjuvant (CFA)-induced arthritic rat model has extensively served as a laboratory model in the study of arthritic pain. Mechanical allodynia, thermal hyperalgesia and pain on joint movement (joint hyperalgesia), which are prominent features in arthritic pain, have proved to be present in it (Tatsuo et al., 1994;Jasmin et al., 1998;Bertorelli et al., 1999). The time courses of their progression after the CFA inoculation, however, have not been fully analyzed. The first aim in the present study, therefore, was to provide integrated information about the time courses of pain (mechanical allodynia, thermal hyperalgesia, and joint hyperalgesia) and other disease development (body weight, mobility, paw volume, and joint stiffness) parameters after the CFA inoculation into the single hind paw in rats. Surprisingly, there are no studies that have fully evaluated the analgesic efficacies of different categories of analgesics on mechanical allodynia, thermal hyperalgesia, and joint hyperalgesia in the CFA-induced arthritic rat model. The second aim in the present study, therefore, was to investigate this issue. Antipyretics (e.g., acetaminophen) and nonsteroidal anti-inflammatory drugs (e.g., indomethacin and diclofenac) are the first line drugs in the treatment of arth...

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Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model

Cited by 61 publications

References 13 publications

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production

Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics

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