Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents

Abstract

The analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 glkg) P.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5-2mg/kg i.v.) to anaesthetized rats induced a dose-related hypertension inhibited by alpha-blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25-1 g/kg p.0.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg P.o.), a major triterpene obtained from EE, produced the same effect. The tail Rick response of mice was not influenced by either extract. EE (0.5 and 1 glkg) and glutinol(30 mglkg) P.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast-induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process.

Antioxidant Capacity Determination in Plants and Plant‐Derived Products: A Review

“…HPTLC [94] was also used for the screening and quantitation of phytochemicals present in Scoparia dulcis , known for many health benefits [95] (see Table 3). After application of the anisaldehyde-sulphuric acid visualization reagent, the spotted plate was exposed to UV radiation (254 and 366 nm) and multicolored bands at various intensities were noticed.…”

Modulatory Effect ofScoparia dulcisin Oxidative Stress-Induced Lipid Peroxidation in Streptozotocin Diabetic Rats

“…S. dulcis has traditionally been used as one of the remedies for stomach troubles, 7 hypertension, 8 diabetes, 9 inflammation, 10 bronchitis, 11 and hemorrhoids and hepatosis 7 and as an analgesic and antipyretic. 10 A number of different compounds, including scoparic acid A, scoparic acid B, 12 scopadulcic acid A and B, scopadulciol, 13 and scopadulin, 14 have been identified as contributors to the observed medicinal effect of the plant.…”

Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes

“…In these regions, fresh or dried S. dulcis plants have been traditionally used as remedies for stomach troubles (6), hypertension (7), diabetes (8), bronchitis (9), and as analgesic and antipyretic agents (10). A number of different principles such as scoparic acid A, scoparic acid B, scopadulcic acid A and B, scopadulciol, and scopadulin (11) have been shown to contribute to the observed medicinal effect of the plant.…”