Analgesic and Antioxidant Activity of Mangiferin and Its Derivatives: the Structure Activity Relationship

Dar, Ahsana; Faizi, Shaheen; Naqvi, Sabira; Roome, Talat; Zikr-ur-Rehman, Sadia; Ali, Muhammad; Firdous, S.; Moin, Syed Tarique

doi:10.1248/bpb.28.596

Cited by 230 publications

(185 citation statements)

References 29 publications

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“…The antioxidant activity is traceable already in the healthy condition, but it is strikingly amplified in the inflammatory and infectious, including diabetes, states [7,8]. In our studies, mangiferin decreased diabetic-enhanced lipid peroxidation products -thiobarbituric acid reactive substances (TBARS) formed as degradation products of fats -down to the healthy level.…”

supporting

confidence: 49%

Mangiferin - A Nutraceutical with Clinical Implications

Pokorski¹

2014

Vitam Miner

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supporting

confidence: 49%

Mangiferin - A Nutraceutical with Clinical Implications

Pokorski¹

2014

Vitam Miner

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“…Moreover, mangiferin showed hepatoprotective activity against carbon tetrachloride induced liver injury further supporting the free radical scavenging property in the in vivo system. Another molecules acetyl and cinnamoyl derivatives were found to be less active than mangiferin whereas, methyl and 3,6,7-trimethylether tetraacetate derivatives were inactive (Dar et al, 2005). Vieira et al (2009) also evaluated the antioxidant activity of methanolic extract of Bombax ceiba using (i) ability to scavenge DPPH and hydroxyl free radicals; (ii) action against lipid peroxidation and (iii) effect on myeloperoxidase activity.…”

Section: Antioxidants Activitymentioning

confidence: 99%

Ethnomedicinal and pharmacological activities of Mochrus (Bombax ceiba Linn.): An overview

Rani¹,

Rahman²,

Sultana³

2016

TANG [HUMANITAS MEDICINE]

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Traditional system of medicine mentioned the use of plants in treatment of various human ailments. Mochrus (Bombax ceiba Linn.) is one of the medicinal plants used in Unani medicine since time immemorial. It is a very tall tree with approximately 150 feet height. It is widely found in temperate Asia, tropical Asia, Africa and Australia. In India, it can be found at altitudes up to 1500 m. In peninsular India, the tree is very common in the dry as well as moist deciduous forests and near rivers. It is reported to possess qabiz (constipative); mujaffif (siccative); muqawwi rehm (uterine tonic); nafi sailan rehm (beneficial in leucorrhea); mumsik wa mughalliz mani (increase consistency of semen); muallide mani (production of semen); habise tams (amenorrhoic); dafi fasaad khoon wa safra (purifies blood and bile); taskeen hiddat aza (hotness of organs); muqawi asnan wa lissa (tonic to teeth and gums) etc. Ethnobotanical studies prove that it is used in diarrhoea, asthma, impotency, boils, wounds, leprosy, pimples and many other skin diseases. It is an anthelmintic remedy since ancient time. Pharmacological studies like hypotensive, antioxidant, analgesic, anti-inflammatory, antipyretic, antiangiogenic, antibacterial, cytotoxic, hepatoprotective, diuretic, anthelmintic, anticancer, spermatogenic and antihelicobacter pylori activities have been evaluated for various parts of this plant that confirms to its use in classical medicine.

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“…It possesses several pharmacological activities like antioxidant (Rodriguez et al, 2006), anti-inflammatory (Saha et al, 2016), anti-viral (Zheng and Lu, 1990), analgesic (Dar et al, 2005), immunomodulatory (Leiro et al, 2004;Sarkar et al, 2004), antidiabetic (Ojewole, 2005), besides other's. Amongst all these, the ability of Mgf to act as a potent antioxidant by scavenging free radicals is known to be of immense importance for preventing the potential DNA damage and for inhibiting the growth of cancer cells by inducing cellular apoptosis (Minglin et al, 2016;Takeda et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Enhancing biopharmaceutical attributes of phospholipid complex-loaded nanostructured lipidic carriers of mangiferin: Systematic development, characterization and evaluation

Khurana

Bansal

Beg

et al. 2017

International Journal of Pharmaceutics

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Mangiferin (Mgf), largely expressed out from the leaves and stem bark of Mango, is a potent antioxidant. However, its in vivo activity gets tremendously reduced owing to poor aqueous solubility and inconsistent gastrointestinal absorption, high hepatic first-pass metabolism and high P-gp efflux. The current research work, therefore, was undertaken to overcome the biopharmaceutical hiccups by developing the Mgfphospholipid complex (PLCs) loaded in nanostructured lipidic carriers (NLCs). The PLCs and NLCs were prepared using refluxing, solvent evaporation and hot emulsification technique, respectively with various molar ratios of Mgf and Phospholipon 90 G, i.e., 1:1; 1:2; and 1:3. The complex was evaluated for various physicochemical parameters like drug content (96.57%), aqueous solubility (25-fold improved) and oil-water partition coefficient (10-fold enhanced). Diverse studies on the prepared complex using FTIR, DSC, PXRD and SEM studies ratified the formation of PLCs at 1:1 ratio. The PLCs were further incorporated onto NLCs, which were systematically optimized employing a face centered cubic design (FCCD), while evaluating for particle size, zeta potential, encapsulation efficiency and in vitro drug release as the CQAs. Caco-2 cell line indicated insignificant cytotoxicity, and P-gp efflux, bi-directional permeability model and in situ perfusion studies specified enhanced intestinal permeation parameters. In vivo pharmacokinetic studies revealed notable increase in the values of Cmax (4.7-fold) and AUC (2.1-fold), respectively, from PLCs-loaded NLCs vis-à-vis Mgf solution. In a nutshell, the promising results observed from the present research work signified boosted biopharmaceutical potential of the optimized PLCs-loaded NLCs for potentially augmenting the therapeutic efficacy of Mgf.

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Analgesic and Antioxidant Activity of Mangiferin and Its Derivatives: the Structure Activity Relationship

Cited by 230 publications

References 29 publications

Mangiferin - A Nutraceutical with Clinical Implications

Mangiferin - A Nutraceutical with Clinical Implications

Ethnomedicinal and pharmacological activities of Mochrus (Bombax ceiba Linn.): An overview

Enhancing biopharmaceutical attributes of phospholipid complex-loaded nanostructured lipidic carriers of mangiferin: Systematic development, characterization and evaluation

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