Analgesic and antipyretic natural products

Shilpi, Jamil A.; Uddin, Shaikh Jamal

doi:10.1016/bs.armc.2020.03.003

Cited by 12 publications

(7 citation statements)

References 103 publications

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“…Although pain may indicate injury of organs, nervous system-derived pain should be relieved beforehand to prevent the deterioration of the quality of the patient’s life. Morphine, a well-known analgesic, was isolated from opium 200 years ago [ 86 ]. Nowadays other natural products are assayed for their pain-relieving activity.…”

Section: Biological Activitymentioning

confidence: 99%

Phytochemical Composition and Biological Activities of Scorzonera Species

Lendzion

Gornowicz

Bielawski

et al. 2021

IJMS

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The genus Scorzonera comprises nearly 200 species, naturally occurring in Europe, Asia, and northern parts of Africa. Plants belonging to the Scorzonera genus have been a significant part of folk medicine in Asia, especially China, Mongolia, and Turkey for centuries. Therefore, they have become the subject of research regarding their phytochemical composition and biological activity. The aim of this review is to present and assess the phytochemical composition, and bioactive potential of species within the genus Scorzonera. Studies have shown the presence of many bioactive compounds like triterpenoids, sesquiterpenoids, flavonoids, or caffeic acid and quinic acid derivatives in extracts obtained from aerial and subaerial parts of the plants. The antioxidant and cytotoxic properties have been evaluated, together with the mechanism of anti-inflammatory, analgesic, and hepatoprotective activity. Scorzonera species have also been investigated for their activity against several bacteria and fungi strains. Despite mild cytotoxicity against cancer cell lines in vitro, the bioactive properties in wound healing therapy and the treatment of microbial infections might, in perspective, be the starting point for the research on Scorzonera species as active agents in medical products designed for miscellaneous skin conditions.

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Section: Biological Activitymentioning

confidence: 99%

Phytochemical Composition and Biological Activities of Scorzonera Species

Lendzion

Gornowicz

Bielawski

et al. 2021

IJMS

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“…Regarding their chemical structure, capsaicinoids contain an amide bond, which is responsible for their pungency [51], instead of the ester bond found in capsinoids (Figure 1). In addition, the chemical backbone of capsaicinoid molecules is composed of a fatty acid amide linked to vanillylamine moiety; while that of capsinoids molecules contains a fatty acid ester bonded to vanillyl alcohol (Figure 1).…”

Section: Characteristics Of Capsaicinoids and Capsinoidsmentioning

confidence: 99%

Antifungal Potential of Capsaicinoids and Capsinoids from the Capsicum Genus for the Safeguarding of Agrifood Production: Advantages and Limitations for Environmental Health

et al. 2022

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Opportunistic pathogenic fungi arise in agricultural crops as well as in surrounding human daily life. The recent increase in antifungal-resistant strains has created the need for new effective antifungals, particularly those based on plant secondary metabolites, such as capsaicinoids and capsinoids produced by Capsicum species. The use of such natural compounds is well-aligned with the One Health approach, which tries to find an equilibrium among people, animals, and the environment. Considering this, the main objective of the present work is to review the antifungal potential of capsaicinoids and capsinoids, and to evaluate the environmental and health impacts of biofungicides based on these compounds. Overall, capsaicinoids and their analogues can be used to control pathogenic fungi growth in plant crops, as eco-friendly alternatives to pest management, and assist in the conservation and long-term storage of agrifood products. Their application in different stages of the agricultural and food production chains improves food safety, nutritional value, and overcomes antimicrobial resistance, with a lower associated risk to humans, animals, and the environment than that of synthetic fungicides and pesticides. Nevertheless, research on the effect of these compounds on bee-like beneficial insects and the development of new preservatives and packaging materials is still necessary.

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“…The animals are placed on textured drums (1 1 4 inch diameter) to avoid slipping. When an animal drops onto the individual sensing platforms, the result is recorded.…”

Section: Motor Coordination Test (Rotarod Test)mentioning

confidence: 99%

“…Pain is the most well-known unpleasant experience which protects a human from injuries [ 1 , 2 ]. Injuries cause acute or chronic pain.…”

Section: Introductionmentioning

confidence: 99%

Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, Hemiscorpius lepturus

et al. 2021

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Hemiscorpius lepturus scorpion stings do not induce considerable pain based on epidemiological surveys conducted in the southwest part of Iran. Accordingly, this study was aimed to identify the analgesic molecule in H. lepturus venom by analyzing a cDNA library of the scorpion venom gland looking for sequences having homology with known animal venom analgesic peptides. The analgesic molecule is a cysteine rich peptide of 55 amino acids. the synthetic peptide was deprotected and refolded. RP-HPLC, Ellman’s, and DLS assays confirmed the refolding accuracy. Circular dichroism (CD) showed helix and beta sheet contents. This peptide, called leptucin, demonstrated 95% analgesic activity at the dose of 0.48 mg/kg in hot plate assay. Leptucin at the doses of 0.32, 0.48, and 0.64 mg/kg showed 100% activity in thermal tail flick test. No hemolysis or cytotoxicity was observed at 8 and 16 µg. Histopathology evaluations indicated no hepatotoxicity, nephrotoxicity, and cardiotoxicity. We thus report that leptucin is the analgesic agent of H. lepturus venom. Regarding the high in vivo efficacy of leptucin and the fact it shows no observable toxicity, it could be suggested as a drug lead in a preclinical study of acute pain as well as the study of its mechanism of action.

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Analgesic and antipyretic natural products

Cited by 12 publications

References 103 publications

Phytochemical Composition and Biological Activities of Scorzonera Species

Phytochemical Composition and Biological Activities of Scorzonera Species

Antifungal Potential of Capsaicinoids and Capsinoids from the Capsicum Genus for the Safeguarding of Agrifood Production: Advantages and Limitations for Environmental Health

Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, Hemiscorpius lepturus

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