Analgesic and potentiated photothermal therapy with ropivacaine-loaded hydrogels

Zhang, Jiqian; Zhu, Shasha; Zhao, Ming; Zhou, Mengni; Zhu, Xiaoyan; Qing, Xin; Yang, Zhilai; Wei, Pengfei; Zhang, Guoying; He, Weiling; Yan, Yu; Liu, Xuesheng

doi:10.7150/thno.81325

Cited by 12 publications

(5 citation statements)

References 42 publications

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“…Rop is a long‐acting amide‐type local anesthetic that induces nerve blockade by reversible inhibition of sodium ion influx into nerve fibers. [ 22 ] Due to its efficacy, reduced motor blockade propensity, as well as decreased potential for central nervous system and cardiac toxicity, Rop represents a significant choice for regional anesthesia and postoperative pain management. [ 23 ] We chose Rop as the analgesic drug to be loaded within the CSMN.…”

Section: Resultsmentioning

confidence: 99%

A pH‐Responsive Core‐Shell Microneedle Patch with Self‐Monitoring Capability for Local Long‐Lasting Analgesia

Zhang,

Zeng,

Xiong

et al. 2023

Adv Funct Materials

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Postoperative pain, as a common and significant healthcare issue, has always been the focus of attention in the field of anesthesia for its control and treatment. In the present study, a pH‐responsive microneedle (MN) patch is developed for sustained incisional analgesia after surgery. The MN patch has a 10 × 10 MN array within 0.5 cm2 area, and each MN features a complete core‐shell structure, with a needle height of ≈850 µm. Upon application, the MNs fully implant in the skin within 15 min due to the rapid dissolution of the water‐soluble backing layer. The acidic microenvironment at the surgical site (pH 6.8–7.0) interacts with the pH‐reactive medium in the MN shell, triggering the shell rupture. This process enables the smooth release of encapsulated local anesthetic drug (Ropivacaine, Rop) microcrystals, extending local anesthesia duration to over 72 h at a drug concentration of 100 mg mL−1. Additionally, the MN patch intelligently modulates drug release based on the postoperative pain behavior, which correlates with the pH value of the surgical incision microenvironment. This responsive feature results in a prolonged and personalized analgesic effect, addressing the limitations of existing invasive treatments in postoperative pain management.

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Section: Resultsmentioning

confidence: 99%

A pH‐Responsive Core‐Shell Microneedle Patch with Self‐Monitoring Capability for Local Long‐Lasting Analgesia

Zhang,

Zeng,

Xiong

et al. 2023

Adv Funct Materials

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“…Our recent study showed that a hydrogel co-loaded with the TLR7 agonists imiquimod and ropivacaine increased the infiltration of CD8 + T cells into the residual tumor tissues to prevent tumor recurrence [ 66 ]. Moreover, we designed a PF127 hydrogel doped with ropivacaine, indocyanine green (ICG), and imiquimod for painless enhanced photothermal therapy effect [ 67 ]. In this study, we found that a PF127 hydrogel loaded with ropivacaine and cisplatin upregulated MHC-I in tumors by destroying autophagy and increasing the infiltration of CD8 + T cells into the tumors, thus increasing the anti-tumor effect.…”

Section: Discussionmentioning

confidence: 99%

Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy

Qing,

Dou,

Wang

et al. 2023

J Nanobiotechnol

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Chemotherapy can cause severe pain for patients, but there are currently no satisfactory methods of pain relief. Enhancing the efficacy of chemotherapy to reduce the side effects of high-dose chemotherapeutic drugs remains a major challenge. Moreover, the treatment of chemotherapy-induced peripheral neuropathic pain (CIPNP) is separate from chemotherapy in the clinical setting, causing inconvenience to cancer patients. In view of the many obstacles mentioned above, we developed a strategy to incorporate local anesthetic (LA) into a cisplatin-loaded PF127 hydrogel for painless potentiated chemotherapy. We found that multiple administrations of cisplatin-loaded PF127 hydrogels (PFC) evoked severe CIPNP, which correlated with increased pERK-positive neurons in the dorsal root ganglion (DRG). However, incorporating ropivacaine into the PFC relieved PFC-induced CIPNP for more than ten hours and decreased the number of pERK-positive neurons in the DRG. Moreover, incorporating ropivacaine into the PFC for chemotherapy is found to upregulate major histocompatibility complex class I (MHC-I) expression in tumor cells and promote the infiltration of cytotoxic T lymphocytes (CD8+ T cells) in tumors, thereby potentiating chemotherapy efficacy. This study proposes that LA can be used as an immunemodulator to enhance the effectiveness of chemotherapy, providing new ideas for painless cancer treatment.

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“…The pain induced by PTT was accompanied by the activation of transient receptor potential vanilloid type-1 due to the increase in temperature. Compared with opioid analgesia, introducing local anesthetic ropivacaine into the hydrogel loaded with indocyanine could alleviate the pain caused by PTT and play a long-lasting analgesic role, providing a new understanding of analgesia and increasing photothermal therapy [ 76 ]. Dong et al developed a treatment strategy that could provide enhanced PTT while inhibiting PTT-induced inflammatory response.…”

Section: Nanoformulations Combined With Photothermal Therapy For Pain...mentioning

confidence: 99%

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Xu,

Dong,

et al. 2023

Pharmaceutics

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The use of nanomaterials in drug delivery systems for pain treatment is becoming increasingly common. This review aims to summarize how nanomaterial-based drug delivery systems can be used to effectively treat and relieve pain, whether via the delivery of a single drug or a combination of multiple therapeutics. By utilizing nanoformulations, the solubility of analgesics can be increased. Meanwhile, controlled drug release and targeted delivery can be realized. These not only improve the pharmacokinetics and biodistribution of analgesics but also lead to improved pain relief effects with fewer side effects. Additionally, combination therapy is frequently applied to anesthesia and analgesia. The co-encapsulation of multiple therapeutics into a single nanoformulation for drug co-delivery has garnered significant interest. Numerous approaches using nanoformulation-based combination therapy have been developed and evaluated for pain management. These methods offer prolonged analgesic effects and reduced administration frequency by harnessing the synergy and co-action of multiple targets. However, it is important to note that these nanomaterial-based pain treatment methods are still in the exploratory stage and require further research to be effectively translated into clinical practice.

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Analgesic and potentiated photothermal therapy with ropivacaine-loaded hydrogels

Cited by 12 publications

References 42 publications

A pH‐Responsive Core‐Shell Microneedle Patch with Self‐Monitoring Capability for Local Long‐Lasting Analgesia

A pH‐Responsive Core‐Shell Microneedle Patch with Self‐Monitoring Capability for Local Long‐Lasting Analgesia

Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

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