Analgesic, anti-inflammatory, and anti-oxidant activities of <i>Phlogacanthus thyrsiflorus</i> leaves

Das, Biplab; Al-Amin, Md.; Chowdhury, Nusrat Nabila; Majumder, Md. Fakhar Uddin; Uddin, Mohammad Nasir; Pavel, Md. Adit Muktadir

doi:10.1515/jbcpp-2013-0164

Cited by 10 publications

(4 citation statements)

References 19 publications

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“…Data mining or literature review on all 61 species of medicinal plants for their reported pharmacological activities revealed that 52 of them have been already subjected to scientific studies and only eight species remained unstudied ( Table 1 ). 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 Most of the LAMP grow in the temperate, subtropical and tropical agroclimatic regions and are distributed worldwide. Consequently, same or similar medicinal plants are found common in traditional medicines practiced in the Asia–Pacific and African countries, although they may be used for treating different ailments in different countries.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological, ethnopharmacological, and botanical evaluation of subtropical medicinal plants of Lower Kheng region in Bhutan

Wangchuk

Yeshi²,

Jamphel

2017

Integrative Medicine Research

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Section: Discussionmentioning

confidence: 99%

Pharmacological, ethnopharmacological, and botanical evaluation of subtropical medicinal plants of Lower Kheng region in Bhutan

Wangchuk

Yeshi²,

Jamphel

2017

Integrative Medicine Research

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“…DISCUSSION: Root extracts of Phlogacanthus thyrsiflorus Nees., showed important phytoconstituents such as Phenolics, flavonoids, and tannins which are a major group of compounds that act as natural antioxidants or free radical scavengers which possess antimicrobial, antiallergic, anti-mutagenic, anti-inflammatory and anti-carcinogenic properties 22,23 . In another study, the presence of tannins, flavonoids, saponins, carbohydrates, steroids, alkaloids, reducing sugar, and terpenoids were reported in the leave extracts of Phlogacanthus thyrsiflorus 24 . The higher amount of phenolic and flavonoid contents are detected in the present study which corresponds to stronger antioxidant capacity.…”

Section: Ferric Reducing Antioxidant Propertymentioning

confidence: 93%

Untitled

2019

IJPSR

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The Phlogacanthus thyrsiflorus roots have been used by the tribal population of western Assam to treat the hepatic disorder. The present study focuses on phytochemical screening, GC-MS analysis and in-vitro antioxidant activities using different extracts. Plant total phenolics, flavonoids, reducing power assay and antioxidant activity was evaluated. DPPH, FRAP, ABTS, Metal chelating activity, and H 2 O 2 free radical scavenging activity were studied. The screening from extracts showed the presence of phenols, flavonoids, tannins, resins, terpenoids, alkaloids, glycosides, cardiac glycosides, steroids. The highest concentration of total phenolics, flavonoids, reducing power and total antioxidant activity was found in the hydro-alcoholic extract of RoPt. The results of the radical scavenging activity in 70% ethanolic extract showed better IC 50 value in DPPH (265.87 ± 17.58), ABTS (17.89 ± 1.18) and H 2 O 2 (17.89 ± 1.05) µg/ml respectively. EC 50 value of 535.16 ± 34.82 was found in 70% ethanolic against 1471.32 ± 19.77 µg/ml of acetone extract whereas the FRAP showed high FeSO 4 .7H 2 O concentration in acetone extract with 820 ± 9.1 µM/ml. The major chemical constituents that were identified in GC-MS analysis were 2R-Acetoxymethyl-1,3,3-Trimethyl-4T-(3-Methyl-2-Buten-1-YL)-1T-Cyclohexanol (71.243%) and 2,4,4-Trimethyl-3-Hydroxymethyl -5A-(3-Methyl-But-2-Enyl)-Cyclohexene (88.107%) in hydro-alcoholic and acetone extracts respectively. The study showed an enhanced phenolic and flavonoid concentration and radical scavenging activity in the 70% ethanol extracts of RoPt which are the good source of antioxidants showing potential in preventing much free radical-mediated disorder.

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“…Presence of total avonoid is found to be higher in methanol leaf extract of Justicia adhatoda Linn. In a study conducted by (Das et al 2015) to investigate the potential role of a methanol extract from Phlogacanthus thyrsiformis Nees. leaves, avonoid were discovered in trace concentrations.…”

Section: Total Avonoid Contentmentioning

confidence: 99%

Comparative study of Phytochemicals, antioxidant and antibacterial activity of Phlogacanthus thyrsiformis Nees. and Justicia adhatoda Linn

Ningthoujam,

Singh,

Laldingliani

et al. 2023

Preprint

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Phlogacanthus thyrsiformis Nees. and Justicia adhatoda Linn., belongs to the family Acanthaceae and is a traditional medicinal plant native to Asia and widely used in medicine of Siddha, Ayurveda, Unani, homeopathy and naturopathy. The present study addresses the comparative study of phytochemicals, antioxidant, antibacterial activity and GC-MS analysis of matured dried leaves of Phlogacanthus thyrsiformis Nees. and Justicia adhatoda Linn., using crude extracts of acetone and methanol. The phytochemical analysis shows the presence of glycosides, tannins, proteins, triterpenoids, saponins, phenols and flavonoids in both plant extracts. Ferric chloride reducing power and DPPH radical scavenging assay were also performed to test the antioxidant activity and the IC50 value was also calculated and a positive result was obtained. The crude extracts were also tested against three gram negative and two gram-positive bacteria. All extracts showed dose-dependent antibacterial activity. GC-MS chromatogram analysis of the crude extracts revealed multiple peaks indicating the presence of numerous phytochemical compounds. The result clearly shows that more compounds were identified in Justicia adhatoda Linn. methanolic extract. In this comparative study, methanol extract was found to have more activity in testing phytochemical, antioxidant and antibacterial activity and J.adhatoda Linn. has greater potential medicinal value compared to P.thyrsiformis Nees.

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Analgesic, anti-inflammatory, and anti-oxidant activities of Phlogacanthus thyrsiflorus leaves

Cited by 10 publications

References 19 publications

Pharmacological, ethnopharmacological, and botanical evaluation of subtropical medicinal plants of Lower Kheng region in Bhutan

Pharmacological, ethnopharmacological, and botanical evaluation of subtropical medicinal plants of Lower Kheng region in Bhutan

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Comparative study of Phytochemicals, antioxidant and antibacterial activity of Phlogacanthus thyrsiformis Nees. and Justicia adhatoda Linn

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