Analgesic, Anti-inflammatory, Antipyretic, and In Silico Measurements of Sonneratia caseolaris (L.) Fruits from Sundarbans, Bangladesh

Kundu, Pritam; Debnath, Shovan Lal; Devnath, Hiron Saraj; Saha, Lopa; Sadhu, Samir Kumar

doi:10.1155/2022/1405821

Cited by 10 publications

(9 citation statements)

References 53 publications

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“…The amount of total polyphenol, avonoid and antioxidant activity of E. glaucum seed extract was considerable. Analgesic effect is also in uenced by the free radicals and in ammation [35]. Therefore, pain inhibition action of the extract could be partially credited to the action of the extract against free radicals and anti-in ammation.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-Urolithiatic Effects of Ensete glaucum (Roxb.) Cheesman Seed Aqueous Extract in Mice

Le¹,

Ly²,

Le³

2023

Preprint

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Ensete glaucum seeds, being known as one of traditional medicine, are commonly used in folk medicine to treat urinary stones, edema, and osteoarthritis-related problems. However, no scientific evidence has been reported to support these uses. This study focused on investigating the antinociceptive and antiurolithiatic activities of E. glaucum seed aqueous extract (EGE). The antinociceptive effect of EGE was evaluated in mice using thermal (hot plate test) and chemical (acetic acid and formalin-induced nociception test) pain models at various doses (50, 100, 200, 400 mg/kg; p.o.). The anti-urolithiatic activity of the EGE (200, 400 mg/kg; p.o.) was assessed in the sodium glyoxylate-induced urolithiasis in mice and in vitro nucleation and aggregation assays. The analgesic effect of EGE was detected at several doses via peripheral and central antinociceptive mechanisms in the acetic acid-induced writhing (50-400 mg/kg), hot plate (100-200 mg/kg), and formalin-induced licking (200-400 mg/kg) tests. EGE had potential against urolithiasis through its ability to modify several serum and urine biochemical parameters on glyoxylate-induced nephrolithiasis. The extract at the dose of 400 mg/kg significantly improved the inflammatory cells, kidney tissue structure, and renal calcification. The extract also exhibited significant anti-urolithiatic, anti-inflammatory, and antioxidant activities in some in vitro models. These outcomes suggest that E. glaucum aqueous seed extract possesses antinociceptive activity and may aid in the prevention of urinary stones. Further studies are needed to elucidate the effectiveness of E. glaucum seeds in the analgesic activity and management of urolithiasis disease.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-Urolithiatic Effects of Ensete glaucum (Roxb.) Cheesman Seed Aqueous Extract in Mice

Le¹,

Ly²,

Le³

2023

Preprint

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“…The DPPH scavenging assay is the most widely used method for measuring anti-radical activity due to its rapidness, stability, and simplicity of analysis [ 26 ]. Herein, the antioxidant activity of the cellulose-WTP, cellulose-SCB, MIO-NPs, SCB/MIO-NCPs, and WTP/MIO-NCPs was measured against the DPPH according to the protocol outlined by Kundu et al [ 27 ]. Initially, the DPPH was dissolved in a solution of methanol, and the concentration was adjusted to 0.007886% ( w / v ).…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Magnetic Iron Oxide-Incorporated Cellulose Composite Particles: An Investigation on Antioxidant Properties and Drug Delivery Applications

et al. 2023

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In recent years, polymer-supported magnetic iron oxide nanoparticles (MIO-NPs) have gained a lot of attention in biomedical and healthcare applications due to their unique magnetic properties, low toxicity, cost-effectiveness, biocompatibility, and biodegradability. In this study, waste tissue papers (WTP) and sugarcane bagasse (SCB) were utilized to prepare magnetic iron oxide (MIO)-incorporated WTP/MIO and SCB/MIO nanocomposite particles (NCPs) based on in situ co-precipitation methods, and they were characterized using advanced spectroscopic techniques. In addition, their anti-oxidant and drug-delivery properties were investigated. Field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) analyses revealed that the shapes of the MIO-NPs, SCB/MIO-NCPs, and WTP/MIO-NCPs were agglomerated and irregularly spherical with a crystallite size of 12.38 nm, 10.85 nm, and 11.47 nm, respectively. Vibrational sample magnetometry (VSM) analysis showed that both the NPs and the NCPs were paramagnetic. The free radical scavenging assay ascertained that the WTP/MIO-NCPs, SCB/MIO-NCPs, and MIO-NPs exhibited almost negligible antioxidant activity in comparison to ascorbic acid. The swelling capacities of the SCB/MIO-NCPs and WTP/MIO-NCPs were 155.0% and 159.5%, respectively, which were much higher than the swelling efficiencies of cellulose-SCB (58.3%) and cellulose-WTP (61.6%). The order of metronidazole drug loading after 3 days was: cellulose-SCB < cellulose-WTP < MIO-NPs < SCB/MIO-NCPs < WTP/MIO-NCPs, whereas the sequence of the drug-releasing rate after 240 min was: WTP/MIO-NCPs < SCB/MIO-NCPs < MIO-NPs < cellulose-WTP < cellulose-SCB. Overall, the results of this study showed that the incorporation of MIO-NPs in the cellulose matrix increased the swelling capacity, drug-loading capacity, and drug-releasing time. Therefore, cellulose/MIO-NCPs obtained from waste materials such as SCB and WTP can be used as a potential vehicle for medical applications, especially in a metronidazole drug delivery system.

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“…DACB-43821 for future reference). In our previous paper, we reported the preparation of the extract [ 11 ]. The remaining part of that extract was used to conduct the biological tests mentioned in this manuscript.…”

Section: Methodsmentioning

confidence: 99%

“…Male Swiss albino mice ( Mus musculus ) were bought from Jahangirnagar University, Bangladesh. Those were placed in the animal house for adaptation and used to conduct biological experiments mentioned in our previous literature [ 11 ]. For conducting the antidiarrheal and neuropharmacological tests reported in this manuscript, the animals were handled in the same way.…”

Section: Methodsmentioning

confidence: 99%

“…Regarding the traditional uses of fruits and the existence of important medicinal constituents, we set up our target to evaluate the phytochemical and pharmacological properties. One of our previous studies reported the phytochemicals present and antioxidative, analgesic, anti-inflammatory, and antipyretic effects [ 11 ]. Upon continuation of our project, here we have reported in vivo antidiarrheal, CNS depressant, anthelmintic, cytotoxic, and in vitro blood coagulant activities along with molecular docking and ADMET study.…”

Section: Introductionmentioning

confidence: 99%

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Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Kundu

Debnath

Ahad

et al. 2023

BioMed Research International

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Sonneratia caseolaris (L.) is a common mangrove plant which has significant medicinal value in traditional medicine. Ethanol extract from the fruits of S. caseolaris (SCE) was used in this project to explore its different pharmacological effects considering its traditional usage. In the castor oil-induced diarrheal method, SCE significantly lengthened the latency of the first defecation period up to 95.8 and 119.4 min as well as lowering stool count by 43.3% and 64.4% at the doses of 250 and 500 mg/kg, respectively. In evaluating the neuropharmacological effect using the open-field model, a significant central nervous system (CNS) depressant nature was observed after a reduction in the no. of squares crossed by mice at various time intervals. In evaluating the blood coagulation effect, SCE significantly reduced blood clotting time at 5.86, 5.52, and 5.01 min at 25, 50, and 100 mg/ml doses, respectively. In the assessment of the anthelmintic effect, SCE significantly killed Paramphistomum cervi (P. cervi) where the death times of the nematodes were 40.3, 36.8, and 29.9 min at 12.5, 25, and 50 mg/ml doses, respectively. The extract showed a very poor cytotoxic effect in brine shrimp lethality bioassay. In molecular docking analysis, maslinic acid, oleanolic acid, luteolin, luteolin 7-O-β-glucoside, myricetin, ellagic acid, and R-nyasol showed the best binding affinities with the selected proteins which might be the credible reasons for eliciting pharmacological responses. Among these seven compounds, only luteolin 7-O-β-glucoside had two violations in Lipinski’s rule of five.

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Analgesic, Anti-inflammatory, Antipyretic, and In Silico Measurements of Sonneratia caseolaris (L.) Fruits from Sundarbans, Bangladesh

Cited by 10 publications

References 53 publications

Antinociceptive and Anti-Urolithiatic Effects of Ensete glaucum (Roxb.) Cheesman Seed Aqueous Extract in Mice

Antinociceptive and Anti-Urolithiatic Effects of Ensete glaucum (Roxb.) Cheesman Seed Aqueous Extract in Mice

Synthesis of Magnetic Iron Oxide-Incorporated Cellulose Composite Particles: An Investigation on Antioxidant Properties and Drug Delivery Applications

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

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