Analgesic–antiinflammatory properties of Proustia pyrifolia

Delporte, Carla; Backhouse, Nadine; Erazo, Silvia; Negrete, Rosa; Vidal, Paloma Oliveira; Silva, X.; López-Pérez, Jose Luis; Feliciano, Arturo San; Muñoz, Orlando

doi:10.1016/j.jep.2005.02.012

Cited by 64 publications

(48 citation statements)

References 21 publications

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“…Two classes of enzymes, cyclo-and lipoxygenases, are responsible for the synthesis of arachidonic acid metabolites, also known as eicosanoids; the first group catalyses the synthesis of prostaglandins and thromboxanes, and the second group is involved in the synthesis of leukotrienes and lipoxins (3,6) . Cyclooxygenase (COX), an enzyme important for the synthesis of prostaglandins, is present in three isoforms.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease

Romero

Artigiani

Costa

et al. 2008

Arq. Gastroenterol.

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-Background -Crohn's disease accompanied by nonspecific or idiopathic ulcerative proctocolitis corresponds to a condition called intestinal inflammatory disease. The immunoexpression of cyclooxygenase 2 (COX-2) in Crohn's disease becomes more marked with progression of the disease and the presence of wild-type p53 suppresses the transcription of COX-2. Aims -To investigate the immunoexpression of cyclooxygenase 1 (COX-1), COX-2 and p53 in Crohn's ileocolitis and to correlated this expression with clinical and histopathological parameters. Methods -Forty-five cases of Crohn's disease, 16 cases of actinic colitis (diseased-control group) and 11 cases without a history of intestinal disease (normal control group) were studied. Hematoxylin-eosin-stained sections were submitted to histopathological analysis and the immunohistochemical expression of COX-1, COX-2 and p53 was evaluated by the streptavidin-biotin-peroxidase method. Results -Sixty percent of the Crohn's disease patients were women and 40% were men, with 75.5% whites and 25.5% non-whites. The disease involved the terminal ileum in 44.5% of cases, ileum in 33.3%, colon in 20% and duodenum-ileum in 2.2%. A significant association was observed between COX-2 immunoreactivity and age ≤40 years. Histopathological analysis of Crohn's disease samples showed mild or moderate crypt distortion (57.8% and 35.6% of cases), atrophy (6.6%), mild, moderate and marked chronic inflammation (46.7%, 26.7% and 20%), acute inflammatory activity (93.3%), ulceration (24.4%), mucin depletion (37.8%), Paneth's cells (24.4%), intraepithelial lymphocytes (93.3%), and subepithelial collagen (6.7%). In the CD group, COX-1 immunoreactivity in epithelial and inflammatory cells was observed in 26.7% and 22.2% of cases, respectively.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease

Romero

Artigiani

Costa

et al. 2008

Arq. Gastroenterol.

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“…Gallic acid has been shown to have antioxidant [52,53], anti-inflammatory, cytotoxic and bactericidal activity [53], gastric protective action [53] and antiangiogenic activity [54]. -Sitosterol is reported to show antioxidant [55], anti-inflammatory [56], analgesic and anthelmintic [57] activity. It is also found to be effective in the treatment of benign prostatic hyperplasia [58].…”

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confidence: 99%

Simultaneous Quantification of Bergenin, (+)-Catechin, Gallicin and Gallic acid; and Quantification of β-Sitosterol using HPTLC from Bergenia ciliata (Haw.) Sternb. Forma ligulata Yeo (Pasanbheda)

Rathee¹,

Madhavi²,

Agrawal³

et al. 2010

Pharm Anal Acta

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“…It can serve as a tool for identification, authentication, qualitative, quantitative analysis and quality control of herbal drug [27]. Thin-layer chromatography (TLC) and HPTLC methods are commonly applied for the identification, assay and testing for purity, stability, dissolution or content uniformity of raw materials (herbal and animal extracts, fermentation mixtures, drugs and excipients) and formulated products (pharmaceuticals, cosmetics, nutriments) [28]. Stigmasterol is reported to show antioxidant [29], antiinflammatory [30], analgesic and anthelmintic [30], hepatoprotective and anticancer activity [31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Identification, Quantification and Validation of Stigmasterol From Alpinia Calcarata Using High-Performance Thin Layer Chromatography Method

Pratheema¹,

Cathrine²

2017

Int J Pharm Pharm Sci

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Objective: The present study is designed to develop a new simple, precise, rapid and selective high-performance thin-layer chromatographic (HPTLC) method for the determination of stigmasterol in methanolic rhizomes extract of Alpinia calcarata. Methods:As per International Conference on Harmonization (ICH) guidelines we have applied different concentrations of stigmasterol as standard on HPTLC plates for the quantification of stigmasterol from the Alpinia calcarata rhizomes. The concentration of standard stigmasterol is 1 mg/ml. Results:The retention factor of stigmasterol was 0.58. Linearity was obtained in the range of 50 ng-250 ng for stigmasterol. The developed and validated HPTLC method was employed for stigmasterol in methanolic rhizomes extract of Alpinia calcarata for standardization of the content of the marker. The linear regression data for the calibration plots showed a good linear relationship with r=0.99977 for stigmasterol, respectively Satisfactory recoveries of 99.77 % were obtained for stigmasterol. Conclusion:The results obtained in validation assays indicate the accuracy and reliability of the developed HPTLC method for the quantification of stigmasterol in methanolic rhizomes extract of Alpinia calcarata

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Analgesic–antiinflammatory properties of Proustia pyrifolia

Cited by 64 publications

References 21 publications

Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease

Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease

Simultaneous Quantification of Bergenin, (+)-Catechin, Gallicin and Gallic acid; and Quantification of β-Sitosterol using HPTLC from Bergenia ciliata (Haw.) Sternb. Forma ligulata Yeo (Pasanbheda)

Identification, Quantification and Validation of Stigmasterol From Alpinia Calcarata Using High-Performance Thin Layer Chromatography Method

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