Analgesic, Antioxidant and Anti-inflammatory Related Activities of 21-hydroxy-2,41-dimethoxychalcone and 4-hydroxychalcone in Mice

Oyedapo, Ololade A.; Adewunmi, C. O.; Iwalewa, E. O.; Makanju, VO

doi:10.3923/jbs.2008.131.136

Cited by 28 publications

(2 citation statements)

References 22 publications

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“…Structurally, chalcones possess 1,3-diaryl-2-propen-1-one moiety in which the two aryl groups are linked together by three carbons (carbonyl and an α , β -unsaturated system) [1]. Chalcones are yellow-coloured compounds having numerous biological activities including cytotoxic [2], anticancer [3], anti-inflammatory, antioxidant, analgesic, antibacterial, antifungal, and antiprotozoal [4]. Chalcones reserves are inexhaustible in all parts of edible plants.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth

Memon

Ismail

Aisha

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Syzygium campanulatum Korth is an equatorial, evergreen, aboriginal shrub of Malaysia. Conventionally it has been used as a stomachic. However, in the currently conducted study dimethyl cardamonin or 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC) was isolated from S. campanulatum Korth, leaf extract. The structural characterization of DMC was carried out by making use of various techniques including UV, IR, NMR spectral followed by LC-MS, and X-ray crystallographic techniques. For determining the purity of compound, highly effective techniques including TLC, HPLC, and melting point were used. The cytotoxicity of DMC and three different extracts of S. campanulatum was evaluated against human colon cancer cell line (HT-29) by three different assays. DMC and ethanolic extract revealed potent and dose-dependent cytotoxic activity on the cancer cell line with IC50 12.6 and 90.1 µg/mL, respectively. Quite astonishingly to our knowledge, this is the very first report on S. campanulatum as being a rich source (3.5%) of DMC, X-ray crystallography, and anticancer activity on human colon cancer cells.

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Section: Introductionmentioning

confidence: 99%

Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth

Memon

Ismail

Aisha

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Inflammation is initiated with the upregulation of enzymes like iNOS and cyclooxygenase-2 (COX-2). Therefore, inhibition of COX pathway of arachidonic acid metabolism which produces prostaglandins is required for anti-inflammatory activity (16) . Besides its role in causing edema and erythema, prostaglandins are known to be hyperalgesic and have vasodilating activity.…”

Section: Discussionmentioning

confidence: 99%

In vivo Evaluation of Ilex khasiana for its Analgesic and Anti-inflammatory Activity on Swiss albino Mice Model

Lalnunfela,

Lalremsanga,

Lalchhandama

et al. 2023

IJST

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Objective: To evaluate the analgesic and anti-inflammatory properties of I. khasiana using selected parameters. Methods: Acetic acid induced writhing test, Tail emersion test and Hot plate test, Xylene induced ear edema, Formalin induced paw edema and Carrageenan induced paw edema were employed for the studies of anti-inflammatory activity of the plant on Swiss albino mice. Findings: In the acetic acid induced abdominal writhing test, the highest percent of inhibition 30.95% was found in 250 mg.kg b.w dose of IKM followed by 25.50% in IKC. In tail emersion test highest analgesic percentage was found at 90 minutes in IKC (250 mg.kg b.w) 68.96, but IKM (250 mg.kg b.w) exhibited the highest inhibition of 50% at 120 minutes. Surprisingly, IKC (500 mg.kg b.w) at 180 minutes gave the highest inhibition percentage of 76.19 but IKM (250 mg.kg b.w) at 180 minutes inhibited 79.36% of the pain which was slightly higher when compared to 60.60% of IKM (500 mg.kg b.w) at the same time point. In xylene induced ear edema test IKM gave 36.84% of inhibition and it was higher than IKC (500 mg/kg b.w) which was found to be 24.73. After 6 hours in formalin induced edema, IKC (250 mg/kg b.w) gave 49.69% of inhibition which was higher than 36.21% inhibition exerted by IKM. In both the paw edema test, at 2 hours after inducing inflammation, the peak was comparatively high and reduced gradually as the time increased. Carrageenan paw edema was measured for 6 hours at hourly intervals. Inhibition of edema increased with time, IKM (250 mg/kg b.w) has a percentage of 36.21% and IKC at the same dose has 28.16% of inhibition. Novelty: Ilex khasiana, the unexplored yet critically endangered species has a scientific support not only with regards to its protection but its enormous contribution in phytochemistry. Conclusion: IKC and IKM showed close efficacy regarding their analgesic and anti-inflammatory activity. Like the other Ilex species, I. khasiana has valuable medicinal property and is demanding special attention being a critically endangered species in terms of propagation https://www.indjst.org/ and protection.

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Antibacterial and antifungal screening of newly synthesized benzimidazole-clubbed chalcone derivatives

Parikh¹,

Joshi²

2012

Med Chem Res

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Analgesic, Antioxidant and Anti-inflammatory Related Activities of 21-hydroxy-2,41-dimethoxychalcone and 4-hydroxychalcone in Mice

Cited by 28 publications

References 22 publications

Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth

Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth

In vivo Evaluation of Ilex khasiana for its Analgesic and Anti-inflammatory Activity on Swiss albino Mice Model

Antibacterial and antifungal screening of newly synthesized benzimidazole-clubbed chalcone derivatives

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