Analgesic, antipyretic, nephritic and antioxidant effects of the aerial parts of Bassia eriophora (Family: Chenopodiaceae) plant on rats

Yusufoğlu, Hasan Soliman

doi:10.1016/s2222-1808(15)60836-2

Cited by 6 publications

(22 citation statements)

References 16 publications

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“…The intermolecular interactions (HB-donor, HB-acceptor, H-π, π-π, π-cation) play a prime role in energetically stabilizing ligands at the binding site of protein receptors. Among all types of molecular interactions, hydrogen bonding represented the predominated type in our in-silico study, though other hydrophobic interactions were also participated, however, hydrogen bond networks assist the binding strength between target receptor and compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), e.g., hydrogen bonds modulate the ligand/receptor binding a nity which is usually a result of setting up of like-for-like synergistic interactions [67].…”

Section: Molecular Docking Resultsmentioning

confidence: 97%

“…Our ndings of the molecular docking are suggestive of B. indica BuOH frac. containing compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) having the ability to affect the target enzyme systems in such a way as co-crystallized ligand and even better, which is an indicative for their potential anthelmintic activity against T. spiralis at different life stages. The ADMET properties as well as drug-likeness of all identi ed compounds were predicted, to stand on the suitable compounds that may be act as a future lead target.…”

Section: Declarationsmentioning

confidence: 99%

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Comprehensive Chemical Profiling of Bassia indica Wight. Aerial Parts Extract Using UPLC-ESI-MS/MS, and Its Antiparasitic Activity in Trichinella spiralis Infected mice: In Silico Supported In Vivo Study

Mohammed

Heikal

Ellessy

et al. 2022

Preprint

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Background Trichinellosis is a public health threat infected both animals and humans as a result of eating undercooked meat. It caused by Trichinella spiralis that has widespread drug resistance and even developed many sophisticated strategies for their survival, this increases the demand in searching for new anthelmintic drugs from natural source. Methods Our objectives were to test the in vitro and in vivo anthelmintic activity of Bassia indica BuOH fraction, and to characterize its chemical composition using UPLC-ESI-MS/MS. Besides an in silico molecular docking study with the prediction of the PreADMET properties. Results In vitro investigation of B. indica BuOH frac., showed severe destruction of the adult worm and larvae, marked cuticle swelling, areas with vesicles, blebs and loss of annulations. This was assured via in vivo study, which revealed a significant reduction (P < 0.05) in the mean adult worm count with efficacy of 47.8% along with a significant decrease (P < 0.001) in the mean larval count per gram muscle with efficacy 80.7%. Histopathological examinations of the small intestine and muscular sections showed marked improvement. In addition, immunohistochemical findings demonstrated that B. indica BuOH frac. depressed the proinflammatory cytokines expressions of TNF-α, which is obviously upregulated by T. spiralis. Precise chemical investigation of the BuOH frac. using UPLC-ESI-MS/MS resulted in the identification of 13 oleanolic type triterpenoid saponins; oleanolic acid 3-O-6´-O-methyl-β-D-glucurono-pyranoside (1), chikusetsusaponin-IVa (2) and its methyl ester (3), chikusetsusaponin IV (4) and its methyl ester (5), momordin-Ic (6) and its methyl ester (7), betavulgaroside-I (8), -II (9) -IV (10), -X (11), licorice-saponin-C2 (12) and -J2 (13). In addition, 6 more phenolics were identified as syringaresinol (14), 3,4-di-O-caffeoylquinic acid (15), 3-O-caffeoyl-4-O-dihydrocaffeoylquinic acid (16), 3,4-di-O-caffeoylquinic acid butyl ester (17), 3,5-di-O-galloyl-4-O-digalloylquinic acid (18) and quercetin 3-O-(6´´-feruloyl)-sophoroside (19). The auspicious anthelmintic activity was further ascertained using in silico molecular docking approach that targeted certain protein receptors (β-tubulin monomer, tumor necrosis factor alpha (TNF-α), cysteine protease (Ts-CF1), calreticulin protein (Ts-CRT)), all the docked compounds (1–19) fit into the binding site of the active pocket with binding affinities noteworthy than albendazole. In addition, ADMET properties, drug score and drug likeness were predicted for all compounds.

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Section: Molecular Docking Resultsmentioning

confidence: 97%

Section: Declarationsmentioning

confidence: 99%

Comprehensive Chemical Profiling of Bassia indica Wight. Aerial Parts Extract Using UPLC-ESI-MS/MS, and Its Antiparasitic Activity in Trichinella spiralis Infected mice: In Silico Supported In Vivo Study

Mohammed

Heikal

Ellessy

et al. 2022

Preprint

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“…The increase in blood glucose level was significantly lowered upon treatment with TME of B. eriophora in a dose-dependent manner. Our observation could be related to the induction of oxidative stress by STZ + HFD [ 48 ], that was potentially abolished by treatment with TME of B. eriophora which was reported to possess an antioxidant property [ 28 ]. According to this report, TME of B. eriophora was found to alleviate oxidative stress in rats’ tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Bassia eriophora ( B. eriophora ) (Family: Chenopodiaceae ) is a plant that grows naturally in the Eastern Province of Saudi Arabia, and is known as gteena [ 25 ]. Documented evidence shows that B. eriophora has been used in folk medicine in the treatment of Alzheimer’s disease, alopecia and gingivitis in Iran [ 26 ], whereas in Saudi Arabia, it is commonly used in the treatment of renal and rheumatic diseases, and its white fibers are used as cotton stuffing [ 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacologically, B. eriophora has been reported to have analgesic, antipyretic, antioxidant, antirheumatic, antimicrobial, anti-inflammatory, wound-healing and protein kinase-inhibitory properties [ 25 , 26 , 27 , 28 , 30 , 31 , 32 ]. Chemical composition of B. eriophora is reported to contain flavonoids: luteolin, acacetin-7- O -β- d -glucoside, diosmin, kaempferol-3- O -rutinoside and rutin [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Chemical Composition, Antihyperglycemic and Antilipidemic Effects of Bassia eriophora and Its Derived Constituent, Umbelliferone on High-Fat Diet and Streptozotocin-Induced Diabetic Rats

et al. 2022

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This study was designed to investigate the chemical profile, antihyperglycemic and antilipidemic effect of total methanolic extract (TME) of Bassia eriophora and isolated pure compound umbelliferone (UFN) in high-fat diet (HFD)- and streptozotocin (STZ)- induced diabetic rats. TME was subjected to various techniques of chromatography to yield UFN. Diabetes was induced after eight weeks of HFD by administration of STZ (40 mg/kg) intraperitoneally, and experimental subjects were divided into five groups. The diabetic control showed an increase in levels of blood glucose throughout the experiment. Treatments were initiated in the other four groups with glibenclamide (GLB) (6 mg/kg), TME (200 mg/kg and 400 mg/kg) and isolated UFN (50 mg/kg) orally. The effect on blood glucose, lipid profile and histology of the pancreatic and adipose tissues was assessed. Both 200 and 400 mg/kg of TME produced a comparably significant decrease in blood glucose levels and an increase in insulin levels with GLB. UFN began to show a better blood sugar-lowering effect after 14 days of treatment, comparatively. However, both 400 mg/kg TME and UFN significantly returned blood glucose levels in diabetic rats compared to normal rats. Analysis of the lipid profile showed that while HFD + STZ increased all lipid profile parameters, TME administration produced a significant decrease in their levels. Histopathological examinations showed that treatment with TME and UFN revealed an improved cellular architecture, with the healthy islets of Langerhans and compact glandular cells for pancreatic cells distinct from damaged cells in non-treated groups. Conversely, the adipose tissue displayed apparently normal polygonal fat cells. Therefore, these results suggest that TME has the potential to ameliorate hyperglycemia conditions and control lipid profiles in HFD + STZ-induced diabetic rats.

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Current knowledge on genus Bassia All.: a comprehensive review on traditional use, phytochemistry, pharmacological activity, and nonmedical applications

et al. 2023

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Bassia All. is a genus from the Amaranthaceae family, which was created by merging selected species belonging to the former Bassia and Kochia genera with those classified to Chenolea, Londesia, Kirilowia and Panderia. The reorganised Bassia genus currently comprises around 20 species, which are annual herbs or perennial subshrubs native to Eurasia and Africa. Bassia plants are well known for their therapeutic applications in folk medicine and traditional medical systems, and they are also used for nonmedical purposes. Some members of this genus, such as Bassia scoparia (syn. Kochia scoparia) is of great medical importance and economic value. The plant is cultivated in some regions of Asia as a crop to collect Kochiae fructus, which is used for both curative and food purposes. Phytochemical studies carried out on Bassia species indicate that these plants synthesize metabolites belonging to different groups of compounds (e.g., triterpene saponins, sterols, flavonoids, fatty acids, lignanamides, alkaloids, organic acids). Some of the structures are rarely found in the plant kingdom. Biological activity studies carried out on Bassia plants revealed various effects exerted by extracts and isolated compounds, including anti-inflammatory, cytotoxic, antioxidant, antimicrobial, hypoglycemic, anti-obesity, etc. Modern research explained some of the mechanisms of action. This review covers literature from 1935 to 2022, and assembles and discusses data on phytochemistry, biological activity, as well as medical and nonmedical use of the representatives of the genus Bassia. In this review we present the current state of knowledge about the plants of the genus.

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Analgesic, antipyretic, nephritic and antioxidant effects of the aerial parts of Bassia eriophora (Family: Chenopodiaceae) plant on rats

Cited by 6 publications

References 16 publications

Comprehensive Chemical Profiling of Bassia indica Wight. Aerial Parts Extract Using UPLC-ESI-MS/MS, and Its Antiparasitic Activity in Trichinella spiralis Infected mice: In Silico Supported In Vivo Study

Comprehensive Chemical Profiling of Bassia indica Wight. Aerial Parts Extract Using UPLC-ESI-MS/MS, and Its Antiparasitic Activity in Trichinella spiralis Infected mice: In Silico Supported In Vivo Study

Investigation of the Chemical Composition, Antihyperglycemic and Antilipidemic Effects of Bassia eriophora and Its Derived Constituent, Umbelliferone on High-Fat Diet and Streptozotocin-Induced Diabetic Rats

Current knowledge on genus Bassia All.: a comprehensive review on traditional use, phytochemistry, pharmacological activity, and nonmedical applications

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