Analgesic Comparison of Meloxicam or Ketoprofen for Orthopedic Surgery in Dogs

Deneuche, Aymeric; Dufayet, Cédric; Goby, L.; Fayolle, P.; Desbois, Christophe

doi:10.1111/j.1532-950x.2004.04088.x

Cited by 53 publications

(40 citation statements)

References 50 publications

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“…Many of the non-steroidal anti-inflammatory drugs (NSAIDs) have proven to be effective in controlling post-operative pain in dogs when used either alone or in combination with opioids [3,5,8,10,11,13]. However, the administration of NSAIDs may induce gastrointestinal toxicity, compromise renal blood flow, and/or cause hemostatic abnormalities as the results of inhibition of cyclo-oxygenase (COX).…”

mentioning

confidence: 99%

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Kondo¹,

Takashima²,

Matsumoto³

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator's judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.

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confidence: 99%

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Kondo¹,

Takashima²,

Matsumoto³

et al. 2012

The Journal of Veterinary Medical Science

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“…This effect on hemostasis also creates a surgical handicap by increasing the chances of intraoperative bleeding (6,24). Some writers reported, however, that this defect has no clinical relevance (6,26). In human medicine, dexketoprofen is considered as an excellent analgesic (22).…”

Section: Tab 2 Blood Chemistry Values In the Control (N=7) And Dexkmentioning

confidence: 99%

Evaluation of preemptive dexketoprofen trometamol effect on blood chemistry, vital signs and postoperative pain in dogs undergoing ovariohysterectomy

Saritas¹,

Sarıtaş²,

Pamuk³

et al. 2015

BLL

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Abstract:Objective: To investigate the postoperative analgesic effects of preemptive dexketoprofen trometamol in dogs subjected to ovariohysterectomy (OHE). Material and methods: Seventeen adult bitches of various breeds were used in this study. The dogs were randomly allocated into of two groups. Subjects in the dexketoprofen trometamol (DEX) group (n = 10), received intravenous (i.v.) dexketoprofen trometamol, 1 mg/kg, 15 minutes before premedication, while those assigned to the control (C) group (n = 7) were given no analgesics prior to premedication. Pain level was assessed by two researchers before the administration of anaesthesia (15 minutes before start) and 0, 1, 2, 4 and 6 hours after surgery. A modifi ed University of Melbourne Pain Scale (UMPS) was used to evaluate pain in both groups. Results: Serum cortisol level changed from 0 to 1 h and from 0 to 1 to 4 h were compared between the groups; the increase in the C group was statistically signifi cant. The modifi ed UMPS was applied to both groups at baseline and postoperative 1, 2, 4 and 6 h. According to this test, the values for DEX were signifi cantly lower than controls at 4 and 6 h (p < 0.001). Conclusion: Stable vital signs with unchanged biochemical parameters on dexketoprofen administration are a promising fi nding. The clinical advantage shown by the pain scale difference and the low serum cortisol levels should qualify dexketoprofen for preemptive pain management in dogs (Tab. 5, Fig. 2, Ref. 30). Text in PDF www.elis.sk.

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“…In addition, local anesthetics have been reported to interact with mu and kappa opioid receptors 34 , potentiating the analgesic effect mediated by opioid drugs 39 .…”

Section: Variablementioning

confidence: 99%

Analgesic comparison of systemic lidocaine, morphine or lidocaine plus morphine infusion in dogs undergoing fracture repair

et al. 2014

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Intellectual and scientific content of the study, statistical analysis, critical revision. ABSTRACT PURPOSE:To compare the postoperative analgesic effects of lidocaine, morphine and lidocaine plus morphine administered by constant rate infusion (CRI) and analyzing their effects on opioid requirements after orthopedic surgery in dogs. METHODS:Twenty-four dogs underwent fracture repairs were premedicated with IM acepromazine (0.05 mg/kg) combined with morphine (0.3mg/kg). Anesthesia was induced with IV propofol (4 to 5 mg/ kg) and maintained with isoflurane. The dogs were randomly assigned to 3 groups and administered a CRI IV of lidocaine (T-L), morphine (T-M) or lidocaine plus morphine (T-LM) at the same doses. Postoperative analgesia was assessed for 24 hours using a Visual Analog Scale (VAS) and the Glasgow Composite Pain Scale (GCPS). Rescue analgesia was performed if the evaluation score exceeded 50% of the VAS and/or 33% of the GCPS. RESULTS:The pain score and postoperative opioid requirements did not differ among the treatments. Rescue analgesia was administered to 1/8 dogs in the T-M and T-LM, and to 3/8 dogs in the T-L. CONCLUSION:Lidocaine, morphine or lidocaine/morphine CRI may be efficacious techniques for pain management in the first 24 hours post-surgery. However, the two drugs administered together did not reduce the postoperative opioid requirement in dogs undergoing fracture repair.

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Analgesic Comparison of Meloxicam or Ketoprofen for Orthopedic Surgery in Dogs

Cited by 53 publications

References 50 publications

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Evaluation of preemptive dexketoprofen trometamol effect on blood chemistry, vital signs and postoperative pain in dogs undergoing ovariohysterectomy

Analgesic comparison of systemic lidocaine, morphine or lidocaine plus morphine infusion in dogs undergoing fracture repair

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