2019
DOI: 10.33314/jnhrc.v16i41.1647
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Analgesic Effect of Caudal Bupivacaine with or without Clonidine in Pediatric Patient

Abstract: Background: Caudal analgesia has long been the cornerstone to successful pain management in children undergoing abdominal and lower limb surgeries. Its analgesic duration with single shot injection is however limited. So adjuvants are used with local anesthetics in an attempt to increase the duration of caudal analgesia. This study aims to investigate the duration of analgesia provided by Clonidine when added to caudal Bupivacaine.Methods: A randomized, double blinded, comparative study was conducted on 64 pat… Show more

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Cited by 5 publications
(3 citation statements)
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“…Clonidine is a high blood pressure medication that can affect the alpha-adrenergic receptors and imidazoline as an agonist [ 54 ]. A critical theory about the effect mechanisms of clonidine in pain management describes that many pain signals are generated in the dorsal horn of the spinal cord and then sent to the central nervous system.…”
Section: Discussionmentioning
confidence: 99%
“…Clonidine is a high blood pressure medication that can affect the alpha-adrenergic receptors and imidazoline as an agonist [ 54 ]. A critical theory about the effect mechanisms of clonidine in pain management describes that many pain signals are generated in the dorsal horn of the spinal cord and then sent to the central nervous system.…”
Section: Discussionmentioning
confidence: 99%
“…15 Single-shot caudal block, which once used to be very popular, is now losing its popularity in clinical practice due to its relative shorter duration of action, for which several additive drugs are now being used to enhance the Bupivacaine caudal block analgesia duration. 16 Caudal block is also associated with local and systemic side effects, including ascending meningitis, arrhythmias, hypotension, seizures, puncture site infection, osteomyelitis of sacral bone, block failure, and local nerve root injury. 17 Splinter et al, performed a study to compare the effect of local anaesthesia with caudal anaesthesia on post-operative care of children undergoing inguinal hernia repair.…”
Section: Discussionmentioning
confidence: 99%
“…Ketamine, Fentanyl, and Clonidine mixed with caudal LA have been studied for prolonging postoperative analgesia in children. 1,5,6 Despite efficacy, opioids including Fentanyl and Morphine are not universally accepted owing to their higher association with itching, vomiting, and hypoventilation. 1,7,8 Dexmedetomidine, a newer alpha-2 adrenergic receptor agonist that possesses a better receptor selectivity when compared to Clonidine, is shown to prolong the action of caudal LA.…”
Section: Introductionmentioning
confidence: 99%