Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor

Tian, Shuxin; Xu, Ting; Shi, Renyi; Cai, Yang-Qian; Wu, Minghui; Zhen, Si-jia; Wang, Wen; Du, Junying; Fang, Jiaqi; Shao, Xiaomei; Liu, Boyi; Jiang, Yongliang; He, Xiaofen; Fang, Jianqiao; Liang, Yi

doi:10.1007/s11302-022-09861-7

Cited by 11 publications

(8 citation statements)

References 51 publications

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“…[18] EA ameliorated MRMT-1-induced mechanical abnormal pain and thermal nociceptive hyperalgesia in a rat model of bone cancer pain (BCP), and exerted analgesic effects on BCP by reducing P2X3R overexpression and functional activity in the ipsilateral dorsal root ganglia of BCP rats. [19] The above experiments further support EA as a potential treatment option for clinical cancer pain. In addition, EA inhibited chemotherapy induced pains through activation of spinal 5-HT 1A receptors and suppression of p-CaMKII.…”

Section: Intervention Methodsmentioning

confidence: 62%

Global research trends in acupuncture for cancer pain: A bibliometric analysis

Yang,

Liang,

Xue

et al. 2023

Medicine

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Background: In recent years, acupuncture has gained popularity in the management of cancer-related pain (CRP). This study aims to use bibliometric analysis to investigate the historical development, recent hotspots and research trends in this field. Methods: The Web of Science Core Collection database was selected as the data source for this study to retrieve and obtain literature related to acupuncture and CRP. Data analyses were performed with CiteSpace and VOSviewer to conduct the bibliometric analysis. Results: This bibliometric analysis was conducted from 2000 to 2022. A total of 664 publications were included in this work. The number of publications has steadily increased over the last 2 decades. The United States has the largest number of published articles (244 papers), while the People’s Republic of China has the highest centrality (0.48). The primary research institutions were Memorial Sloan-Kettering Cancer Center, Kyung Hee University and Beijing University of Chinese Medicine. Mao Jun J. was the most prolific author, while Heather Greenlee was the most cited one. The most productive journal was Integrative Cancer Therapies. The most frequent keywords excluding the search subject were “electroacupuncture,” “management,” “quality of life,” “breast cancer,” “Aromatase inhibitor,” “neuropathic pain,” “mechanisms,” and “protocol.” Conclusion: This study explored the application value of acupuncture in the management of CRP with bibliometric analysis, offering an intuitive understanding of this topic and revealing the hotspots and research trends.

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Section: Intervention Methodsmentioning

confidence: 62%

Global research trends in acupuncture for cancer pain: A bibliometric analysis

Yang,

Liang,

Xue

et al. 2023

Medicine

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“…As for immunology pathways, in a study of a rat model of prostate cancer bone metastases, electroacupuncture was found to inhibit pro-inflammatory cytokines, such as IL-1β, which attenuate nociceptive receptor sensitivity and inhibit pain transmission ( 40 ). Electroacupuncture can also directly downregulate the expression of nociceptive receptors in a rat model of cancer pain, such as P2X3 receptors in the dorsal root ganglion of rats ( 41 ). Electroacupuncture can modulate immune cells, such as macrophages ( 42 ), mast cells ( 43 ) and T cells ( 44 ), to reduce pain-causing substances produced by inflammation and tissue injury.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture for the treatment of cancer pain: a systematic review and meta-analysis of randomized clinical trials

Zhang

Ren

et al. 2023

Front. Pain Res.

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ObjectiveThis paper aims to review the current evidence on electroacupuncture as an effective and safe therapy for cancer pain management.MethodsFive databases were searched from their inception through November 11, 2022. Only the randomized controlled trials that meet the eligibility criteria were finally included in the study. Literature screening and data extraction were performed independently by two reviewers, and RevMan 5.3 used for meta-analysis.ResultsA total of 17 RCTs met our inclusion criteria. We used 8 indicators to estimate the meta-analysis results, most of which proved statistically significant, including VAS scores, NRS scores, and KPS scores. To be specific, VAS scores (MD = −1.41, 95% CI: −2.42 to −0.41, P = 0.006) and NRS scores (MD = −1.19, 95% CI: −1.72 to −0.66, P < 0.0001) were significantly lower in the treatment group compared to the control group. The treatment group's KPS scores (MD = 5.48, 95% CI: 3.27 to 7.69, P < 0.00001) were higher than those of the control group. Also, in the treatment group, the number of burst pain (MD = −2.66, 95% CI: −3.32 to −1.99, P < 0.00001) and side effect rates (RR = 0.51, 95% CI: 0.39 to 0.67, P < 0.00001) greatly reduced, while the response rate (RR = 1.17, 95% CI: 1.09 to 1.26, P < 0.0001) significantly increased compared to the control group.ConclusionThis study demonstrates the advantages of electroacupuncture in the treatment of cancer pain. Meanwhile, rigorous RCTs should be designed and conducted in the future to further demonstrate the exact efficacy of electroacupuncture.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022376148.

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“…P2X3R was found to be distributed not only in the peripheral nervous system but also in the presynaptic portion of the spinal cord and in the periaqueductal gray matter (PAG) of the midbrain. Tian Shuxin et al showed that both peripheral and central P2X3Rs are involved in analgesia [ 46 ]. Moreover, Liu Min reported that the functional upregulation of P2X3R is involved in the pathogenesis of pain, as well as the fact that P2X3 receptors are involved in injurious transmission and modulation in the peripheral and central nervous system and that P2X3R blocks mechanically abnormal pain and nociceptive hyperalgesia, thus exerting a significant analgesic effect [ 47 ].…”

Section: Modulation Of Fd/mas Pain By Purinergic Receptors (P2xrs)mentioning

confidence: 99%

“…2018 Falk et al [49] Animal experiments on rats The P2X7R ion channel is expressed during OC (osteoclast) maturation, and it mediates inflammatory vesicle activation and IL-1β① release, which is needed for OC-mediated bone loss; it also mediates reduced mechanosensitivity of osteocytes P2X7R may be a potential pharmacological target for the treatment of MAS and could lead us to further investigate the role of this receptor in the progression of bone remodeling pain 2023 Sun et al [50] Overview P2X4 receptors mediate neuropathic pain in spinal cord injury and are significantly involved in mediating the pain hypersensitivity response to increased BDNF and p38-MAPK ② P2X4R and P2X7R may be trigger molecules in exercise-mediated changes in BDNF③ and provide a possible mechanism for MAS pain protection 2022 Yuan et al [47] Animal experiments on rats Pharmacological blockade of P2X3R has a significant analgesic effect on mechanical abnormal pain and thermal nociceptive sensitization It may serve as an important target for blocking pain during MAS 2023 Tian et al [46] Animal experiments on rats P2X3R is involved in analgesia, and P2X3R is distributed not only in the peripheral nervous system (such as primary afferent central terminals) but also in the presynaptic portion of the spinal cord and in the periaqueductal gray matter (PAG) of the midbrain conductors MAS pain process can be treated by blocking P2X3R as an important method of pain treatment Wang and Jiang Journal of Orthopaedic Surgery and Research (2024) 19:196 Table 4 Summary of studies on potential targeting mechanisms of brain-derived neurotrophic factor (BDNF) family receptors for bone pain ① GDNF/GFRα: GFRα is a high-affinity receptor for GDNF; ② NGF/TrkA: nerve growth factor (NGF)/promyosin receptor kinase A (TrKA) signaling axis; ③ Glial cell line-derived neurotrophic factor receptor α3…”

Section: Main Conclusionmentioning

confidence: 99%

Recent research advances in pain mechanisms in McCune–Albright syndrome thinking about the pain mechanism of FD/MAS

Wang,

Jiang

2024

J Orthop Surg Res

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Background The lack of effective understanding of the pain mechanism of McCune–Albright syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address this dilemma. Objective This paper summarizes the novel mechanisms, targets, and treatments that may produce pain in MAS and fibrous dysplasia (polyfibrous dysplasia, or FD). Methods We conducted a systematic search in the PubMed database, Web of Science, China Knowledge Network (CNKI) with the following keywords: “McCune–Albright syndrome (MAS); polyfibrous dysplasia (FD); bone pain; bone remodeling; G protein coupled receptors; GDNF family receptors; purinergic receptors and glycogen synthase kinase”, as well as other keywords were systematically searched. Papers published between January 2018 and May 2023 were selected for finding. Initial screening was performed by reading the titles and abstracts, and available literature was screened against the inclusion and exclusion criteria. Results In this review, we systematically analyzed the cutting-edge advances in this disease, synthesized the findings, and discussed the differences. With regard to the complete mechanistic understanding of the pain condition in FD/MAS, in particular, we collated new findings on new pathways, neurotrophic factor receptors, purinergic receptors, interferon-stimulating factors, potassium channels, protein kinases, and corresponding hormonal modulation and their respective strengths and weaknesses. Conclusion This paper focuses on basic research to explore FD/MAS pain mechanisms. New nonneuronal and molecular mechanisms, mechanically loaded responsive neurons, and new targets for potential clinical interventions are future research directions, and a large number of animal experiments, tissue engineering techniques, and clinical trials are still needed to verify the effectiveness of the targets in the future.

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Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor

Cited by 11 publications

References 51 publications

Global research trends in acupuncture for cancer pain: A bibliometric analysis

Global research trends in acupuncture for cancer pain: A bibliometric analysis

Electroacupuncture for the treatment of cancer pain: a systematic review and meta-analysis of randomized clinical trials

Recent research advances in pain mechanisms in McCune–Albright syndrome thinking about the pain mechanism of FD/MAS

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