Analgesic Effect of Lidocaine Patch 5% in the Treatment of Acute Herpes Zoster: A Double-Blind and Vehicle-Controlled Study

Lin, Pei-Lin; Fan, Shou-Zen; Huang, Chi‐Hsiang; Huang, Hui-Hsun; Tsai, Ming-Cheng; Lin, Chun-Chih; Sun, Wei‐Zen

doi:10.1016/j.rapm.2007.02.015

Cited by 29 publications

(25 citation statements)

References 18 publications

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“…A randomized controlled trial has shown that the lidocaine patch can provide significant pain relief in acute HZ but care should to taken to ensure that it is applied only to the area of intact skin. 24, 55 Topical capsaicin is an effective backup alternative in the treatment of PHN. 31 Unfortunately, most patients find the burning sensation from capsaicin intolerable so it is not recommended for acute pain from HZ.…”

Section: Treatmentmentioning

confidence: 99%

Herpes Zoster in the Older Adult

John

Canaday

2017

Infectious Disease Clinics of North America

140

101

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Synopsis Herpes Zoster (HZ) is the result of reactivation of latent varicella zoster virus (VZV) and occurs most frequently in older adults. Generally, HZ presents as a unilateral, self-limited dermatomal rash. Postherpetic neuralgia (PHN) is a common sequela; presenting as severe pain that persists after the rash has resolved. It occurs more commonly in older age and can be very debilitating. Management of HZ in the elderly requires a prompt diagnosis, treatment with antivirals, and adequate pain control. A longer- term pain management strategy is required if PHN occurs. A modestly effective vaccine exists and is recommended for older individuals.

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Section: Treatmentmentioning

confidence: 99%

Herpes Zoster in the Older Adult

John

Canaday

2017

Infectious Disease Clinics of North America

140

101

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“…Data are limited on the effectiveness of ketamine and amitriptyline, 54-59 but the evidence for the effectiveness of lidocaine and capsaicin is stronger. 54,56-58 In a randomized trial of 35 patients with non–cancer-related postherpetic, postoperative, or diabetes-related neuropathic pain, pain intensity was reduced with topical lidocaine but not with topical amitriptyline when compared with placebo. 57 A larger trial with a similar population of 92 patients found no effect of topical amitriptyline, ketamine, or a combination of the two.…”

Section: Management Of Painmentioning

confidence: 99%

Survivorship: Pain Version 1.2014

Denlinger¹,

Ligibel²,

Are³

et al. 2014

J Natl Compr Canc Netw

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“…Lidocaine (LID), an amide derivative, is a safer anaesthetic agent that possesses a mild local analgesic effect (10). The efficacy of combinatorial FLB and LID therapy has already been established for the propofol injection induced pain (11).…”

mentioning

confidence: 99%

Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain

et al. 2016

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Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental painA novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (HPMC) and sodium alginate (SA). The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, swellability index and in vitro release of active agents.Release of both drugs depended on the relative ratio of HPMC:SA. However, mucoadhesive strength and mucoadhesion time were better in formulations, containing higher proportions of HPMC compared to SA. An artificial neural network (ANN) approach was applied to optimise formulations based on known effective parameters (i.e., mucoadhesive strength, mucoadhesion time and drug release), which proved valuable. This study indicates that an effective buccal tablet formulation of flurbiprofen and lidocaine can be prepared via an optimized ANN approach.Keywords: dental pain, mucoadhesion time, mucoadhesive strength, buccal tablet, artificial neural network Dental pathologies/disorders are usually associated with inflammation and moderate to severe pain (1). These are managed using analgesics alone or in combination with a variety of other drugs, e.g., antibiotics, local anaesthetics, non-steroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors (2, 3). Among analgesics, opioids and NSAIDs are commonly used to control acute dental pain. Opioids work by blocking nociceptors and are considered superior to NSAIDs. However, due to adverse drug reactions and psychological adherence, opioids require professional supervision, which restricts their use (4). NSAIDs, at higher doses, are usually considered the drugs of choice in dental pain (5). Among NSAIDs, flurbiprofen (FLB), a propionic acid derivative, is a drug used to treat acute pain associated with dental pathology (6, 7). For FLB, the recommended maximum daily dose is 300 mg; however, a single dose of 100 mg can be effective in treating dental pain (8).

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Analgesic Effect of Lidocaine Patch 5% in the Treatment of Acute Herpes Zoster: A Double-Blind and Vehicle-Controlled Study

Abstract: This study demonstrates that lidocaine patch 5%, applied twice a day, could serve as a well tolerated and effective modality to relieve moderate to severe pain associated with acute herpes zoster presumably through its pharmacological action and physical barrier effect on sensitized skin.

Cited by 29 publications

References 18 publications

Herpes Zoster in the Older Adult

Herpes Zoster in the Older Adult

Survivorship: Pain Version 1.2014

Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain

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