Analgesic effect of topical oral capsaicin gel in burning mouth syndrome

Abstract

Topical capsaicin might be an alternative for the short-term treatment of BMS. However, further studies are needed to investigate especially the gastro-intestinal side-effects which may limit its long-term use.

Pharmacological treatment of oro‐facial pain – health technology assessment including a systematic review with network meta‐analysis

“…Sixteen studies had high risk of bias (Figure ) and were excluded from analysis (Table ). The remaining 41 studies rated as medium or low risk of bias were included in the qualitative analysis for the individual groups: 15 studies on patients classified as TMD‐joint , nine on patients classified as TMD‐muscle and 17 on patients with BMS .…”

World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials

“…In this systematic review, nearly 75% of the RCTs used an existing BMS definition to guide case selection (Cavalcanti & da Silveira, ; Femiano, ; Femiano & Scully, ; Gremeau‐Richard, Dubray, Aublet‐Cuvelier, Ughetto, & Woda, ; Gremeau‐Richard et al., ; Lopez‐Jornet, Camacho‐Alonso, & Andujar‐Mateos, ; Marino, Torretta, Capaccio, Pignataro, & Spadari, ; Petruzzi, Lauritano, De Benedittis, Baldoni, & Serpico, ; Sardella et al., , ; Spanemberg, Lopez Lopez, de Figueiredo, Cherubini, & Salum, ; Spanemberg et al., ), most commonly that by IASP (Cano‐Carrillo, Pons‐Fuster, & Lopez‐Jornet, ; Cavalcanti & da Silveira, ; Gremeau‐Richard et al., ; Jorgensen & Pedersen, ; Lopez‐Jornet et al., ; Marino et al., ; Palacios‐Sánchez, Moreno‐Lopez, Cerero‐Lapiedra, Llamas‐Martinez, & Esparza‐Gomez, ; Sardella et al., ; Silva, Siqueira, Teixeira, & Siqueira, ; Spanemberg et al., ; Umezaki et al., ) or IHS (Arduino et al., ; Carbone, Pentenero, Carrozzo, Ippolito, & Gandolfo, ; Jurisic Kvesic et al., ; Lopez‐Jornet, Camacho‐Alonso, & Leon‐Espinosa, ; López‐Jornet, Camacho‐Alonso, & Molino‐Pagan, ; Tammiala‐Salonen & Forssell, ; Valenzuela & Lopez‐Jornet, ; Valenzuela, Pons‐Fuster, & Lopez‐Jornet, ). However, the most current BMS definition by IASP and IHS differs (IASP, ; IHS, ).…”

“…In this systematic review, nearly 75% of the RCTs used an existing BMS definition to guide case selection (Cavalcanti & (Jorgensen & Pedersen, 2017;Silva et al, 2014) IHS (2004) Continuous symptoms of oral burning or pain on a daily or almost daily basis, during all or part of the day for more than 6 months 8 studies (Tammiala-Salonen & Forssell, 1999*;Lopez-Jornet et al, 2009;Marino et al, 2010;Lopez-Jornet et al, 2011;Cano-Carrillo et al, 2014;Spanemberg et al, 2012;Jurisic Kvesic et al, 2015;Valenzuela et al, 2016) IHS (2013) Continuous symptoms of oral burning or pain on a daily or almost daily basis during all or part of the day for more than 6 months and the absence of local or systemic factors that could produce the same symptoms 3 studies (Arduino et al, 2016;López-Jornet et al, 2013;Valenzuela & Lopez-Jornet, 2017) Other definitions -Daily bilateral oral burning (or pain-like sensation) and pain that is experienced deep within the oral mucosa, unremitting for at least 4-6 months, continuous throughout all or almost all day, seldom interferes with sleep, and never worsens, but may be relieved, by eating and drinking -All forms of burning sensation in the mouth, including complaints described as stinging sensation or pain, in association with an oral mucosa that appears clinically normal in the absence of local or systemic diseases or alterations -Burning sensation of the tongue or other oral tissues in the absence of local lesions -Continuous oral burning pain for more than 2 or 4 months with no clinical signs that could justify the syndrome -Continuous symptoms of pain more than 4 months continuous throughout all or part of the day with no paroxysms -Symptoms of burning or pain/discomfort in the oral mucosa for at least 6 months and who presented a clinically normal mucosa -Constant burning discomfort in the tongue, lower lip, or hard palate, for more than 2 months, with no relevant drug or medical history without clinical mucosal lesions or alterations in laboratory parameters 13 studies (Carbone et al, 2009;Cavalcanti & da Silveira, 2009;Femiano & Scully, 2002;Gremeau-Richard et al, 2004Palacios-Sánchez et al, 2015;Petruzzi et al, 2004;Sa...…”

“…-Fuster, & Lopez-Jornet, 2014;Cavalcanti & da Silveira, 2009;Gremeau-Richard et al, 2004;Jorgensen & Pedersen, 2017;Lopez- Jornet et al, 2011;Marino et al, 2010;Palacios-Sánchez, Moreno-Lopez, Cerero-Lapiedra, Llamas-Martinez, & Esparza-Gomez, 2015;Sardella et al, 2008;Silva, Siqueira, Teixeira, & Siqueira, 2014;Spanemberg et al, 2012;Umezaki et al, 2016) or IHS (Arduino et al, 2016; Carbone, Pentenero, Carrozzo, Ippolito, & Gandolfo, 2009; Jurisic Kvesic et al, 2015; Lopez-Jornet, Camacho-Alonso, & Leon-Espinosa, 2009; López-Jornet, Camacho-Alonso, & Molino-Pagan, 2013; Tammiala-Salonen & Forssell, 1999; Valenzuela & Lopez-Jornet, 2017; Valenzuela, Pons-Fuster, & Lopez-Jornet, 2016). However, the most current BMS definition by IASP and IHS differs(IASP, 2016; IHS, 2018).…”

Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge

“…The symptoms usually involve the tongue, lips and the anterior part of the palate (Headache Classification Committee of the International Headache Society (IHS), ). Additional prominent symptoms include xerostomia and taste disturbances, especially dysgeusia (Forssell et al, ; Grushka, ; Jørgensen & Pedersen, ).…”