Analgesic effect of vibration and cooling on pain induced by intraneural electrical stimulation

Bini, Giorgio; Cruccu, G.; Hagbarth, K. E.; Schady, W.; Torebjörk, Erik

doi:10.1016/0304-3959(84)90819-4

Cited by 126 publications

(67 citation statements)

References 15 publications

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“…The ability of dynamic contact to inhibit LTN sites together with evidence that both nonpainful cold and tactile stimulation can inhibit pain (Pertovaara 1979;Bini et al 1984;Craig and Bushnell 1994), suggests that low-threshold stimulation of the nociceptive pathway can be readily inhibited. Convincing evidence that stimulation from cold fibers inhibits cold-induced nociceptive stimulation comes from the aforementioned studies of ischemic or pressure block of A-δ cold fibers, which causes innocuous cooling to be felt as stinging, burning or hot (Fruhstorfer 1984;Kojo and Pertovaara 1986;Wahren et al 1989;Yarnitsky and Ochoa 1990).…”

Section: Discussionmentioning

confidence: 99%

Nociceptive sensations evoked from ‘spots’ in the skin by mild cooling and heating

Green

Roman

Schoen

et al. 2008

Pain

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It was recently found that nociceptive sensations (stinging, pricking, or burning) can be evoked by cooling or heating the skin to innocuous temperatures (e.g., 29°, 37°C). Here we show that this lowthreshold thermal nociception (LTN) can be traced to sensitive 'spots' in the skin equivalent to classically defined warm spots and cold spots. Because earlier work had shown that LTN is inhibited by simply touching a thermode to the skin, a spatial search procedure was devised that minimized tactile stimulation by sliding small thermodes (16 mm 2 and 1 mm 2 ) set to 28° or 36°C slowly across the lubricated skin of the forearm. The procedure uncovered three types of temperature-sensitive sites (thermal, bimodal and nociceptive) that contained one or more thermal, nociceptive or (rarely) bimodal spots. Repeated testing indicated that bimodal and nociceptive sites were less stable over time than thermal sites, and that mechanical contact differentially inhibited nociceptive sensations. Intensity ratings collected over a range of temperatures showed that LTN increased monotonically on heat-sensitive sites but not on cold-sensitive sites. These results provide psychophysical evidence that stimulation from primary afferent fibers with thresholds in the range of warm fibers and cold fibers is relayed to the pain pathway. However, the labile nature of LTN implies that these lowthreshold nociceptive inputs are subject to inhibitory controls. The implications of these findings for the roles of putative temperature receptors and nociceptors in innocuous thermoreception and thermal pain are discussed.

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Section: Discussionmentioning

confidence: 99%

Nociceptive sensations evoked from ‘spots’ in the skin by mild cooling and heating

Green

Roman

Schoen

et al. 2008

Pain

View full text Add to dashboard Cite

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“…As has been shown by several authors [8,13,18,29,36], peripheral activation of mechanoreceptive afferents inhibit activity in pain-transmitting pathways in the dorsal horn of the spinal cord and its medullary equivalent. The idea that a central mechanism is in fact operating in pain alleviation by vibration in experimental pain has also been put forward by Bini et al [4], based on the results of mic rostimulation experiments in man.…”

Section: Discussionmentioning

confidence: 99%

Influence of Stimulus Frequency and Probe Size on Vibration-Induced Alleviation of Acute Orof acial Pain

Hansson

Ekblom²

1986

Stereotact Funct Neurosurg

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The pain-relieving effect of vibratory stimulation, using different stimulus parameters, and placebo stimulation in acute orofacial pain is reported. The influence of 10-, 100-, and 200-Hz vibrations on pain reduction was studied in 96 patients; two different probe sizes were used. 54 out of 76 patients, receiving vibrations at any of the above frequencies, reported relief of pain to some extent, while only 6 out of 20 patients receiving placebo treatment experienced pain alleviation. No significant differences were found between the different frequencies and probe sizes used regarding the pain-relieving effect. However, placebo stimulation was significantly less effective than any kind of vibratory stimulation. Induction time for pain relief was significantly shorter using the larger probe as compared to using the smaller probe, regardless of frequency. The results indicate that the vibratory frequency (10–200 Hz) for activation of pain-inhibitory mechanisms is not critical in acute orofacial pain. Also, spatial summation from vibration-sensitive afferents seems to be of importance for a fast activation of the inhibitory systems.

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“…It is a well-known phenomenon that pain, particularly heat pain, is inhibited by cold and that cold ambient temperature facilitates antinociceptive behavior (Bini et al 1984;Osgood et al 1990). On the other hand, touching warm and cool bars that are spatially interlaced produces a painful burning sensation resembling that caused by intense noxious cold (the thermal grill illusion).…”

Section: Thalamo-cortical Thermoreceptive and Nociceptive Pathwaysmentioning

confidence: 99%

Role of afferent pathways of heat and cold in body temperature regulation

et al. 2004

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The detection of surface and internal temperatures is achieved by axons terminating at lamina I of the spinal dorsal horn, otherwise approached only by nociceptive afferents. Recent advances in thermal physiology research have disclosed that temperature-sensitive ion channels belonging to the "transient receptor potential" family exist in the peripheral sensory neurons and in the brain. Thermosensory, nociceptive and polymodal afferents project to different thalamic nuclei, and specific pathways to the insular cortex evoke the conscious experience of thermal sensation. The posterior insular region represents discriminative thermal sensation, while the largest correlation with subjective ratings of temperature is located in the orbitofrontal and anterior insular cortex. The insular cortex forms an integrative part of the limbic system and is closely tied with the hypothalamus, the amygdala, the anterior cingulate cortex and the orbitofrontal cortex and emerges as the main coordinator of behavioral, autonomic and endocrine responses to both non-noxious and noxious thermal stimuli. The firing rate of warm and cold receptors is not altered by pyrogens. A strong correlation between the onset of fever and production of superoxide by macrophages following the injection of pyrogens implicates reactive oxygen species as elicitors of fever, a hypothesis strengthened by the observation that oxygen radical scavengers or thiol reductants act as antipyretics. Oxidative stress appears to be sensed by the brain and a likely structure for its detection may be the redox-sensitive site of the N-methyl-D-aspartate (NMDA) receptor for glutamate, in that oxidation of this site causes fever while its reduction lowers body temperature, effects which are abrogated by specific NMDA receptor blockers.

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Analgesic effect of vibration and cooling on pain induced by intraneural electrical stimulation

Cited by 126 publications

References 15 publications

Nociceptive sensations evoked from ‘spots’ in the skin by mild cooling and heating

Nociceptive sensations evoked from ‘spots’ in the skin by mild cooling and heating

Influence of Stimulus Frequency and Probe Size on Vibration-Induced Alleviation of Acute Orof acial Pain

Role of afferent pathways of heat and cold in body temperature regulation

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