Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models

Woode, Eric; Ameyaw, Elvis Ofori; Boakye‐Gyasi, Eric; Abotsi, Wonder Kofi Mensah

doi:10.4103/0975-7406.103251

Cited by 70 publications

(69 citation statements)

References 49 publications

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“…They serve as a (Adu-Amoah et al, 2014) and the use of Myrianthus arboreus and Alchornea cordifolia for treating wounds and other infections in Ghana .There have also been reports on the use of Hilleria latifolia as an antinociceptive agent (Woode and Abotsi, 2011). The analgesic and anti-inflammatory activities of Xylopia aethiopica have been reported (Woode et al, 2012) and Phyllanthus muellerianus has been reported to possess anti-inflammatory activities (Boakye et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

In vitro activity of selected Ghanaian medicinal plants against parasites: Giardia lamblia, Entamoeba histolytica and Naegleria fowleri

Kyere-Davies¹,

Agyare²,

Boakye³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Entamoeba histolytica and Giardia lamblia are parasitic protozoa that cause gastrointestinal disorders such as diarrhea and dysentery. Naegleria fowleri is a free living amoeba that causes primary amoebic meningoencephalitis. However, there are limited treatments for these parasitic diseases. Extracts, fractions from extracts and some isolated compounds from selected Ghanaian medicinal plants were screened against Naegleria fowleri, Giardia lamblia and Entamoeba histolytica in the search for newer and safer agents for the treatment of infections caused by these parasites. Of all the extracts and compounds tested for the activity against E. histolytica, only xylopic acid and geraniin were active with

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Section: Introductionmentioning

confidence: 99%

In vitro activity of selected Ghanaian medicinal plants against parasites: Giardia lamblia, Entamoeba histolytica and Naegleria fowleri

Kyere-Davies¹,

Agyare²,

Boakye³

et al. 2017

Afr. J. Pharm. Pharmacol.

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“…The effect of pretreatment of rats with EthE on prostaglandin E 2 -induced hypernociception was evaluated as earlier described (Vale et al 2004;Woode et al 2012). Six groups of rats (n ¼ 5) received pretreatment with either vehicle (10 mL/kg, p.o.)…”

Section: Prostaglandin E 2 (Pge 2 )-Induced Hypernociceptionmentioning

confidence: 99%

“…To evaluate the effect of EthE pretreatment on mechanical hypernociception induced by bradykinin in rats, a previously described method was used (Vale et al 2004;Woode et al 2012). Five groups of rats (n ¼ 5) were pretreated with either EthE (30, 100 and 300 mg/kg, p.o., 1 h) or morphine (3 mg/kg, i.p., 30 min) before intraplantar injection of bradykinin (500 ng/paw; 20 lL) into their right hind paws.…”

Section: Bradykinin-induced Hypernociceptionmentioning

confidence: 99%

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Possible mechanisms involved in the anti-nociceptive effects of hydro-ethanolic leaf extract of Ziziphus abyssinica

Boakye‐Gyasi

Henneh

Abotsi

et al. 2017

Pharmaceutical Biology

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Context: Various parts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) have been used in Ghanaian and African traditional medicine as an analgesic. However, there are little scientific data to support the anti-nociceptive effects of the hydro-ethanolic leaf extract of Ziziphus abyssinica (EthE) as well as the possible mechanisms involved in its anti-nociceptive effects. Purpose: To predict possible nociceptive pathways involved in the anti-nociceptive effects of EthE. Materials and methods: The effect of EthE (30, 100 and 300 mg/kg) on intraplantar injection of pain mediators such as interleukin-1b, tumour necrosis factor-a, prostaglandin E 2 and bradykinin was evaluated in male Sprague Dawley rats using Randall-Selitto test for 5 h. The effect of specific antagonists to the opioidergic, adenosinergic, ATP-sensitive K þ channels, nitric oxide, serotonergic, muscarinic, adrenergic and voltage-gated calcium channel on the anti-nociceptive effect of EthE (100 mg/kg) was evaluated using the formalin test in male imprinting control region (ICR) mice for 1 h. Results: Pretreatment of the rats with EthE significantly reversed the hypernociception induced by intraplantar injection of TNF-a (F 4,120 ¼ 10.86, p < 0.0001), IL-1b (F 4,120 ¼ 14.71, p < 0.0001), bradykinin (F 4,80 ¼ 12.52, p < 0.0001) and prostaglandin E 2 (F 5,144 ¼ 6.165, p ¼ 0.0001). The anti-nociceptive effect exhibited by EthE in the formalin test was reversed by systemic administration of N G -L-nitro-arginine methyl ester, naloxone, theophylline and glibenclamide. Conclusions: EthE inhibits hypernociception induced by TNF-a, IL-1b, bradykinin and prostaglandin E 2 . EthE exhibited anti-nociceptive effects possibly mediated through opioidergic, adenosinergic, ATP-sensitive potassium channels and nitric oxide cyclic GMP pathways. ARTICLE HISTORY

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“…In another study unpublished, we demonstrated that Xylopia aethiopica dried fruit extract caused alteration in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and glucocorticoid hormone during proestrus phase of clomiphene-treated rats. Because Xylopia aethiopica have analgesic properties and can be used in the management of pain disorders similar to ibuprofen [4,22], therefore, the present study compared the inhibiting effects of ibuprofen and Xylopia aethiopica dried fruit extracts on the serum levels of FSH, LH, glucocorticoid, estrogen and progesterone in order to determine the contraceptive potential of Xylopia aethiopica dried fruit extract independent of the estrous cycle in adult female Wistar rats. …”

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confidence: 99%

A Comparative Study between Xylopia aethiopica Dried Fruit Extract and Ibuprofen Inhibiting Effects on Some Reproductive Hormones Irrespective of the Estrous Cycle

Onuka

Okechukwu

Maxine

2017

IJCAM

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Ibuprofen is often used for contraception, therefore, Xylopia aethiopica dried fruit extract and ibuprofen were tested on follicle-stimulating hormone (FSH), luteinizing hormone (LH), glucocorticoid, progesterone and estrogen levels in adult female rats in order to determine whether Xylopia aethiopica dried fruit extract can be used for contraception. Twenty one rats were randomly divided into 3 groups (n = 7) comprising of control group A, experimental Group B and C. The experimental Group B received 180 mg/kg of ibuprofen daily and experimental Group C received 300 mg/kg of Xylopia aethiopica dried fruit extract. All administration of drug and extract was done via oral route and lasted for 14 days independent of estrous cycle. Using Enzyme-linked Immunosorbent Assay the serum FSH, LH, glucocorticoid, progesterone and estrogen in both extract and ibuprofen treated rats were measured. Results showed that ibuprofen caused significant reduction of FSH (P<0.05). The extract did not cause significant difference in the serum FSH level. Both ibuprofen and extract caused significant reduction (P<0.05) in the serum LH levels. Both ibuprofen and extract caused significant elevation (P< 0.05) in glucocorticoid level. However, the extract caused significant reduction (P<0.05) in the serum progesterone and estrogen levels respectively compared to ibuprofen. In that sense, Xylopia aethiopica dried fruit extract acted as a more potent contraceptive, inhibitor of ovulatory hormones than ibuprofen. and selectively blocks estrogen-mediated receptors in rats [7]. Moreover, the use of synthetic steroidal contraceptives has proven unsafe to the health of the user as they pose risk of side effects [8][9][10]. Keywords:In Africa, traditional methods of contraception are on the increase and have been increasingly sought for in herbal plants because herbs are effective, cheap and safe [11] [16,17]. Meanwhile, in ancient times, women drank extracted water from Xylopia aethiopica as a natural method of contraception that became part of Igbo folklore and this led to the present research work. The plant, Xylopia aethiopica commonly known as "Uda" in Igbo language, "Eeru alamo" in Yoruba language and "Chimba" in Hausa language is a tropical evergreen, aromatic plant that grows commonly in wet swampy soils and forest zones of West Africa characterized with a slim tall tree of about 15 -30 m tall and 0.6 -0.7 m in diameter, straight stem, slightly stripped or smooth bark with consistent pepperish aroma with dry brown, corrugated in shape with pods containing 4 -9 kidney shaped peppery seeds about 0.05 m in length [18,19].However, antifertility effect of Xylopia aethiopica have been demonstrated in male rats [20,21]. In another study unpublished, we demonstrated that Xylopia aethiopica dried fruit extract caused alteration in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and glucocorticoid hormone during proestrus phase of clomiphene-treated rats. Because Xylopia aethiopica have analgesic properties and can be used in t...

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Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models

Cited by 70 publications

References 49 publications

In vitro activity of selected Ghanaian medicinal plants against parasites: Giardia lamblia, Entamoeba histolytica and Naegleria fowleri

In vitro activity of selected Ghanaian medicinal plants against parasites: Giardia lamblia, Entamoeba histolytica and Naegleria fowleri

Possible mechanisms involved in the anti-nociceptive effects of hydro-ethanolic leaf extract of Ziziphus abyssinica

A Comparative Study between Xylopia aethiopica Dried Fruit Extract and Ibuprofen Inhibiting Effects on Some Reproductive Hormones Irrespective of the Estrous Cycle

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