2010
DOI: 10.1016/j.joms.2009.04.049
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Analgesic Effects of Intra-Articular Morphine in Patients With Temporomandibular Joint Disorders: A Prospective, Double-Blind, Placebo-Controlled Clinical Trial

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Cited by 26 publications
(23 citation statements)
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“…Opioid receptor systems in peripheral sensory neurons are also capable of assuming a second, nonresponsive state that is refractory to reactivation as a consequence of a LOX-dependent AA metabolite. This complex, dual regulation of peripheral opioid receptor function may underlie some of the variability in efficacy of peripherally restricted opioids seen in clinical trials for the treatment of pain (Dionne et al, 2001;Gupta et al, 2001;Likar et al, 2001;Stein et al, 2003;Solheim et al, 2006;Ziegler et al, 2010). A better understanding of the mechanisms by which the function of peripheral opioid receptors can be regulated may lead to improved and safer approaches for the treatment of pain.…”
Section: Arachidonic Acid Regulation Of D-opioid Receptor Functionmentioning
confidence: 99%
“…Opioid receptor systems in peripheral sensory neurons are also capable of assuming a second, nonresponsive state that is refractory to reactivation as a consequence of a LOX-dependent AA metabolite. This complex, dual regulation of peripheral opioid receptor function may underlie some of the variability in efficacy of peripherally restricted opioids seen in clinical trials for the treatment of pain (Dionne et al, 2001;Gupta et al, 2001;Likar et al, 2001;Stein et al, 2003;Solheim et al, 2006;Ziegler et al, 2010). A better understanding of the mechanisms by which the function of peripheral opioid receptors can be regulated may lead to improved and safer approaches for the treatment of pain.…”
Section: Arachidonic Acid Regulation Of D-opioid Receptor Functionmentioning
confidence: 99%
“…Analgesic effect of peripheral opioid receptor is known more effective when inflammatory state but, in none inflammatory knee joint surgery morphine administration has an analgesic effect. [54][55][56] In the study of Ziegler et al 10) analgesic effect of intra-articular morphine in patients with temporomandibular joint disorders, morphine 10mg had the longest and prominent analgesic effect. From this study they had an analgesic effect on non inflammatory patient so they concluded sufficient dose of morphine could more effective on inflammatory patients.…”
Section: Objective Pain Evaluation Resultsmentioning
confidence: 99%
“…8) There are studies of applying opioid when oral surgery so it can reduce post operation pain, 9) and 5 mg, 10 mg morphine sulfate were applied in TMJ due to reduce pain. 10) As a result, this study was designed to evaluate the pain control effect by morphine sulfate injection to masticatory muscle pain patients.…”
mentioning
confidence: 99%
“…Ziegler et.al. 15 reported that using morphine with local anaesthesia (bupivacaine) led to decrease in pain during and after the operation in their patients. Tuz et.al.…”
Section: Discussionmentioning
confidence: 99%