Analgesic Effects of Intraarticular Sufentanil and Sufentanil Plus Methylprednisolone After Arthroscopic Knee Surgery

Abstract

The combined use of intraarticular sufentanil (10 microg) and methylprednisolone (40 mg) in arthroscopic meniscectomy surgery reduced both postoperative pain scores and the use of additional analgesics.

Efficacy and Safety of Steroid Use for Postoperative Pain Relief

“…Kizilkaya et al 80 (level I) reported that administration of sufentanil with methylprednisolone in the knee joint after arthroscopic meniscectomy reduced pain (p < 0.05) and the use of analgesics (p < 0.05) significantly compared with administration of sufentanil alone and reduced it even more com-pared with administration of saline solution (p < 0.05). A similar study conducted by Rasmussen et al 81 (level I) showed that the addition of methylprednisolone to the analgesia regimen further reduced pain, joint swelling, the duration of immobilization, and the need for rescue analgesics (p < 0.05).…”

Comparisons of analgesic effects of different doses of morphine and morphine plus methylprednisolone after knee surgery

“…Results of studies concerning postoperative analgesic effects of intra-articular administration of opioids are confusing [4][5][6]. Combination therapy by using an opioid plus a non-opioid drug has been proposed for alleviating postoperative pain [7,8].…”

“…Combination therapy by using an opioid plus a non-opioid drug has been proposed for alleviating postoperative pain [7,8]. Intra-articular glucocorticoid may also improve pain relief after arthroscopy possibly due to its effect on reducing inflammation [6,9].…”

“…; and Group M1M (n ϭ 19) received 1 mg morphine plus 40 mg methylprednisolone in 20 mL of isotonic saline intraarticularly and 5 mL of isotonic saline i.v. The doses of drugs were chosen on the basis of previous clinical studies [6,8,10]. The test drugs were given to the surgeon who injected the solution through the arthroscope at the end of the procedure without knowing the contents so as to ensure that the drug was delivered into the joint.…”

A Randomized, Prospective, Double-Blind Study to Investigate the Effectiveness of Adding DepoMedrol to a Local Anesthetic Injection in Postmeniscectomy Patients With Osteoarthritis of the Knee

“…2 Administration after diagnostic arthroscopy or meniscectomy is noted to decrease postoperative pain scores, consumption of analgesics, and recovery time. 14,20,21 The cohort of patients with existing OA undergoing meniscectomy is potentially at higher risk of further joint degeneration and poor symptomatic outcomes, as the relative contribution of OA to the patient's symptoms may exceed that which is due to the meniscal injury. Postoperative corticosteroid injection may alleviate postoperative discomfort and improve the outcomes in this at-risk population.…”