Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis

Ferreira‐Gomes, Joana; Adães, Sara; Mendonça, Marcelo; Castro-Lopes, José Manuel

doi:10.1016/j.pbb.2012.03.003

Cited by 46 publications

(49 citation statements)

References 25 publications

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“…In the current study, morphine significantly reversed the unrestricted hind limb WB deficit 1 hour post-administration compared to vehicle-injected OA rats (P < 0.05). The efficacy of morphine in this OA model is in accordance with previous studies [11,15,27] where similar doses of morphine had anti-nociceptive effects demonstrated by WB changes. In a human study, morphine was efficacious in reducing pain in patients with moderate-to-severe OA [28].…”

Section: Morphinesupporting

confidence: 91%

“…The maximum antinociceptive effect of morphine sulfate has been determined to occur between 30 and 90 minutes when dosed at 6 mg/kg [27]. In the current study, morphine significantly reversed the unrestricted hind limb WB deficit 1 hour post-administration compared to vehicle-injected OA rats (P < 0.05).…”

Section: Morphinesupporting

confidence: 50%

“…Morphine is widely used in animal models investigating OA-related joint pain [11,[14][15]27]. The maximum antinociceptive effect of morphine sulfate has been determined to occur between 30 and 90 minutes when dosed at 6 mg/kg [27].…”

Section: Morphinementioning

confidence: 99%

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Unrestricted Weight Bearing as a Method for Assessment of Nociceptive Behavior in a Model of Tibiofemoral Osteoarthritis in Rats

Gregersen¹,

Røsland²,

Arendt-Nielsen³

et al. 2013

JBBS

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Background: Novel preclinical models for prediction of osteoarthritis-like pain are necessary for the elucidation of osteoarthritis (OA) pathology and for assessment of novel analgesics. A widely used behavioral test in rat models of tibiofemoral OA is hind limb weight bearing (WB). However, this method evaluates WB in an unnaturally restricted manner. The aim of this study was therefore to characterize the Tekscan Pressure Measurement System as a means to assess OA-like tibiofemoral pain in rats by determination of plantar pressure distribution in a more natural and unrestricted position, defined as unrestricted WB. Methods: Intra-articular injections of 1 mg monosodium iodoacetate (MIA) or saline were administrated in the left hind knee of 84 male Sprague Dawley rats. Changes in unrestricted WB between ipsilateral and contralateral hindlimbs were determined. Morphine (5 mg/kg administered subcutaneously) and naproxen (60 mg/kg per-oral) were examined for their ability to reverse WB changes. Results: Changes in hind limb unrestricted WB were observed 14 (P < 0.05), 21 (P < 0.001) and 28 (P < 0.001) days post intra-articular injections of MIA compared to control. These alterations were attenuated by morphine 1 hour post administration compared to baseline but were not affected by naproxen. Conclusion: This study indicated that unrestricted WB assessed by the Tekscan system can be utilized as a clinically relevant method to assess aberrations in WB induced by intra-articular MIA injections in rodents. Therefore, this system may be useful for understanding the mechanisms of OA pain in humans and may also assist in the discovery of novel pharmacological agents.

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Section: Morphinesupporting

confidence: 91%

Section: Morphinesupporting

confidence: 50%

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Unrestricted Weight Bearing as a Method for Assessment of Nociceptive Behavior in a Model of Tibiofemoral Osteoarthritis in Rats

Gregersen¹,

Røsland²,

Arendt-Nielsen³

et al. 2013

JBBS

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“…Vehicle administration had no effect in both tests (data not shown, previously published in Ref. 7,31). Gabapentin had no sedative effect as determined by the normal exploratory behaviour in the CatWalk test.…”

Section: Pharmacological Evaluationsupporting

confidence: 54%

Injury of primary afferent neurons may contribute to osteoarthritis induced pain: an experimental study using the collagenase model in rats

Adães

Ferreira‐Gomes

Mendonça

et al. 2015

Osteoarthritis and Cartilage

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“…In general, NSAIDs have ameliorative effects on weight bearing asymmetry during the early phase after MIA injection, in which prominent inflammation develops, but limited efficacy in late stages of the disease [53,59,60,73,74] (Table 1 ). This is in agreement with human studies showing that osteoarthritis pain is resistant to NSAIDs [75,76].…”

Section: Measuring Functional Disability In Rodents: Adaptive Posturamentioning

confidence: 99%

“Bedside-to-Bench” Behavioral Outcomes in Animal Models of Pain: Beyond the Evaluation of Reflexes

Cobos

Portillo‐Salido

2013

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Despite the myriad promising new targets and candidate analgesics recently identified in preclinical pain studies, little translation to novel pain medications has been generated. The pain phenotype in humans involves complex behavioral alterations, including changes in daily living activities and psychological disturbances. These behavioral changes are not reflected by the outcome measures traditionally used in rodents for preclinical pain testing, which are based on reflexes evoked by sensory stimuli of different types (mechanical, thermal or chemical). These measures do not evaluate the impact of the pain experience on the global behavior or disability of the animals, and therefore only consider a limited aspect of the pain phenotype. The development of relevant new outcomes indicative of pain to increase the validity of animal models of pain has been increasingly pursued over the past few years. The aim has been to translate “bedside-to-bench” outcomes from the human pain phenotype to rodents, in order to complement traditional pain outcomes by providing a closer and more realistic measure of clinical pain in rodents. This review summarizes and discusses the most important nonstandard outcomes for pain assessment in preclinical studies. The advantages and drawbacks of these techniques are considered, and their potential impact on the validation of potential analgesics is evaluated.

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Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis

Cited by 46 publications

References 25 publications

Unrestricted Weight Bearing as a Method for Assessment of Nociceptive Behavior in a Model of Tibiofemoral Osteoarthritis in Rats

Unrestricted Weight Bearing as a Method for Assessment of Nociceptive Behavior in a Model of Tibiofemoral Osteoarthritis in Rats

Injury of primary afferent neurons may contribute to osteoarthritis induced pain: an experimental study using the collagenase model in rats

“Bedside-to-Bench” Behavioral Outcomes in Animal Models of Pain: Beyond the Evaluation of Reflexes

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