Analgesic effects of naringenin in rats with spinal nerve ligation-induced neuropathic pain

Hu, Chuan Yin; Zhao, Yun-Tao

doi:10.3892/br.2014.267

Cited by 33 publications

(16 citation statements)

References 18 publications

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“…The present study indicated that NAR inhibited microglia activation-mediated neuroinflammation. These results were consistent with the previous studies that NAR alleviated neuropathic pain through inhibiting microglia-induced neuroinflammation (Hu and Zhao, 2014).…”

Section: Discussionsupporting

confidence: 94%

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

Zhang

Wei

Wang

et al. 2019

Front. Cell. Neurosci.

107

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Neuroinflammation is considered to be an important and inevitable pathological process associated with all types of damages to, and disorders of, the central nervous system. The hallmark of neuroinflammation is the microglia activation. In response to different micro-environmental disturbances, microglia could polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype, exerting neuroprotection. Therefore, shifting the polarization of microglia toward the M2 phenotype could possess a more viable strategy for the neuroinflammatory disorders treatment. Naringenin (NAR) is naturally a grapefruit flavonoid and possesses various kinds of pharmacological activities, such as anti-inflammatory and neuroprotective activities. In the present study, we aimed to investigate the potential effects of NAR on microglial M1/M2 polarization and further reveal the underlying mechanisms of actions. First, NAR inhibited lipopolysaccharide (LPS)-induced microglial activation. Then, NAR shifted the M1 pro-inflammatory microglia phenotype to the M2 anti-inflammatory M2 microglia state as demonstrated by the decreased expression of M1 markers (i.e., inducible TNF-α and IL-1β) and the elevated expression of M2 markers (i.e., arginase 1, IL-4, and IL-10). In addition, the effects of NAR on microglial polarization were dependent on MAPK signaling, particularly JNK inactivation, as evidenced by the fact that the selective activator of JNK abolished NAR-promoted M2 polarization and further NAR-inhibited microglial activation. Together, this study demonstrated that NAR promoted microglia M1/M2 polarization, thus conferring anti-neuroinflammatory effects via the inhibition of MAPK signaling activation. These findings might provide new alternative avenues for neuroinflammation-related disorders treatment.

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Section: Discussionsupporting

confidence: 94%

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

Zhang

Wei

Wang

et al. 2019

Front. Cell. Neurosci.

107

View full text Add to dashboard Cite

show abstract

“…Other than in citrus fruits, naringenin also contain in honey. Study reports naringenin to have analgesic effect in inhibiting neuropathic pain on rats (Kaulaskar et al, 2012;Hu and Zhao, 2014). The result also demonstrates that narigenin reduced lipid peroxidation and nitric oxide.…”

Section: Analgesic Effects Of Honey and Potentials In Morphine Tolerance Studymentioning

confidence: 79%

Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance

Zakaria¹,

Ahmad²,

Hashim³

et al. 2015

J App Pharm Sci

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“…Glial activation leads to a pro-inflammatory response with pathological effects, such as neuronal hyperexcitability, chronic neurotoxicity, and inflammation, which improves neuropathic healing. 24 Abnormal activation of microglia produces a primary cellular response that plays an essential role in the pathogenesis of the inflammatory response. 15,18 Specific cytokines released during the inflammatory process play an important role in the development of two modalities of hyperalgesia (thermal and mechanical), so that maintenance of inflammation plays an important role in chronic healing.…”

Section: Pathogenesis Of Inflammatory Pain In Hnpmentioning

confidence: 99%

Potential of Anthocyanin Based Poly (Methyl Methacrylate) Nanoparticles Specific Activated Microglia in Management Inflammatory Pain on Herniated Nucleus Pulposus: A Literature Review

Widyadharma

Satyarsa

Sanjaya

et al. 2021

MNJ

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Pain is an unpleasant sensory and emotional experience that can affect the quality of life and leads to decreased productivity in patients. Low back pain (LBP) is one of the significant causes of disability worldwide with lifelong incidence. The purpose of this literature review describes the potential of anthocyanin-based Poly (Methyl Methacrylate) (PMMA) nanoparticles as the management of inflammatory pain in the Hernia Nucleus Pulposus (HNP ). The method used is a literature study by entering the keyword. Of the 77 journals reviewed, 47 journals were found by the topic and used as a reference for this work. The anthocyanin-based PMMA nanoparticles act as anti-nociceptors by inhibiting microglia that produce inflammatory mediators in HNP. Poly (Methyl Methacrylate) nanoparticles have specific targets in microglia. Anthocyanins have the effect of inhibiting inflammatory pain through many destinations. Anthocyanin inhibits the synthesis of nitric oxide (NO ) and prostaglandin E2 (PGE 2) and inhibits the activation of p38 MAPK and NF-kB pathways that express TNF-α and IL-1β genes as anti-nociceptive. The anthocyanin-based PMMA nanoparticles have potential as a novel therapy for inflammatory pain in HNP. There has been no research between these modalities. Therefore, further research is needed to find out the exact potential of anthocyanin-based PMMA nanoparticles.

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Analgesic effects of naringenin in rats with spinal nerve ligation-induced neuropathic pain

Cited by 33 publications

References 18 publications

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance

Potential of Anthocyanin Based Poly (Methyl Methacrylate) Nanoparticles Specific Activated Microglia in Management Inflammatory Pain on Herniated Nucleus Pulposus: A Literature Review

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