2021
DOI: 10.32598/ijt.15.4.708.3
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Analgesic Effects of the Cressa Cretica Extract on Induced Neuropathic Pain in Rats, and the Potential Role of Opioid Receptors

Abstract: Background: Damages to the peripheral fibers of sensory nerve cells and central neurons cause neuropathic pain. Manifestations of neuropathic pain occur in various conditions, including diabetes mellitus, chemotherapy, and as the side effects of some medications. Cressa cretica has long been used in traditional medicine for pain control. This study was conducted to determine the role of opioid receptors in the analgesic effect of the hydroalcoholic extract of C. cretica in an experimental model of neuropathic … Show more

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Cited by 2 publications
(2 citation statements)
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“…An example of a microvascular complication of diabetes is diabetic neuropathy, a significant cause of disability, diabetic foot ulcer, and amputation in hospitals. Diabetic peripheral neuropathy (DPN) accounts for about 75% of diabetic neuropathy, with pain being its most common symptom (Selvarajah and Tesfaye, 2012;Zheng et al, 2017).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…An example of a microvascular complication of diabetes is diabetic neuropathy, a significant cause of disability, diabetic foot ulcer, and amputation in hospitals. Diabetic peripheral neuropathy (DPN) accounts for about 75% of diabetic neuropathy, with pain being its most common symptom (Selvarajah and Tesfaye, 2012;Zheng et al, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…However, there is evidence that hyperglycemia is crucial in initiating and accelerating the course of diabetes mellitus and diabetic neuropathy. In the nervous system, uncontrolled hyperglycemia targets both the axon (due to its access to the blood supply of the nerve) and the Schwann cells that cover it, thereby destroying axonal integrity and damaging the peripheral fibers of sensory nerve cells leading to pain (Edwards and Vincent, 2008;Zabihi et al, 2021). Hyperglycemia causes a rise in the metabolic activities of the mitochondria and initiates oxidative stress by overwhelming the normal endogenous antioxidants like glutathione, catalase, and superoxide dismutase (SOD) (Prabodha et al, 2018).…”
Section: Introductionmentioning
confidence: 99%