Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection*

Mimoz, Olivier; Incagnoli, Pascal; Josse, Claire; Mc, Gillon; Kuhlman, L; Mirand, A; Soilleux, H.; Fletcher, Dominique

doi:10.1046/j.1365-2044.2001.01980.x

Cited by 134 publications

(130 citation statements)

References 19 publications

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“…5 Studies have consistently demonstrated a 30-40% decrease in postoperative opioid consumption when nefopam is used following abdominal or orthopaedic surgery. 6,7 Unlike nonsteroidal anti-inflammatory drugs, nefopam has no effect on platelet function, 8 and (in contrast to opioids) does not increase the risk of respiratory depression. 9 In addition, nefopam has been shown to result in decreased morphine consumption when used as a coanalgesic following abdominal surgery.…”

Section: Introductionmentioning

confidence: 99%

“…This is in contrast with others who reported that sweating was more common in patients given nefopam than propacetemol or morphine. 7 All patients in the present study were admitted to the ICU following surgery and some were infused with inotropic agents or vasopressors, according to need. As these sympathomimetic drugs can mask the effects of nefopam, 23 the vital signs, respiratory effort and hepatorenal functions of every patient in the present study were closely observed while they were in the ICU.…”

mentioning

confidence: 99%

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The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study

Kim

Choi

et al. 2014

J Int Med Res

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Objective: The efficacy and side-effects of nefopam were prospectively compared with those of fentanyl for patient-controlled analgesia (PCA) following cardiac surgery. Methods: Patients scheduled to undergo cardiac surgery were randomly assigned between three PCA groups (nefopam, fentanyl or nefopam þ fentanyl). Pain was assessed at rest and during movement at 12, 24, 36, 48 and 72 h after surgery using a visual analogue scale (VAS). Total infused PCA volume, number of rescue drug injections, duration of intubation and length of stay in the intensive care unit were recorded. The incidence of adverse effects was noted at 48 h postoperatively. Results: There were no significant between-group differences in VAS score, total PCA infusion volume or number of rescue injections (n ¼ 92 per group). Nausea was significantly more common in the fentanyl group compared with both other groups. Conclusions: PCA with nefopam alone provides suitable postoperative analgesia after cardiac surgery.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study

Kim

Choi

et al. 2014

J Int Med Res

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“…Thus, it is necessary to seek alternatives. Nefopam is a centrally acting non-opioid analgesic (Piercey and Schroeder 1981;Durrieu et al 2007) that has been mainly used to treat cancer pain, visceral smooth muscle cramps and postoperative pain (Mimoz et al 2001). Nefopam has a particularly good effect on reducing postoperative chronic pain and improving postoperative pain management (Laboureyras et al 2009).…”

mentioning

confidence: 99%

Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

Zhang¹,

Li²,

Luan³

et al. 2017

Vet. Med. - Czech

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Relieving perioperative pain can reduce postoperative suffering and improve recovery from anaesthesia in animals. The aim of this study was to compare the analgesic effects of nefopam and tramadol in dogs undergoing ovariohysterectomy. Twenty-four adult mixed-breed female dogs were randomly divided into three groups (n = 8) and received their respective treatments immediately after surgery: Group T (2 mg/kg tramadol, i.v.), Group C (1 mg/kg nefopam, i.v.) and Group D (2 mg/kg nefopam, i.v.). The heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR) and rectal temperature (RT) were measured and the level of analgesia was assessed using the Glasgow Composite Measure Pain Scale (CMPS-SF). The CMPS-SF was performed at least two days before premedication (baseline), every 2 h for the first 8 h (post-extubation), at 12 h and at 24 h. Results showed that the HR in all groups was significantly (P < 0.05) higher at 2 and 6 h than at baseline. The RR in Group T was significantly higher (P < 0.05) at 0 and 2 h than at baseline. Rescue analgesia (0.2 mg/kg morphine, i.v.) was provided if CMPS-SF pain scores greater than or equal to six. Four dogs required rescue analgesia: one dog in Group T at 2 h and three dogs in Group C at 2 and 6 h. No dogs in Group D required rescue analgesia. The CMPS-SF pain scores of dogs in Group C were significantly higher (P < 0.05) than those in Group T at 6, 8 and 12 h. The scores in Group D were significantly lower (P < 0.05) than those in Group C at 2, 4, 6, 8 and 12 h. The scores in Group D were significantly lower (P < 0.05) than those in Group T at 2 and 4 h. However, the scores in Group D were not significantly different compared with Group T. In conclusion, this study suggests that nefopam at 2 mg/kg i.v. produces better postoperative analgesia compared with tramadol at 2 mg/kg i.v. or nefopam at 1 mg/kg i.v. in dogs undergoing ovariohysterectomy.

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“…На сегодняшний день не существует общепри нятого и безопасного алгоритма анестезиологиче ского пособия для ведения пациентов с ЦП [21]. Ре комендуют тщательное титрование лекарственных средств как для анестезии, так и для периопераци онного обез боливания.…”

Section: клиническая проблемаunclassified

The assessment of the probability for the surgical treatment of colorectal cancer with concomitant liver cirrhosis

Iuldashev¹,

Киселева²,

Zhizhko³

et al. 2014

Dok. gastroenterol.

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Внепеченочные хирургические вмешательства у пациентов с циррозом печени ограничивает значительная частота осложнений и летальности. Современные изменения в периоперационном ведении пациентов, использование адаптированных шкал для оценки операционного риска, изменение хирургической техники позволили улучшить результаты лечения и расширить его возможности при многих заболеваниях. Рак толстой и прямой кишки занимает лидирующее положение в структуре онкологической патологии, и хирургия остается основным способом лечения этих заболеваний. Оценка периоперационных рисков у такой сложной категории пациентов позволяет проводить радикальное онкологически обоснованное лечение, которое ранее было им малодоступно. Ключевые слова: цирроз печени, колоректальный рак, аденокарцинома толстой кишки, осложнения, онкология, осложнения цирроза печени.Extrahepatic surgery on the patients presenting with liver cirrhosis has limitations attributable to the high frequency of postoperative complications and lethality. The possibilities for the surgical treatment of extrahepatic pathologies have recently been extended and its outcomes improved by virtue of novel approaches to the perioperative management, the use of adapted scales for the evaluation of the surgical risks, and modification of the operative techniques. Colorectal cancer prevails in the structure of onclological diseases of the gastrointestinal tract and the surgical intervention remains the main method for the management of the patients with this pathology. The adequate assessment of the perioperative risks for such patients creates the prerequisites for the well-substantiated surgical treatment that has recently been unavailable to them.

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Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection*

Cited by 134 publications

References 19 publications

The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study

The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study

Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

The assessment of the probability for the surgical treatment of colorectal cancer with concomitant liver cirrhosis

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