Analgesic Efficacy of Controlled‐Release Oxycodone in Postoperative Pain

Abstract

The efficacy and safety of graded doses (10, 20, and 30 mg) of controlled-release (CR) oxycodone was compared with that of immediate-release (IR) oxycodone (15 mg), immediate-release oxycodone 10 mg in combination with acetaminophen 650 mg (APAP), and placebo in a single-dose, double-blind, randomized, parallel-group study. The participants, 182 inpatients experiencing moderate to severe pain after abdominal or gynecologic surgery, provided hourly ratings of pain intensity and relief for 12 hours after administration. All active treatments were significantly superior to placebo for many hourly measurements and for the sum of pain intensity differences (SPID) and total pain relief (TOTPAR). A dose response was found among the three levels of CR oxycodone for pain relief and peak pain intensity difference (PID), with the 20- and 30-mg doses being significantly better than the 10-mg dose. For all active treatments, peak PID and peak pain relief occurred approximately 2 to 4 hours after administration. The median time to onset of relief was 32 minutes for oxycodone plus APAP, 41 minutes for IR oxycodone, and 46 minutes for CR oxycodone 30 mg. Duration of pain relief showed that the 10-, 20-, and 30-mg doses of CR oxycodone had durations of action of 10 to 12 hours compared with IR oxycodone and oxycodone plus APAP (both approximately 7 hours). Typical adverse events, particularly somnolence, occurred in all active treatment groups. Treatment with CR oxycodone was safe and effective in this study, and its characteristics will be beneficial in the treatment of pain.

Preoperative administration of controlled-release oxycodone as a transition opioid for total intravenous anaesthesia in pain control after laparoscopic cholecystectomy

“…In contrast with these results, Jokela et al [12] have recently shown that premedication with controlledrelease oxycodone does not improve management of postoperative pain after day-case gynecological laparoscopic surgery. Controlled-release oxycodone has shown high bioavailability, which contributes to modest interindividual variability after oral administration [13]. Moreover, the controlled-release formulation improves patient compliance when compared with immediate-release oxycodone [9], as it needs to be taken rarely, only twice or three times a day.…”

Clinical Equivalence of Controlled-Release Oxycodone 20 mg and Controlled-Release Tramadol 200 mg after Surgery for Breast Cancer

“…Predictable pharmacokinetics, rapid onset of action, no ceiling dose, and minimal adverse effects contributed to its successful use in the treatment of postoperative pain [5][6][7][8] . A low incidence of nausea and vomiting compared to other opioids was found in some studies [9,10] , with controlled-release oxycodone causing fewer adverse events than immediate-release oxycodone [3,7,11] .…”

Early oral analgesia after fast-track cardiac anesthesia

“…We observed that the commonly reported opioid side effects 6,[31][32][33][34] were present with both regimens, namely, somnolence, dizziness, pruritus, nausea and vomiting. Respiratory depression, one of the most concerning side effects of opioid medications, was not observed in either group, nor were there any acetaminophen-related side effects, including hepatotoxicity.…”