Introduction: Proper prescription opioid disposal is essential to prevent poisonings and deaths. This study examined the opioid disposal practices of Princess Margaret Cancer Centre Outpatient Palliative Care Clinic (OPCC) patients. Methods: This cross-sectional study involved a retrospective chart review of new, adult patients who were seen in the OPCC (September 2018 -August 2019) and completed a survey about opioid use.Results: 58/111 (52.3%) of study participants did not routinely dispose of their opioids.Cannabis and neuropathic medication use (OR 3.0, 95% CI 1.2 -7.2) were positively associated with routine disposal of opioids. Patients were less likely to routinely dispose of their opioid if they responded "Yes" to "Have you had to increase the amount of opioids you take over the past six months?" (OR 0.38; 95% CI, 0.16 -0.88).iii Conclusion: There is a high prevalence of people with life-limiting illnesses who do not routinely dispose of their opioids.