Analgesic properties of the GABA-minetic thip

Hill, Ronald C.; Maurer, Richard A.; Buescher, H. H.; Roemer, D.

doi:10.1016/0014-2999(81)90419-2

Cited by 130 publications

(27 citation statements)

References 6 publications

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“…The antinociceptive effect of systemically administered baclofen has been well documented in rodents (Cutting & Jordan, 1975;Levy & Proudfit, 1977;Bartolini et al, 1981;Hill et al, 1981;Sawynok & La Bella 1982;Vaught et al, 1985) and has also been observed in man (Corli et al, 1984). Baclofen exerts an antinociceptive effect which is not reduced by GABAA (Bartolini et al, 1981;Sawynok & La Bella, 1982), opioid (Levy & Proudfit, 1979;Bartolini et al, 1981) or muscarinic receptor antagonists (Bartolini et al, 1981).…”

Section: Introduction Methodsmentioning

confidence: 99%

CGP 35348, a new GABA_B antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen

Malcangio

Ghelardini

Giotti

et al. 1991

British J Pharmacology

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Section: Introduction Methodsmentioning

confidence: 99%

CGP 35348, a new GABA_B antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen

Malcangio

Ghelardini

Giotti

et al. 1991

British J Pharmacology

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“…It has also been reported that the analgesic effects of muscimol and THIP are not antagonized by bicuculline (18,19). Thus, the in vivo antagonism by bicuculline and picrotoxin of some effects of GABA-mimetics may be difficult to observe without inducing convulsions, as suggested by Murray et al (19).…”

Section: Discussionmentioning

confidence: 95%

Effects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain

Nishibori

Oishi

Itoh

et al. 1986

Japanese Journal of Pharmacology

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Abstract-The effect of GABA-mimetics on histaminergic activity in the mouse brain was investigated.Systemic administration of muscimol (2 and 5 mg/kg), THIP (5-15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5-15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of to/e-methylhistamine (t-MH).There was no regional difference in the inhibitory effect of muscimol on the t-MH accumulation by pargyline treatment. Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by a fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. These results suggest that these GABA-mimetics reduce the HA turnover in the mouse brain.

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“…This result suggests that motor impairment may have impaired the vigorous scratching response or tail flick response to touch stimuli, thereby mimicking analgesia. Several lines of evidence have demonstrated that the stimulation of GABA A receptors by systemic or intracerebroventricular muscimol produces antinociception [19,20] . Although no direct comparison is possible, central GABA receptors have been demonstrated to participate in the production of antinociception, induced by the stimulation of descending pain inhibition systems.…”

Section: Acta Pharmacologica Sinica Npgmentioning

confidence: 99%

Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice

Lim

2010

Acta Pharmacol Sin

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Aim: To investigate the effects of GABA and glycine on analgesia in the central nervous system. Methods: Glycine, taurine, or muscimol was injected with bicuculline into the cistern magna or the lumbar subarachnoidal space in ICR mice. The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed. Results: The dosages of the amino acids administered with bicuculline had no effect on motor behavior in conscious mice. Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicucullineinduced allodynia. Glycine, taurine, and muscimol all antagonized the effects induced by bicuculline in the hot-plate test, regardless of the administration site. Conclusion: Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.

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Analgesic properties of the GABA-minetic thip

Cited by 130 publications

References 6 publications

CGP 35348, a new GABA_B antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen

CGP 35348, a new GABA_B antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen

Effects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain

Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice

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Analgesic properties of the GABA-minetic thip

Cited by 130 publications

References 6 publications

CGP 35348, a new GABAB antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen

CGP 35348, a new GABAB antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen

Effects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain

Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice

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Product

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CGP 35348, a new GABA_B antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen

CGP 35348, a new GABA_B antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen