Analgesic Treatment Approach for Postherpetic Neuralgia: A Narrative Review

Valero, Edmundo Gónima; Mendoza, Walter Antanas Sosa; Sarmiento, Diana A.; Amaya, Sebastian

doi:10.1080/15360288.2023.2174632

Cited by 5 publications

(8 citation statements)

References 50 publications

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“… 12 The existence of multiple methods implies that the efficacy of analgesic therapy is limited. 12 , 35 The current analgesic strategy for PHN often falls short, with less than half of patients achieving adequate 50% pain relief. 13 …”

Section: Discussionmentioning

confidence: 99%

“… 10 This highlights the need for improved treatment methods, 6 as HZ and PHN continue to be prevalent. 11 HZ and ZAP are VZV-infectious peripheral neuropathies or VZV-induced nerve injuries, 12 that require attention from neurologists and researchers as an area of unmet clinical need and as an archetype of neuropathic pain. 13 This study aimed to assess the frequency of HZ, ZAP, and PHN patients visiting neurologists rather than other specialists.…”

Section: Introductionmentioning

confidence: 99%

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Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Xú¹,

Xu²,

Gong³

et al. 2023

JMDH

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Background Herpes zoster (HZ) is a skin disease that can also cause virus-infectious peripheral neuropathies. Despite this, there is limited information on patient preferences for seeking medical attention for HZ and zoster-associated pain (ZAP). Our study aimed to evaluate how frequently patients with ZAP choose to visit neurologists for their symptoms. Methods This study conducted a retrospective review of electronic health records in three general hospitals from January 2017 to June 2022. Using association rule mining, the study analyzed referral behaviors. Results We identified 33,633 patients with 111,488 outpatient visits over 5.5 years. The study found that the majority of patients (74.77–91.22%) visited dermatologists during their first outpatient visit, while only a small percentage (0.86–1.47%) preferred to consult a neurologist. The proportion of patients referred to a specialist during their medical visit varied significantly between different specialties within the same hospital (p <0.05) and even within the same specialty (p<0.05). There was a weak association (Lift:1.00–1.17) of referral behaviors between dermatology and neurology. Across the three hospitals, the average number of visits to a neurologist for ZAP was 1.42–2.49, with an average electronic health record duration of 11–15 days per patient. After consulting with a neurologist, some patients were referred to other specialists. Conclusion It was observed that patients with HZ and ZAP tended to visit a variety of specialists, with only a small number seeking the assistance of neurologists. However, from the perspective of neuroprotection, it is the duty of neurologists to provide more means.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Xú¹,

Xu²,

Gong³

et al. 2023

JMDH

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“…As such, further comprehensive investigation is warranted. [58] Figures 10 and 11 showed that "#0 herpes zoster" was the largest cluster term which encompassed studies on pain and analgesics. "#1 diabetic neuropathy" was the second most common cluster term.…”

Section: Research Hotspots and Trendsmentioning

confidence: 99%

A bibliometric and visualization analysis of global research on postherpetic neuralgia from 2000 to 2022: A review

He,

Miao

et al. 2023

Medicine

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Postherpetic neuralgia (PHN) represents a notable clinical challenge as it is the most prevalent and severe complication of herpes zoster (HZ). The primary objective was to investigate the current research status and hotspots of PHN research during the period from 2000 to 2022. The literature pertaining to PHN was gathered through the utilization of the Web of Science Core Collection, spanning from January 2000 to December 2022. The software, CiteSpace version 6.2.R2, was employed to produce visual depictions of publications related to PHN across various dimensions such as year, country/region, institution, journal, author, keyword, and reference. This study involved a total of 3505 papers. The USA held a dominant position in the production of scholarly articles. Argentina exhibited the highest frequency of participation in international collaboration. Out of all the institutions, Pfizer exhibited the highest degree of productivity. Harvard University exhibited the highest frequency of participation in international collaboration. The Pain exhibited the most noteworthy productivity rate and citation count among all other journals. Ralf Baron was identified as the most productive author, whereas DWORKIN RH attained the highest citation count. Contemporary scholarly investigations are predominantly centered on identifying risk factors, devising preventative measures, and exploring novel and secure methods of pain management. The current investigation has revealed the focal areas and patterns of studies pertaining to PHN. Presently, the research in this field is focused on identifying the risk factors and preventive measures for PHN, alongside exploring novel and secure pain management strategies.

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“…Postherpetic neuralgia is a persistent neuropathic pain induced by the reactivation of the varicella zoster virus [ 1 ]. The lifetime risk of herpes zoster is approximately 30% [ 2 ], and the incidence rate of postherpetic neuralgia after herpes zoster ranges from 5 to 30%, depending on patient age [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The current options for treating postherpetic neuralgia include tricyclic antidepressants (TCAs), antiepileptic drugs, opioids, tramadol, lidocaine, and capsaicin patches [ 1 ]. However, patients must take these medications for a long time, thus increasing the risk of adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Alleviating effect of lavender (Lavandula angustifolia) and its major components on postherpetic pain: a randomized blinded controlled trial

You,

Shin,

Seol

2024

BMC Complement Med Ther

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Background Postherpetic neuralgia (PHN) causes severe pain which can lead to decreased quality-of-life. This study aimed to evaluate the effects of inhalation of lavender (Lavandula angustifolia) oil and its major components (linalool and linalyl acetate) on the pain in patients with PHN. Methods This study was performed at an outpatient clinic. Sixty-four patients with postherpetic neuralgia were randomly allocated to a control group (almond oil) or one of three experimental groups (lavender oil, linalool, or linalyl acetate diluted in almond oil at concentration of 1% v/v), and the participants inhaled the aroma by natural breathing. Quality, severity, and intensity of pain were measured before and after the intervention. Results Six patients discontinued the intervention for personal reasons; hence, data from 58 patients were analyzed (control group, n = 14; 1% lavender oil group, n = 15; 1% linalool, n = 15; 1% linalyl acetate, n = 14). Reduction in sensory pain was greater in the 1% lavender oil group, 1% linalool group, and 1% linalyl acetate group than in the control group (all P < 0.001). Reduction in affective pain was greater in the 1% lavender group (P < 0.001) and the 1% linalool group (P = 0.007) than in the control group. Decreases in pain severity and intensity were significantly greater in all three intervention groups than in the control group. Conclusions Inhalation of lavender oil and its major volatile components effectively reduced the quality, severity, and intensity of postherpetic pain, suggesting that lavender oil, linalool, and linalyl acetate may each be an effective intervention for reducing pain in patients with postherpetic neuralgia. Trial registration This study was retrospectively registered on the Clinical Research Information Service. Registration number: KCT0007772, first registration 06/10/2022.

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Analgesic Treatment Approach for Postherpetic Neuralgia: A Narrative Review

Cited by 5 publications

References 50 publications

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

A bibliometric and visualization analysis of global research on postherpetic neuralgia from 2000 to 2022: A review

Alleviating effect of lavender (Lavandula angustifolia) and its major components on postherpetic pain: a randomized blinded controlled trial

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