Analgesics for the management of acute dental pain in the pediatric population

Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children

“…We collected information on the sum of pain relief scores at each observational time point (for example, 1 hour, 2 hours, 3 hours … 6 hours), which is the total pain relief, and the summed pain intensity difference expressed as the sum of pain intensity differences between each observational time point (for example, 1 hour, 2 hours, 3 hours … 6 hours) and baseline. 6 Once the panel defined patients’ features, clinical conditions, interventions under comparison, and outcomes of interest, we implemented a first electronic survey via Qualtrics to gather feedback from identified stakeholder organizations ( eBox , available online at the end of this article). We asked stakeholders to evaluate the completeness and relevance of each clinical question addressed in the guideline.…”

“…A complete report of the systematic review informing this guideline is available elsewhere. 6 Briefly, we searched MEDLINE via PubMed, Embase, Cochrane Central Register of Controlled Trials, Epistemonikos database, and the gray literature from database inception through September 2021 and conducted study selection, data extraction, and risk of bias assessment (using the Cochrane Risk of Bias 2.0 tool for randomized controlled trials [RCTs] 13 ) independently and in duplicate. We created GRADE summary-of-findings tables to display the effect of the interventions in relative and absolute estimates, number of studies and participants, and certainty of the evidence per outcome.…”

“…However, the risk of harm from opioids is of concern. 6 In a study of children without severe conditions enrolled in Tennessee Medicaid, the incidence of opioid-related serious adverse effects (emergency department visit, hospital admission, death related to an opioid-related adverse effect) for children aged 2 through 5 years was 1.4 of 100,000 days, and for children aged 6 through 11 years, it was 1.3 of 100,000 days. 7 In addition, in children aged 2 through 5 years, opioid-related serious adverse effects were associated with the therapeutic use of the medication 80% of the time, and in children aged 6 through 11 years, the rate was 94% of the time.…”