Analgésie péridurale obstétricale chez une parturiente atteinte d’un déficit en facteur XI : défi inconsidéré ou risque raisonné ?

Schaal, J.-V.; Jarrassier, A.; Renner, Julie; Salvadori, Alessandra; Pelletier, C; Villevieille, T.

doi:10.1016/j.annfar.2013.04.001

Cited by 1 publication

(2 citation statements)

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“…Plasma-derived FXI concentrate, solvent-detergent-treated FFP, and aFVII are alternatives, but due to their high cost, they may not be accessible in some countries. 6 , 12 In our case, the patient had an FXI level of 5, and due to the unavailability of other products, it was decided to use FFP in combination with TXA for prophylaxis, after consultation and discussion with the patient.…”

Section: Discussionmentioning

confidence: 92%

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Management of severe factor XI deficiency in pregnancy: A case report

El Hassouni,

Bentaleb,

Lahbabi

et al. 2024

SAGE Open Medical Case Reports

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Factor XI (FXI) deficiency is one of the rarest coagulation disorders with a frequency of 1:1,000,000. A 30-year-old woman, diagnosed with FXI deficiency at the age of 4, was admitted to our maternity service at 25 weeks of gestation. The patient had no history of hemorrhage or abnormal bleeding, and the clinical examination was unremarkable. Antenatal care was also normal. The parturient was admitted in early labor at 38 weeks of gestation. Despite the absence of clinical hemorrhagic syndrome, a transfusion of fresh frozen plasma combined with tranexamic acid was initiated once the active stage of labor was started. Management of FXI deficiency in pregnant women is a challenge due to its unpredictable bleeding tendency, and careful planning and knowledge of appropriate hemostatic management is pivotal for their care.

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Section: Discussionmentioning

confidence: 92%

“… 6 In the opinion of English authors, epidural anesthesia should be avoided in the presence of bleeding symptoms or severe deficiency but is not absolutely contraindicated. 12 …”

Section: Discussionmentioning

confidence: 99%