Analgetic Activity of Papaya (Carica papaya L.) Leaves Extract

Hasimun, Patonah; Suwendar,; Ernasari, G.I.

doi:10.1016/j.proche.2014.12.019

Cited by 20 publications

(14 citation statements)

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“…Moreover, it contains the papain enzyme, carpain alkaloids, pseudocarpain, carposide, saponins, glicoside, sucrose, and levulose (Wabo et al, 2010). Papaya has been used empirically as meals or as a treatment for urinary tract disturbance, kidney stones, stomachache, hypertension, analgesia, diarrhea, and dysentery (Hasimun et al, 2014).…”

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confidence: 99%

Effect of Aqueous and Ethanolic Extracts of Papaya Seeds on Duodenal Mucosa of Rats

Alalwani¹

2019

IJZI

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Papaya and its seeds are considered important as traditional treatments in Saudi Arabia. This study investigated the effects of aqueous and ethanolic extracts of papaya seeds and their effectiveness on the duodenal mucosa tissues of rats. Twenty-four male rats (Rattus norvegicus) were randomly divided into three numerically equal groups (A,B, and C). Group A, the control group, received daily an oral dose of distilled water. Groups B and C were treated with different extracts (aqueous and ethanolic) of papaya seeds with a daily oral dose of 1 ml/kg bw for 4 weeks. Groups B and C received aqueous extract and ethanolic extract of papaya seeds, respectively. The results showed different histological changes in the duodenal mucosa of treated animals depending on the extract administered. Group B showed enormous number of microvilli which increased the surface area, mucin filled glycocalyx of enterocytes and goblet cells, Golgi apparatus adjacent to the mucin granules with plentiful rough endoplasmic reticulum, and mitochondria which were particularly abundant within enterocytes. Group C showed no difference in the shape, size and number of the microvilli, some of the microvilli appeared to be swollen and joint together. In the goblet cells opening into the lumen, there were only a few electron-dense mucous granules. The cytoplasm was found containing dilated rough endoplasmic reticulum cisternae and lymphocytes were found in the intercellular clefts between enterocytes.

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confidence: 99%

Effect of Aqueous and Ethanolic Extracts of Papaya Seeds on Duodenal Mucosa of Rats

Alalwani¹

2019

IJZI

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“…In addition to the fruit used by the community as food, almost all parts of papaya plants can be used as a natural remedy. Many reports have also shown that the leaves of C. papaya have activity as an anticancer [2], antimicrobial [3][4][5][6], anti-inflammatory [7], analgetic activity [8], antiplasmodial or antimalarial activity [9][10][11], and antioxidant [12][13][14]. Papaya leaves water extract is proved as dengue fever drug [15,16].…”

Section: Introductionmentioning

confidence: 99%

Isolation, Identification, and Antioxidant Activity of Chemical Compound in Ethanol Extract of Papaya Leaves (Carica Papaya L.)

Farid

Iswahyun

2018

Asian J Pharm Clin Res

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Objective: The purpose of this research was to isolate and identify the active antioxidant compound in ethanol extract of papaya leaves (Carica papaya L.).Methods: The methods used were fractionation using vacuum liquid chromatography (VLC), and the active fraction was purified using column chromatography (CC). The pure isolate was obtained with preparative thin-layer chromatographic (TLC) identified by spectroscopy. Its antioxidant activity was evaluated using 2,2-diphenyl-picryl-hydrazyl. The presence of phenols was analyzed using ultraviolet (UV)-visible, Fourier-transform infrared (FTIR), and gas chromatography (GC)–mass spectrometry (MS).Results: The results showed that ethanol extract of papaya leaf has a strong antioxidant activity with IC50 value of 100.0±0.07 ppm. The result of VLC fractionation using mobile phase of chloroform-methanol indicated that the active fraction was EtOH.3 that has antioxidant activity with IC50 of 121.6±0.66 ppm. The purification using CC produced active fraction EtOH.3.3 with IC50 value of 176.4±0.76 ppm. After identified, the active isolate compound EtOH.3.3.1 from preparative TLC, the results of UV-visible spectrophotometry, FTIR spectrophotometry, and GC–MS show the presence of the phenol compounds.Conclusion: The ethanol extract has antioxidant activity and the extract was suspected to contain 2-methoxy-4-vinylphenol compound.

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“…Many scientific investigations have been conducted to evaluate the biological activities of various parts of Carica papaya including their fruits, shoots, leaves, rinds, seeds, roots, or latex. The plant possessed significant biological activities such as antioxidant [ 11 ], immunomodulatory [ 12 ], anti-inflammatory [ 13 ], analgesic [ 14 ], antitumor [ 15 ], wound healing [ 16 ], and antimicrobial [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice

Zeleke

Kebebe

Mulisa

et al. 2017

Journal of Parasitology Research

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Background Currently, antimalarial drug resistance poses a serious challenge. This stresses the need for newer antimalarial compounds. Carica papaya is used traditionally and showed in vitro antimalarial activity. This study attempted to evaluate in vivo antimalarial activity of C. papaya in mice. Methods In vivo antimalarial activity of solvent fractions of the plant was carried out against early P. berghei infection in mice. Parasitemia, temperature, PCV, and body weight of mice were recorded. Windows SPSS version 16 (one-way ANOVA followed by Tukey's post hoc test) was used for data analysis. Results The pet ether and chloroform fractions of C. papaya fruit rind and root produced a significant (p < 0.001) chemosuppressive effect. A maximum parasite suppression of 61.78% was produced by pet ether fraction of C. papaya fruit rind in the highest dose (400 mg/kg/day). Only 400 mg/kg/day dose of chloroform fraction of C. papaya root exhibited a parasite suppression effect (48.11%). But, methanol fraction of the plant parts produced less chemosuppressive effect. Conclusion Pet ether fraction of C. papaya fruit rind had the highest antimalarial activity and could be a potential source of lead compound. Further study should be done to show the chemical and metabolomic profile of active ingredients.

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Analgetic Activity of Papaya (Carica papaya L.) Leaves Extract

Cited by 20 publications

References 1 publication

Effect of Aqueous and Ethanolic Extracts of Papaya Seeds on Duodenal Mucosa of Rats

Effect of Aqueous and Ethanolic Extracts of Papaya Seeds on Duodenal Mucosa of Rats

Isolation, Identification, and Antioxidant Activity of Chemical Compound in Ethanol Extract of Papaya Leaves (Carica Papaya L.)

In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice

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